(Q38120289)

29 August 2017

title

Germline pharmacogenetics of paclitaxel for cancer treatment (English)

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29 August 2017

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Daniel L Hertz

1

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29 August 2017

publication date

1 July 2013

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29 August 2017

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29 August 2017

volume

14

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29 August 2017

issue

9

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29 August 2017

page(s)

1065-1084

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Association of Paclitaxel pharmacokinetics with the development of peripheral neuropathy in patients with advanced cancer

29 August 2017

cites work

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MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid

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Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation.

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Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity

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CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel

21 January 2018

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Association of CYP1B1 with hypersensitivity induced by taxane therapy in breast cancer patients

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CYP2C8*3 predicts benefit/risk profile in breast cancer patients receiving neoadjuvant paclitaxel

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21 January 2018

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Structural and functional insights into polymorphic enzymes of cytochrome P450 2C8.

21 January 2018

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Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

21 January 2018

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Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population.

21 January 2018

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Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism

21 January 2018

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Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism

21 January 2018

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Clinical implications of CYP3A polymorphisms

21 January 2018

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Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs

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Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer.

21 January 2018

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CYP3A4*16andCYP3A4*18Alleles Found in East Asians Exhibit Differential Catalytic Activities for Seven CYP3A4 Substrate Drugs

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Genetic variation in ABCB1 influences paclitaxel pharmacokinetics in Japanese patients with ovarian cancer.

21 January 2018

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ABCB1 (MDR 1) polymorphisms and progression-free survival among women with ovarian cancer following paclitaxel/carboplatin chemotherapy.

21 January 2018

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Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia

21 January 2018

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Substrate-dependent effects of human ABCB1 coding polymorphisms

21 January 2018

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G-T haplotype (2677G>T/A and 3435C>T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern

21 January 2018

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mdr-1 single nucleotide polymorphisms in ovarian cancer tissue: G2677T/A correlates with response to paclitaxel chemotherapy

21 January 2018

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ABCB1, FCGR2A, and FCGR3A polymorphisms in patients with HER2-positive metastatic breast cancer who were treated with first-line taxane plus trastuzumab chemotherapy

21 January 2018

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Genetic polymorphisms affecting clinical outcomes in epithelial ovarian cancer patients treated with taxanes and platinum compounds: a Korean population-based study

21 January 2018

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A novel MDR1 G1199T variant alters drug resistance and efflux transport activity of P-glycoprotein in recombinant Hek cells

21 January 2018

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ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel.

21 January 2018

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Haplotype-oriented genetic analysis and functional assessment of promoter variants in the MDR1 (ABCB1) gene.

21 January 2018

1 reference

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs

21 January 2018

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MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer

21 January 2018

1 reference

Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in the human hepatoma cell line, HepG2.

21 January 2018

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Variants in the SLCO1B3 gene: interethnic distribution and association with paclitaxel pharmacokinetics.

21 January 2018

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In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy

21 January 2018

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Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: a Gynecologic Oncology Group study

21 January 2018

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Identification of candidate SNPs for drug induced toxicity from differentially expressed genes in associated tissues

21 January 2018

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Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.

21 January 2018

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Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects

21 January 2018

1 reference

Functional analysis of genetic variations in the 5′-flanking region of the human MDR1 gene

21 January 2018

1 reference

Do beta-tubulin mutations have a role in resistance to chemotherapy?

21 January 2018

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Regulatory polymorphisms in β-tubulin IIa are associated with paclitaxel-induced peripheral neuropathy.

21 January 2018

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Hematologic β-tubulin VI isoform exhibits genetic variability that influences paclitaxel toxicity.

21 January 2018

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CYP1B1 and hormone-induced cancer

21 January 2018

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Docetaxel (Taxotere) is not metabolized by recombinant human CYP1B1 in vitro, but acts as an effector of this isozyme

21 January 2018

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Cytochrome 450 1B1 (CYP1B1) polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC) patients.

21 January 2018

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Association of the CYP1B1*3 allele with survival in patients with prostate cancer receiving docetaxel

21 January 2018

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Genetic predictors of taxane-induced neurotoxicity in a SWOG phase III intergroup adjuvant breast cancer treatment trial (S0221).

21 January 2018

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Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel.

21 January 2018

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GWAS-based association between RWDD3 and TECTA variants and paclitaxel induced neuropathy could not be confirmed in Scandinavian ovarian cancer patients

21 January 2018

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A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.

21 January 2018

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Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H

21 January 2018

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Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy

21 January 2018

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Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel

21 January 2018

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Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer

21 January 2018

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Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/PGS.13.90

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29 August 2017

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