(Q38114865)

29 August 2017

title

OCTN cation transporters in health and disease: role as drug targets and assay development (English)

1 reference

29 August 2017

Lorena Pochini

1

1 reference

29 August 2017

Mariafrancesca Scalise

series ordinal

2

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29 August 2017

Michele Galluccio

series ordinal

3

1 reference

29 August 2017

Cesare Indiveri

series ordinal

4

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29 August 2017

publication date

14 June 2013

1 reference

Journal of Biomolecular Screening

29 August 2017

published in

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29 August 2017

volume

18

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29 August 2017

issue

8

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29 August 2017

page(s)

851-867

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New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process

29 August 2017

cites work

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Role of transporters in drug interactions

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Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy

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Drug transporters in drug efficacy and toxicity

21 January 2018

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Interaction of innovative small molecule drugs used for cancer therapy with drug transporters

21 January 2018

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pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions.

21 January 2018

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The SLC22 family with transporters of organic cations, anions and zwitterions

21 January 2018

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Role of organic cation transporters in drug-induced toxicity

21 January 2018

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Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters

21 January 2018

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The Transporter Classification Database: recent advances

21 January 2018

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Strategies of bacterial over expression of membrane transporters relevant in human health: the successful case of the three members of OCTN subfamily

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057113493006

Reconstitution into liposomes and functional characterization of the carnitine transporter from renal cell plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Over-expression in Escherichia coli, purification and reconstitution in liposomes of the third member of the OCTN sub-family: the mouse carnitine transporter OCTN3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Three-dimensional structures of membrane proteins from genomic sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

The structural basis of secondary active transport mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Structural basis of Na(+)-independent and cooperative substrate/product antiport in CaiT

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Crystal structure of the carnitine transporter and insights into the antiport mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Inactivation by omeprazole of the carnitine transporter (OCTN2) reconstituted in liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Molecular and functional characterization of organic cation/carnitine transporter family in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Molecular and cellular physiology of renal organic cation and anion transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Expression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Discovery of the ergothioneine transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Regulation by physiological cations of acetylcholine transport mediated by human OCTN1 (SLC22A4). Implications in the non-neuronal cholinergic system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Functional variants of OCTN cation transporter genes are associated with Crohn disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Carnitine deficiency in OCTN2-/- newborn mice leads to a severe gut and immune phenotype with widespread atrophy, apoptosis and a pro-inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Carnitine in metabolic disease: potential for pharmacological intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Mechanisms for insulin resistance: common threads and missing links

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Drug penetration in solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Metabolic agents that enhance ATP can improve cognitive functioning: a review of the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Acylcarnitines: role in brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Serum carnitine levels and levocarnitine supplementation in institutionalized Huntington's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Characterization of organic cation/carnitine transporter family in human sperm

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Expression and distribution of OCTN2 in mouse epididymis and its association with obstructive azoospermia in juvenile visceral steatosis mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Studies on functional sites of organic cation/carnitine transporter OCTN2 (SLC22A5) using a Ser467Cys mutant protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Human OCTN2 (SLC22A5) is down-regulated in virus- and nonvirus-mediated cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Systemic primary carnitine deficiency: an overview of clinical manifestations, diagnosis, and management

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Genotype-phenotype correlation in primary carnitine deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Cytoprotective effect of acetyl-L-carnitine evidenced by analysis of gene expression in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Impaired skin fibroblast carnitine uptake in primary systemic carnitine deficiency manifested by childhood carnitine-responsive cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Quantitative structure activity relationship for inhibition of human organic cation/carnitine transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

High affinity carnitine transporters from OCTN family in neural cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Upregulation of mammary gland OCTNs maintains carnitine homeostasis in suckling infants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

OCTN3: A Na+-independent L-carnitine transporter in enterocytes basolateral membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

The epithelial cholinergic system of the airways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Organic cation/carnitine transporter family expression patterns in adult murine heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Role of estrogen in renal handling of organic cation, tetraethylammonium: in vivo and in vitro studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Regulatory role of testosterone in organic cation transport: in vivo and in vitro studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

L-Carnitine transport in mouse renal and intestinal brush-border and basolateral membrane vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Distinct transport activity of tetraethylammonium from L-carnitine in rat renal brush-border membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Carnitine/organic cation transporter OCTN2 (Slc22a5) is responsible for renal secretion of cephaloridine in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Regulation of Octn2 transporter (SLC22A5) by peroxisome proliferator activated receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Cytokine regulation of OCTN2 expression and activity in small and large intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

SLC22A5/OCTN2 expression in breast cancer is induced by estrogen via a novel intronic estrogen-response element (ERE).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5)

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Expression patterns of the organic cation/carnitine transporter family in adult murine brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

OCTN3 is a mammalian peroxisomal membrane carnitine transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Carnitine: transport and physiological functions in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Decreased mitochondrial carnitine translocase in skeletal muscles impairs utilization of fatty acids in insulin-resistant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Impact on carnitine homeostasis of short-term treatment with the pivalate prodrug cefditoren pivoxil

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Biosynthesis of flavin cofactors in man: implications in health and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Brief report: a deficiency of carnitine-acylcarnitine translocase in the inner mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Carnitine-acylcarnitine translocase deficiency with severe hypoglycemia and auriculo ventricular block. Translocase assay in permeabilized fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Inflammatory bowel disease: cause and immunobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Host-gut microbiota metabolic interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Interactions between the microbiota and the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Reciprocal interactions of the intestinal microbiota and immune system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Rheumatic manifestations of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Carnitine biosynthesis in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Regional brain changes in aging healthy adults: general trends, individual differences and modifiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

A review of antioxidants and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Neuroprotective activity of acetyl-L-carnitine: studies in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Carnitine/organic cation transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Inactivation by Hg2+ and methylmercury of the glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: Prediction of the involvement of a CXXC motif by homology modelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Inhibition of the OCTN2 carnitine transporter by HgCl2 and methylmercury in the proteoliposome experimental model: insights in the mechanism of toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Employing Escherichia coli to functionally express, purify, and characterize a human transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Cell free expression and functional reconstitution of eukaryotic drug transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Regulation of human EGF receptor by lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Studies on intestinal absorption of sulpiride (2): transepithelial transport of sulpiride across the human intestinal cell line Caco-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Interaction of imatinib with human organic ion carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Beneficial effects of L-carnitine in myoblastic C2C12 cells. Interaction with zidovudine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Inhibition of OCTN2-mediated transport of carnitine by etoposide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Synthesis and characterization of carnitine nitro-derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Adaptation of plasma membrane amino acid transport mechanisms to physiological demands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Novel renal amino acid transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

The transport of glutamine into mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

Amino acid transport across mammalian intestinal and renal epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113493006

21 January 2018

Identifiers

DOI

10.1177/1087057113493006

1 reference

29 August 2017

1 reference