(Q40003065)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18337418%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

title

Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons (English)

1 reference

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4 January 2020

2

1 reference

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4 January 2020

Mikael Simons

8

1 reference

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4 January 2020

7

Stefan W Hell

1 reference

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4 January 2020

author name string

Anja Schneider

1

1 reference

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4 January 2020

Masanori Honsho

3

1 reference

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4 January 2020

Matthias Gralle

4

1 reference

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4 January 2020

Gerald Donnert

5

1 reference

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4 January 2020

Fred Wouters

6

1 reference

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4 January 2020

language of work or name

English

0 references

publication date

1 March 2008

1 reference

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4 January 2020

published in

Journal of Neuroscience

1 reference

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4 January 2020

volume

28

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4 January 2020

issue

11

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4 January 2020

page(s)

2874-2882

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describes a project that uses

4 January 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6670660/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

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12 December 2020

The role of cholesterol in the biosynthesis of beta-amyloid

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12 December 2020

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

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12 December 2020

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

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12 December 2020

Lipid rafts act as specialized domains for tetanus toxin binding and internalization into neurons

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12 December 2020

Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2

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12 December 2020

Curvature of clathrin-coated pits driven by epsin

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12 December 2020

Flotillin-1/reggie-2 traffics to surface raft domains via a novel golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation

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12 December 2020

The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing

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12 December 2020

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

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12 December 2020

Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

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12 December 2020

Alzheimer's disease: the cholesterol connection

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12 December 2020

Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells

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12 December 2020

The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein

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12 December 2020

App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

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12 December 2020

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

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12 December 2020

Accumulation of flotillin‐1 in tangle‐bearing neurones of Alzheimer's disease

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12 December 2020

Immunofluorescence stimulated emission depletion microscopy

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12 December 2020

Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression

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12 December 2020

BACE1 Suppression by RNA Interference in Primary Cortical Neurons

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12 December 2020

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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12 December 2020

Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?

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12 December 2020

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

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12 December 2020

Visualization of molecular activities inside living cells with fluorescent labels

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12 December 2020

Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice

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12 December 2020

Neuronal membrane cholesterol loss enhances amyloid peptide generation

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12 December 2020

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

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12 December 2020

LRP and Alzheimer's disease

1 reference

12 December 2020

Scaffolding microdomains and beyond: the function of reggie/flotillin proteins

1 reference

12 December 2020

Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

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12 December 2020

Fluorescence lifetime heterogeneity resolution in the frequency domain by lifetime moments analysis

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12 December 2020

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

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12 December 2020

Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells

1 reference

12 December 2020

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target

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12 December 2020

Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis

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12 December 2020

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

1 reference

12 December 2020

Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments

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12 December 2020

The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein

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12 December 2020

Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites

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12 December 2020

STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis

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12 December 2020

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

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12 December 2020

Macromolecular-scale resolution in biological fluorescence microscopy

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12 December 2020

Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1.

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12 December 2020

Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis

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12 December 2020

Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin

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12 December 2020

Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains

1 reference

12 December 2020

Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton

1 reference

12 December 2020

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

1 reference

12 December 2020

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

12 December 2020

Degradation of nicastrin involves both proteasome and lysosome

1 reference

12 December 2020

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

1 reference

12 December 2020

Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway.

1 reference

12 December 2020

Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding

1 reference

12 December 2020

Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis

1 reference

12 December 2020

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

1 reference

12 December 2020

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

1 reference

12 December 2020

1 reference

12 December 2020

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

12 December 2020

Enhanced release of amyloid beta-protein from codon 670/671 "Swedish" mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways

1 reference

12 December 2020

Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody

1 reference

12 December 2020

Identification of caveolin and caveolin-related proteins in the brain.

1 reference

12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

12 December 2020

Identification of reggie-1 and reggie-2 as plasmamembrane-associated proteins which cocluster with activated GPI-anchored cell adhesion molecules in non-caveolar micropatches in neurons

1 reference

12 December 2020

10.1523/JNEUROSCI.5345-07.2008

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18337418%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

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4 January 2020

1 reference