(Q30433187)

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Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling

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Europe PubMed Central

PMC publication ID

11 November 2017

Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling (English)

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

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liver X receptor agonist

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Carmella Evans-Molina

11

object named as

Carmella Evans-Molina

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Europe PubMed Central

11 November 2017

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author name string

Takeshi Ogihara

1

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Europe PubMed Central

PMC publication ID

11 November 2017

Jen-Chieh Chuang

2

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Europe PubMed Central

PMC publication ID

11 November 2017

George L Vestermark

3

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Europe PubMed Central

PMC publication ID

11 November 2017

James C Garmey

4

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Europe PubMed Central

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11 November 2017

Robert J Ketchum

5

1 reference

Europe PubMed Central

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11 November 2017

Xiaolun Huang

6

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Kenneth L Brayman

7

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Michael O Thorner

8

1 reference

Europe PubMed Central

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11 November 2017

Joyce J Repa

9

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Europe PubMed Central

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11 November 2017

Raghavendra G Mirmira

10

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11 November 2017

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11 December 2009

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Europe PubMed Central

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11 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

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11 November 2017

285

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Europe PubMed Central

PMC publication ID

11 November 2017

8

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Europe PubMed Central

PMC publication ID

11 November 2017

5392-5404

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2820768/fullTextXML

based on heuristic

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Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Metabolic cycling in control of glucose-stimulated insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Research resource: nuclear hormone receptor expression in the endocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Glycerolipid metabolism and signaling in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Analyzing real-time PCR data by the comparative C(T) method

1 reference

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20 June 2018

Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Classification and predictive modeling of liver X receptor response elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

MAFA controls genes implicated in insulin biosynthesis and secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Comparative analysis of insulin gene promoters: implications for diabetes research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2

1 reference

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20 June 2018

Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Liver X receptors as integrators of metabolic and inflammatory signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

The unique cytoarchitecture of human pancreatic islets has implications for islet cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Metabolic regulation of the pancreatic beta-cell ATP-sensitive K+ channel: a pas de deux

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Quantitative real-time polymerase chain reaction measurement of regulators of G-protein signaling mRNA levels in mouse tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

p38 MAPK is involved in activin A- and hepatocyte growth factor-mediated expression of pro-endocrine gene neurogenin 3 in AR42J-B13 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Regulation of insulin gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Glucose homeostasis in the nonobese diabetic mouse at the prediabetic stage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

Regulation of the C/EBP-related gene gadd153 by glucose deprivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820768

20 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.064659

21 January 2018

The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.064659

21 January 2018

Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.064659

21 January 2018

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.064659

21 January 2018

Dissection of the insulin-sensitizing effect of liver X receptor ligands

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.064659

21 January 2018

Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.064659

21 January 2018

Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.064659

21 January 2018

Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.064659

21 January 2018

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.064659

21 January 2018

Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.064659

21 January 2018

Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.064659

21 January 2018

Glucose-stimulated insulin biosynthesis depends on insulin-stimulated insulin gene transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/20007976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20007976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/20007976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR

1 reference

https://pubmed.ncbi.nlm.nih.gov/20007976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of crystal structures of LXRbeta in relation to plasticity of the ligand-binding domain upon ligand binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/20007976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.064659

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

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