(Q40539017)

21 September 2017

Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1. (English)

1 reference

21 September 2017

Isam Qahwash

1

1 reference

21 September 2017

Wanxia He

2

1 reference

21 September 2017

Alfredo Tomasselli

3

1 reference

21 September 2017

Rolf F Kletzien

4

1 reference

21 September 2017

Riqiang Yan

5

1 reference

21 September 2017

language of work or name

English

0 references

publication date

2 July 2004

1 reference

Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

37

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21 September 2017

39010-39016

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Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Processing of beta-secretase by furin and other members of the proprotein convertase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Employing a superior BACE1 cleavage sequence to probe cellular APP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Solution structures of micelle-bound amyloid beta-(1-40) and beta-(1-42) peptides of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Structural and kinetic features of amyloid beta-protein fibrillogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Comparison of the aggregation properties, secondary structure and apoptotic effects of wild-type, Flemish and Dutch N-terminally truncated amyloid beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

beta-Amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe/PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407101200

21 January 2018

Identifiers

DOI

10.1074/JBC.M407101200

1 reference

21 September 2017

1 reference