(Q38116575)

29 August 2017

title

Androgen receptor modulators: a marriage of chemistry and biology (English)

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29 August 2017

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Iain J McEwan

1

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29 August 2017

publication date

1 June 2013

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Future Medicinal Chemistry

29 August 2017

published in

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29 August 2017

volume

5

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29 August 2017

issue

10

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29 August 2017

page(s)

1109-1120

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Androgen actions and the ovary

29 August 2017

cites work

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Androgen receptor functions in male and female physiology

21 January 2018

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Androgens and the male reproductive tract: an overview of classical roles and current perspectives.

21 January 2018

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Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer

21 January 2018

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Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer

21 January 2018

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Intrinsic disorder in the androgen receptor: identification, characterisation and drugability

21 January 2018

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Allosteric modulators of steroid hormone receptors: structural dynamics and gene regulation

21 January 2018

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Conformational analysis of the androgen receptor amino-terminal domain involved in transactivation. Influence of structure-stabilizing solutes and protein-protein interactions

21 January 2018

1 reference

Induced alpha-helix structure in AF1 of the androgen receptor upon binding transcription factor TFIIF.

21 January 2018

1 reference

Structural characterization of the native NH2-terminal transactivation domain of the human androgen receptor: a collapsed disordered conformation underlies structural plasticity and protein-induced folding

21 January 2018

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The NH(2)-terminal and carboxyl-terminal interaction in the human androgen receptor

21 January 2018

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Dependence of selective gene activation on the androgen receptor NH2- and COOH-terminal interaction

21 January 2018

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Compartmentalization of androgen receptor protein-protein interactions in living cells

21 January 2018

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Alternatively spliced androgen receptor variants

21 January 2018

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Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance

21 January 2018

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A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth

21 January 2018

1 reference

Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer

21 January 2018

1 reference

Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

21 January 2018

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Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

21 January 2018

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A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities

21 January 2018

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Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival

21 January 2018

1 reference

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

21 January 2018

1 reference

Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941.

21 January 2018

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Minireview: Alternative activation pathways for the androgen receptor in prostate cancer

21 January 2018

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Recent developments in antiandrogens and selective androgen receptor modulators

21 January 2018

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Outsmarting androgen receptor: creative approaches for targeting aberrant androgen signaling in advanced prostate cancer

21 January 2018

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Targeting the androgen receptor pathway in prostate cancer

21 January 2018

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Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer

21 January 2018

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Molecular mechanisms of castration-resistant prostate cancer progression

21 January 2018

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Improving the management of patients with prostate cancer receiving long-term androgen deprivation therapy

21 January 2018

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Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

21 January 2018

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Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit

21 January 2018

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Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

21 January 2018

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Modulation of Androgen Receptor Activation Function 2 by Testosterone and Dihydrotestosterone

21 January 2018

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Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor

21 January 2018

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Recognition and accommodation at the androgen receptor coactivator binding interface

21 January 2018

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Androgen receptor is targeted to distinct subcellular compartments in response to different therapeutic antiandrogens

21 January 2018

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Antiandrogens prevent stable DNA-binding of the androgen receptor

21 January 2018

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In vivo amplification of the androgen receptor gene and progression of human prostate cancer

21 January 2018

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Mutation of histidine 874 in the androgen receptor ligand-binding domain leads to promiscuous ligand activation and altered p160 coactivator interactions

21 January 2018

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Development of a second-generation antiandrogen for treatment of advanced prostate cancer

21 January 2018

1 reference

ARN-509: a novel antiandrogen for prostate cancer treatment

21 January 2018

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Drug safety is a barrier to the discovery and development of new androgen receptor antagonists.

21 January 2018

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Increased survival with enzalutamide in prostate cancer after chemotherapy

21 January 2018

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Mechanism of antiandrogen action: conformational changes of the receptor.

21 January 2018

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Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics

21 January 2018

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Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug Design

21 January 2018

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Structural basis for antagonism and resistance of bicalutamide in prostate cancer

21 January 2018

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Structural basis for accommodation of nonsteroidal ligands in the androgen receptor

21 January 2018

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Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor

21 January 2018

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The impact of point mutations in the human androgen receptor: classification of mutations on the basis of transcriptional activity

21 January 2018

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Muscle-bound? A tissue-selective nonsteroidal androgen receptor modulator

21 January 2018

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Selective androgen receptor modulators as function promoting therapies

21 January 2018

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Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators

21 January 2018

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Structure of the ligand-binding domain (LBD) of human androgen receptor in complex with a selective modulator LGD2226

21 January 2018

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Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats

21 January 2018

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Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats

21 January 2018

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Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator

21 January 2018

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The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol

21 January 2018

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Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone.

21 January 2018

1 reference

Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs)

21 January 2018

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A surface on the androgen receptor that allosterically regulates coactivator binding

21 January 2018

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Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening.

21 January 2018

1 reference

Alternative inhibition of androgen receptor signaling: peptidomimetic pyrimidines as direct androgen receptor/coactivator disruptors

21 January 2018

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Inhibitors of androgen receptor activation function-2 (AF2) site identified through virtual screening

21 January 2018

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Structural basis of androgen receptor binding to selective androgen response elements.

21 January 2018

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DNA recognition by nuclear receptors

21 January 2018

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Cell- and gene-specific regulation of primary target genes by the androgen receptor

21 January 2018

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Transcriptional profiling of androgen receptor (AR) mutants suggests instructive and permissive roles of AR signaling in germ cell development.

21 January 2018

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New androgen receptor genomic targets show an interaction with the ETS1 transcription factor.

21 January 2018

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A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth

21 January 2018

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Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

21 January 2018

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Cyclic pyrrole-imidazole polyamides targeted to the androgen response element

21 January 2018

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Antitumor activity of a pyrrole-imidazole polyamide

21 January 2018

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Androgen receptor decoy molecules block the growth of prostate cancer

21 January 2018

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Sintokamides A to E, chlorinated peptides from the sponge Dysidea sp. that inhibit transactivation of the N-terminus of the androgen receptor in prostate cancer cells.

21 January 2018

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Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor

21 January 2018

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Chemoprevention of prostate cancer through dietary agents: progress and promise

21 January 2018

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Chemoprevention of prostate cancer: Natural compounds, antiandrogens, and antioxidants - In vivo evidence

21 January 2018

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Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP.

21 January 2018

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Silibinin down-regulates prostate epithelium-derived Ets transcription factor in LNCaP prostate cancer cells

21 January 2018

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Molecular targets and anticancer potential of indole-3-carbinol and its derivatives

21 January 2018

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Antiandrogenic activity of anthranilic acid ester derivatives as novel lead structures to inhibit prostate cancer cell proliferation

21 January 2018

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Lupeol, a novel androgen receptor inhibitor: implications in prostate cancer therapy.

21 January 2018

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Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer

21 January 2018

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The phytoestrogen genistein is a tissue-specific androgen receptor modulator

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/FMC.13.69

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release_r5wlcu2n6ngh3nt5icvvts4yr4

29 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/r5wlcu2n6ngh3nt5icvvts4yr4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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