(Q38122244)

29 August 2017

title

The dual function of KSR1: a pseudokinase and beyond (English)

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29 August 2017

Hua Zhang

1

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29 August 2017

Chuay Yeng Koo

series ordinal

2

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29 August 2017

Justin Stebbing

series ordinal

3

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29 August 2017

Georgios Giamas

series ordinal

4

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29 August 2017

publication date

1 August 2013

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Biochemical Society Transactions

29 August 2017

published in

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29 August 2017

volume

41

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29 August 2017

issue

4

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29 August 2017

page(s)

1078-1082

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KSR, a novel protein kinase required for RAS signal transduction

29 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

KSR modulates signal propagation within the MAPK cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

The protein kinase KSR interacts with 14-3-3 protein and Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

KSR stimulates Raf-1 activity in a kinase-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Kinase suppressor of Ras is ceramide-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

A CC-SAM, for coiled coil-sterile α motif, domain targets the scaffold KSR-1 to specific sites in the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

KSR is a scaffold required for activation of the ERK/MAPK module

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Signaling dynamics of the KSR1 scaffold complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

A dimerization-dependent mechanism drives RAF catalytic activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Kinase suppressor of Ras signals through Thr269 of c-Raf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Kinase suppressor of Ras transphosphorylates c-Raf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

KSR1 is required for cell cycle reinitiation following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic Ras-dependent anchorage-independent growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Suppression of Ras/Mapk pathway signaling inhibits Myc-induced lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

Regulation of glucose homeostasis by KSR1 and MARK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130042

21 January 2018

Identifiers

DOI

10.1042/BST20130042

1 reference

29 August 2017

1 reference