(Q54590591)

1 June 2018

title

Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling. (English)

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author name string

J L Leahy

2

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V Delghingaro-Augusto

3

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J Moibi

4

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K Soni

5

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M-L Peyot

6

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M Fortier

7

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C Guay

8

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J Lamontagne

9

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A Barbeau

10

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E Przybytkowski

11

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E Joly

12

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P Masiello

13

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S Wang

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G A Mitchell

15

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M Prentki

16

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publication date

26 July 2006

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published in

Diabetologia

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volume

49

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issue

9

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page(s)

2120-2130

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https://scigraph.springernature.com/pub.10.1007/s00125-006-0305-5

exact match

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cites work

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Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes

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A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion

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Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes

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Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats

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The antilipolytic agent 3,5-dimethylpyrazole inhibits insulin release in response to both nutrient secretagogues and cyclic adenosine monophosphate agonists in isolated rat islets

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Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

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Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

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12 December 2020

10.1007/S00125-006-0305-5

Identifiers

DOI

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1 June 2018

PubMed ID

16868750

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1 June 2018