(Q35110927)

English

Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 August 2017

Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

author name string

Kulandaivelu S Vetrivel

1

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Arghya Barman

2

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Ying Chen

3

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Phuong D Nguyen

4

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Steven L Wagner

5

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Rajeev Prabhakar

6

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Gopal Thinakaran

7

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

language of work or name

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publication date

3 June 2011

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Europe PubMed Central

PubMed publication ID

6 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

6 August 2017

286

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

29

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

26166-26177

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3138254/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Amyloid precursor protein trafficking, processing, and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Biosynthesis, remodelling and functions of mammalian GPI-anchored proteins: recent progress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

The Alzheimer's disease beta-secretase enzyme, BACE1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

BACE1 regulates voltage-gated sodium channels and neuronal activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Functional plasticity in the substrate binding site of beta-secretase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

The gamma-secretase complex: machinery for intramembrane proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

ELISA analysis of beta-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Maturation and pro-peptide cleavage of beta-secretase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Applications of retrovirus-mediated expression cloning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Beta-amyloid precursor protein cleavage by a membrane-bound protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

9 July 2018

Processing of beta-secretase by furin and other members of the proprotein convertase family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.260471

21 January 2018

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.260471

21 January 2018

Computational modeling of substrate specificity and catalysis of the β-secretase (BACE1) enzyme.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.260471

21 January 2018

Flap position of free memapsin 2 (beta-secretase), a model for flap opening in aspartic protease catalysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.260471

21 January 2018

Apo and inhibitor complex structures of BACE (beta-secretase).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.260471

21 January 2018

The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.260471

21 January 2018

Employing a superior BACE1 cleavage sequence to probe cellular APP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.260471

21 January 2018

Conformational flexibility of beta-secretase: molecular dynamics simulation and essential dynamics analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

27 September 2018

Generation and regulation of beta-amyloid peptide variants by neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3138254

27 September 2018

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21642424

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/21642424

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.260471

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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