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Alzheimer's disease: the cholesterol connection
scientific article (publication date: April 2003)
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Europe PubMed Central
title
Alzheimer's disease: the cholesterol connection
(English)
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main subject
Alzheimer's disease
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based on heuristic
inferred from title
author
Rudolph E. Tanzi
series ordinal
2
object named as
Rudolph E Tanzi
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author name string
Luigi Puglielli
series ordinal
1
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Dora M Kovacs
series ordinal
3
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language of work or name
English
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publication date
April 2003
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published in
Nature Neuroscience
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volume
6
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issue
4
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page(s)
345-51
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cites work
New frontiers in Alzheimer's disease genetics
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
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inferred from DOI database lookup
The role of presenilins in Alzheimer's disease
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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inferred from DOI database lookup
Results of a high-resolution genome screen of 437 Alzheimer's disease families
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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Translating cell biology into therapeutic advances in Alzheimer's disease
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Crossref
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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inferred from DOI database lookup
Alzheimer's disease: genetic studies and transgenic models
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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inferred from DOI database lookup
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
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reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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inferred from DOI database lookup
Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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A protective role of the low density lipoprotein receptor-related protein against amyloid beta-protein toxicity
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Crossref
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells.
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Crossref
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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inferred from DOI database lookup
Apolipoprotein E receptors: linking brain development and Alzheimer's disease
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Crossref
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease
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Crossref
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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inferred from DOI database lookup
Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
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Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The use of measured genotype information in the analysis of quantitative phenotypes in man. II. The role of the apolipoprotein E polymorphism in determining levels, variability, and covariability of cholesterol, betalipoprotein, and triglycerides in
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of apolipoprotein E genotype on blood lipid composition and membrane platelet fluidity in Alzheimer’s disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Plasma lipids and cholesterol esterification in Alzheimer's disease.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study
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Crossref
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Statins and the risk of dementia
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Crossref
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of neurodegenerative disorders: Part 1: protein aggregates.
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Crossref
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
based on heuristic
inferred from DOI database lookup
Serum lipoprotein levels, statin use, and cognitive function in older women
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
based on heuristic
inferred from DOI database lookup
Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
based on heuristic
inferred from DOI database lookup
Fluvastatin: effects beyond cholesterol lowering
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FNN0403-345
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7 January 2021
based on heuristic
inferred from DOI database lookup
Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Alzheimer amyloid precursor is associated with the detergent- insoluble cytoskeleton
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A detergent-insoluble membrane compartment contains A beta in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The interaction between Alzheimer amyloid beta(1-40) peptide and ganglioside GM1-containing membranes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid beta-protein (A beta) associated with lipid molecules: immunoreactivity distinct from that of soluble A beta.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of cholesterol in the biosynthesis of beta-amyloid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cholesterol metabolism in the brain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Is there a connection between the concentration of cholesterol circulating in plasma and the rate of neuritic plaque formation in Alzheimer disease?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The metabolism of cholestanol, cholesterol, and bile acids in cerebrotendinous xanthomatosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased concentrations of cholestanol and apolipoprotein B in the cerebrospinal fluid of patients with cerebrotendinous xanthomatosis. Effect of chenodeoxycholic acid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNN0403-345
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/NN0403-345
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1128796
OpenCitations bibliographic resource ID
1128796
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1128796
PubMed publication ID
12658281
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1128796
ResearchGate publication ID
10837724
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