(Q38115124)

29 August 2017

title

Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism (English)

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29 August 2017

Makoto Kuro-o

1

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29 August 2017

language of work or name

English

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publication date

18 June 2013

1 reference

Nature Reviews Nephrology

29 August 2017

published in

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29 August 2017

volume

9

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29 August 2017

issue

11

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29 August 2017

page(s)

650-660

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https://scigraph.springernature.com/pub.10.1038/nrneph.2013.111

29 August 2017

exact match

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FGF23 induces left ventricular hypertrophy

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Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system

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Initial FGF23-mediated signaling occurs in the distal convoluted tubule

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Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein.

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BetaKlotho is required for metabolic activity of fibroblast growth factor 21

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Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

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31 March 2020

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31 March 2020

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Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients.

31 March 2020

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Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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p53 mutant mice that display early ageing-associated phenotypes

31 March 2020

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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

31 March 2020

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Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

31 March 2020

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Stress-induced premature senescence in mononuclear cells from patients on long-term hemodialysis

31 March 2020

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31 March 2020

Liver metabolism in CRF.

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Serum fibroblast growth factor-21 concentration is associated with residual renal function and insulin resistance in end-stage renal disease patients receiving long-term peritoneal dialysis.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Increased inorganic phosphate induces human endothelial cell apoptosis in vitro

31 March 2020

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Dietary phosphorus acutely impairs endothelial function

31 March 2020

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Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Phosphate regulation of vascular smooth muscle cell calcification

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Phosphonoformic acid prevents vascular smooth muscle cell calcification by inhibiting calcium-phosphate deposition.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Mineral phases of calcium phosphate

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Spontaneous precipitation of brushite in urine: evidence that brushite is the nidus of renal stones originating as calcium phosphate

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Fetuin-A is a mineral carrier protein: small angle neutron scattering provides new insight on Fetuin-A controlled calcification inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

A shielding topology stabilizes the early stage protein-mineral complexes of fetuin-A and calcium phosphate: a time-resolved small-angle X-ray study.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Structural dynamics of a colloidal protein-mineral complex bestowing on calcium phosphate a high solubility in biological fluids

31 March 2020

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Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles

31 March 2020

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The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Phosphate-dependent stimulation of MGP and OPN expression in osteoblasts via the ERK1/2 pathway is modulated by calcium

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Fetuin-mineral complex reflects extraosseous calcification stress in CKD

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Fully phosphorylated fetuin-A forms a mineral complex in the serum of rats with adenine-induced renal failure

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Effects of phosphate binders in moderate CKD

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Calcium deficiency reduces circulating levels of FGF23.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

RENAL DAMAGE FOLLOWING THE INGESTION OF A DIET CONTAINING AN EXCESS OF INORGANIC PHOSPHATE

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Acute phosphate nephropathy-an emerging threat

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2013.111

Renal toxicity of phosphate in rats

31 March 2020

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A micropuncture study of renal phosphate transport in rats with chronic renal failure and secondary hyperparathyroidism

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Phosphate excess and progressive renal failure: the precipitation-calcification hypothesis

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Calcium phosphate-induced renal epithelial injury and stone formation: involvement of reactive oxygen species

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The kidney and bisphosphonates

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Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo.

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Human nephron number: implications for health and disease

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Long-term consequences of kidney donation

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Effects of aging on glomerular function and number in living kidney donors

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Bone and mineral metabolism and fibroblast growth factor 23 levels after kidney donation

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The distribution of urinary calcium excretions in normal persons and stone-formers

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Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium

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High citrate diet delays progression of renal insufficiency in the ClC-5 knockout mouse model of Dent's disease

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12 December 2020

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12 December 2020

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Genetic syndromes in man with potential relevance to the pathobiology of aging

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12 December 2020

Identifiers

DOI

10.1038/NRNEPH.2013.111

1 reference

Dimensions Publication ID

29 August 2017

1004441144

0 references

1 reference