(Q38126465)

29 August 2017

title

Engineering subtle targeted mutations into the mouse genome (English)

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29 August 2017

Douglas B Menke

1

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29 August 2017

publication date

30 August 2013

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29 August 2017

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29 August 2017

volume

51

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29 August 2017

issue

9

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29 August 2017

page(s)

605-618

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Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm

29 August 2017

cites work

1 reference

Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development

21 January 2018

1 reference

AlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice

21 January 2018

1 reference

Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy

21 January 2018

1 reference

Phosphorylation of WASp is a key regulator of activity and stability in vivo

21 January 2018

1 reference

Talking about a Revolution

21 January 2018

1 reference

Targeted genome modification in mice using zinc-finger nucleases

21 January 2018

1 reference

Efficient TALEN-mediated gene knockout in livestock

21 January 2018

1 reference

Transposon mutagenesis of baculoviruses: analysis of Trichoplusia ni transposon IFP2 insertions within the FP-locus of nuclear polyhedrosis viruses

21 January 2018

1 reference

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

21 January 2018

1 reference

P-Match: transcription factor binding site search by combining patterns and weight matrices

21 January 2018

1 reference

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

21 January 2018

1 reference

A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly

21 January 2018

1 reference

PiggyBac transposon-mediated, reversible gene transfer in human embryonic stem cells

21 January 2018

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Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

21 January 2018

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Targeting DNA double-strand breaks with TAL effector nucleases

21 January 2018

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Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

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Targeted integration in rat and mouse embryos with zinc-finger nucleases

21 January 2018

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Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes

21 January 2018

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A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

21 January 2018

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

21 January 2018

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Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems

21 January 2018

1 reference

Enhancing the efficiency of introducing precise mutations into the mouse genome by hit and run gene targeting

21 January 2018

1 reference

Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice

21 January 2018

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Targeted mutation of the Hprt gene in mouse embryonic stem cells

21 January 2018

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Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

21 January 2018

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The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse

21 January 2018

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

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Transposon-mediated mutagenesis of a baculovirus

21 January 2018

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The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome

21 January 2018

1 reference

Introduction of hereditary disease-associated mutations into the beta-amyloid precursor protein gene of mouse embryonic stem cells: a comparison of homologous recombination methods

21 January 2018

1 reference

A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency.

21 January 2018

1 reference

Hypomorphic mutations in PGAP2, encoding a GPI-anchor-remodeling protein, cause autosomal-recessive intellectual disability

21 January 2018

1 reference

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

21 January 2018

1 reference

Multisite phosphorylation regulates Bim stability and apoptotic activity

21 January 2018

1 reference

Efficient genome editing in zebrafish using a CRISPR-Cas system

21 January 2018

1 reference

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

21 January 2018

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RNA-programmed genome editing in human cells

21 January 2018

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Virus-free induction of pluripotency and subsequent excision of reprogramming factors

21 January 2018

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Modeling recent human evolution in mice by expression of a selected EDAR variant

21 January 2018

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Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

21 January 2018

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Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination

21 January 2018

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Targeted chromosomal deletions in human cells using zinc finger nucleases

21 January 2018

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TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain

21 January 2018

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piggyBac internal sequences are necessary for efficient transformation of target genomes

21 January 2018

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Chromosomal mobilization and reintegration of Sleeping Beauty and PiggyBac transposons.

21 January 2018

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De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks

21 January 2018

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RNA-guided human genome engineering via Cas9

21 January 2018

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Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

21 January 2018

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Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases

21 January 2018

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Large-scale discovery of enhancers from human heart tissue

21 January 2018

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Short DNA sequences inserted for gene targeting can accidentally interfere with off-target gene expression.

21 January 2018

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Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

21 January 2018

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A TALE nuclease architecture for efficient genome editing

21 January 2018

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Short motif sequences determine the targets of the prokaryotic CRISPR defence system

21 January 2018

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An encyclopedia of mouse DNA elements (Mouse ENCODE).

21 January 2018

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Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4.

21 January 2018

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Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases

21 January 2018

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Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

21 January 2018

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Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases

21 January 2018

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Genome-wide detection and characterization of positive selection in human populations

21 January 2018

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Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism

21 January 2018

1 reference

Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.

21 January 2018

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A conditional knockout resource for the genome-wide study of mouse gene function

21 January 2018

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Two newly identified genetic determinants of pigmentation in Europeans

21 January 2018

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CRISPR-based adaptive immune systems

21 January 2018

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Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

21 January 2018

1 reference

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

21 January 2018

1 reference

An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells

21 January 2018

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Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation.

21 January 2018

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TALEN-mediated editing of the mouse Y chromosome

21 January 2018

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One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

21 January 2018

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Chromosomal transposition of PiggyBac in mouse embryonic stem cells

21 January 2018

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A common variant of HMGA2 is associated with adult and childhood height in the general population

21 January 2018

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Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

21 January 2018

1 reference

C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals

21 January 2018

1 reference

Introduction of precise alterations into the mouse genome with high efficiency by stable tag-exchange gene targeting: implications for gene targeting in ES cells

21 January 2018

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piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

21 January 2018

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Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells

21 January 2018

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piggyBac is a flexible and highly active transposon as compared to sleeping beauty, Tol2, and Mos1 in mammalian cells

21 January 2018

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Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells

21 January 2018

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Different MRF4 knockout alleles differentially disrupt Myf-5 expression: cis-regulatory interactions at the MRF4/Myf-5 locus.

21 January 2018

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Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon

21 January 2018

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Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

21 January 2018

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Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells

21 January 2018

1 reference

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

21 January 2018

1 reference

Targeted mutagenesis of the endogenous mouse Mis gene promoter: in vivo definition of genetic pathways of vertebrate sexual development

21 January 2018

1 reference

7 January 2021

Efficient repetitive alteration of the mouse Huntington's disease gene by management of background in the tag and exchange gene targeting strategy

1 reference

7 January 2021

Generation and analysis of GluR5(Q636R) kainate receptor mutant mice

1 reference

7 January 2021

Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice.

1 reference

7 January 2021

Knockout mice created by TALEN-mediated gene targeting

1 reference

7 January 2021

Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells

1 reference

7 January 2021

Factors affecting the efficiency of introducing precise genetic changes in ES cells by homologous recombination: tag-and-exchange versus the Cre-loxp system

1 reference

7 January 2021

Identifiers

DOI

10.1002/DVG.22422

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29 August 2017

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