(Q46025705)

18 December 2017

title

The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro. (English)

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18 December 2017

5

O Korsgren

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18 December 2017

H Scholz

1

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18 December 2017

T Lund

2

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18 December 2017

M K Dahle

3

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18 December 2017

J L Collins

4

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18 December 2017

J E Wang

6

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18 December 2017

A Foss

7

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18 December 2017

publication date

5 May 2009

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18 December 2017

published in

Diabetologia

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18 December 2017

volume

52

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18 December 2017

issue

7

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18 December 2017

page(s)

1352-1362

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18 December 2017

https://scigraph.springernature.com/pub.10.1007/s00125-009-1366-z

exact match

0 references

cites work

Isolated human islets trigger an instant blood mediated inflammatory reaction: implications for intraportal islet transplantation as a treatment for patients with type 1 diabetes

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00125-009-1366-Z

Current status of clinical islet transplantation

21 January 2018

1 reference

12 December 2020

Inducible nitric oxide synthase-nitric oxide plays an important role in acute and severe hypoxic injury to pancreatic beta cells

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12 December 2020

The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

1 reference

12 December 2020

Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice

1 reference

12 December 2020

Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats

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12 December 2020

International trial of the Edmonton protocol for islet transplantation.

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12 December 2020

Liver X Receptor Activation Potentiates the Lipopolysaccharide Response in Human Macrophages

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12 December 2020

Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells

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12 December 2020

Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation

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12 December 2020

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE

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12 December 2020

Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells.

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12 December 2020

Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke.

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12 December 2020

Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts

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12 December 2020

Secretory defects induced by immunosuppressive agents on human pancreatic beta-cells

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12 December 2020

The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse

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12 December 2020

Liver X receptor agonists inhibit tissue factor expression in macrophages

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12 December 2020

Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

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12 December 2020

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

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12 December 2020

Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest

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12 December 2020

T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR

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12 December 2020

Toll-like receptor 4 suppression leads to islet allograft survival

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12 December 2020

The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction

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12 December 2020

Elevated vascular endothelial growth factor production in islets improves islet graft vascularization.

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12 December 2020

Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells.

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12 December 2020

Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation

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12 December 2020

Optimising islet engraftment is critical for successful clinical islet transplantation

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12 December 2020

Activation of the liver X receptor protects against hepatic injury in endotoxemia by suppressing Kupffer cell activation

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12 December 2020

Integration of metabolism and inflammation by lipid-activated nuclear receptors

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12 December 2020

Glucocorticoids reduce pro-inflammatory cytokines and tissue factor in vitro and improve function of transplanted human islets in vivo

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12 December 2020

Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines

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12 December 2020

Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells.

1 reference

12 December 2020

Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes

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12 December 2020

Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation

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12 December 2020

Five-year follow-up after clinical islet transplantation

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12 December 2020

Tissue factor and CCL2/monocyte chemoattractant protein-1 released by human islets affect islet engraftment in type 1 diabetic recipients

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12 December 2020

The impact of short-term ciclosporin A treatment on insulin secretion and insulin sensitivity in man

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12 December 2020

The ADP/ATP ratio: A novel predictive assay for quality assessment of isolated pancreatic islets.

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12 December 2020

The innate immune response under the control of the LXR pathway

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12 December 2020

Induction of the chemokine interferon-gamma-inducible protein-10 in human pancreatic islets during enterovirus infection

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12 December 2020

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

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12 December 2020

Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages

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12 December 2020

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells

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12 December 2020

Angiopoietin-1 production in islets improves islet engraftment and protects islets from cytokine-induced apoptosis

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12 December 2020

Inflammatory blockade improves human pancreatic islet function and viability

1 reference

12 December 2020

Refinement of the automated method for human islet isolation and presentation of a closed system for in vitro islet culture

1 reference

12 December 2020

Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation

1 reference

12 December 2020

The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channel

1 reference

12 December 2020

LIVER X RECEPTOR IS A KEY REGULATOR OF CYTOKINE RELEASE IN HUMAN MONOCYTES

1 reference

12 December 2020

Liver X receptors regulate adrenal cholesterol balance

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12 December 2020

10.1007/S00125-009-1366-Z

Identifiers

DOI

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18 December 2017

1 reference

18 December 2017