(Q38119248)

29 August 2017

title

Liver X receptor modulators: a review of recently patented compounds (2009 - 2012). (English)

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29 August 2017

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Jon Loren

1

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29 August 2017

Zhihong Huang

series ordinal

2

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29 August 2017

Bryan A Laffitte

series ordinal

3

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29 August 2017

Valentina Molteni

series ordinal

4

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29 August 2017

language of work or name

English

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publication date

5 July 2013

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Expert Opinion on Therapeutic Patents

29 August 2017

published in

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29 August 2017

volume

23

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29 August 2017

issue

10

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29 August 2017

page(s)

1317-1335

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LXRS and FXR: the yin and yang of cholesterol and fat metabolism

29 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Liver X Receptor Signaling Pathways in Cardiovascular Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Combinatorial control of gene expression by nuclear receptors and coregulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Coregulator codes of transcriptional regulation by nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

A transcriptional co-repressor that interacts with nuclear hormone receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Apolipoprotein E and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Accumulation of foam cells in liver X receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Biochemistry. An absorbing study of cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Role of LXRs in control of lipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Synthetic LXR agonists increase LDL in CETP species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Liver X receptor agonists inhibit tissue factor expression in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

LXR-dependent gene expression is important for macrophage survival and the innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

LXR signaling couples sterol metabolism to proliferation in the acquired immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Inflammatory Reactions in the Pathogenesis of Atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Evaluation of anti-atherosclerotic activities of PPAR-α, PPAR-γ, and LXR agonists in hyperlipidemic atherosclerosis-susceptible F(1)B hamsters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Synthetic LXR agonist inhibits the development of atherosclerosis in New Zealand White rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Dissection of the insulin-sensitizing effect of liver X receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

ApoE promotes the proteolytic degradation of Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Liver X receptor activation restores memory in aged AD mice without reducing amyloid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Liver X receptor β protects dopaminergic neurons in a mouse model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Blazeispirol A from Agaricus blazei fermentation product induces cell death in human hepatoma Hep 3B cells through caspase-dependent and caspase-independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Stereoselective synthesis of (22R)- and (22S)-castasterone/ponasterone A hybrid compounds and evaluation of their molting hormone activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Discovery of tertiary sulfonamides as potent liver X receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

A liver-selective LXR inverse agonist that suppresses hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.814640

10.1517/13543776.2013.814640

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference