(Q38130717)

29 August 2017

Contributions of HIV-1 Nef to immune dysregulation in HIV-infected patients: a therapeutic target? (English)

1 reference

29 August 2017

Wojciech Witkowski

1

1 reference

PubMed ID

23967871

29 August 2017

Bruno Verhasselt

series ordinal

2

1 reference

PubMed ID

23967871

29 August 2017

language of work or name

English

0 references

publication date

23 August 2013

1 reference

Expert Opinion on Therapeutic Targets

29 August 2017

1 reference

29 August 2017

17

1 reference

29 August 2017

11

1 reference

29 August 2017

1345-1356

1 reference

Overview of the current state of the epidemic

29 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Targets for inhibition of HIV replication: entry, enzyme action, release and maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Talk of HIV cure goes viral

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

A long-term latent reservoir for HIV-1: discovery and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 antiretroviral resistance: scientific principles and clinical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Immune reconstitution under antiretroviral therapy: the new challenge in HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

The nephrotoxic effects of HAART.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Drug-induced lipotoxicity: lipodystrophy associated with HIV-1 infection and antiretroviral treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Dysregulation of glucose metabolism in HIV patients: epidemiology, mechanisms, and management

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

The Sydney Blood Bank Cohort: implications for viral fitness as a cause of elite control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Attenuation of multiple Nef functions in HIV-1 elite controllers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Modelling thymic HIV-1 Nef effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV Nef: role in pathogenesis and viral fitness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Role of CD4 receptor down-regulation during HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 Nef impairs MHC class II antigen presentation and surface expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 Nef interferes with host cell motility by deregulation of Cofilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

The functional consequences of delivery of HIV-1 Nef to dendritic cells using an adenoviral vector.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 Nef induces dendritic cell differentiation: a possible mechanism of uninfected CD4(+) T cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Cell biology of HIV-1 infection of macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Cell death mechanisms in HIV-associated dementia: the involvement of syncytia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 Nef triggers macrophage fusion in a p61Hck- and protease-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 nef protein visits B-cells via macrophage nanotubes: a mechanism for AIDS-related lymphoma pathogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

The dendritic cell system and its role in immunogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Dendritic cells and the control of immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

The interaction of HIV with dendritic cells: outcomes and pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Mucosal transmission of human immunodeficiency virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV interactions with monocytes and dendritic cells: viral latency and reservoirs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

DC-SIGN antagonists, a potential new class of anti-infectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Recruitment of HIV and its receptors to dendritic cell-T cell junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

The decreased replicative capacity of simian immunodeficiency virus SIVmac239Delta(nef) is manifest in cultures of immature dendritic cellsand T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Nef is required for efficient HIV-1 replication in cocultures of dendritic cells and lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Comparative proteomic analysis of HIV-1 particles reveals a role for Ezrin and EHD4 in the Nef-dependent increase of virus infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

How HIV takes advantage of the cytoskeleton in entry and replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

A dynamic view of the immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Structure--function relationships in HIV-1 Nef.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Clinical utility of maraviroc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Inhibition of cellular functions of HIV-1 Nef by artificial SH3 domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Synthetic inhibitors of proline-rich ligand-mediated protein-protein interaction: potent analogs of UCS15A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Nanobodies: natural single-domain antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

The role of myristoylation in the interactions between human immunodeficiency virus type I Nef and cellular proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Nef surfaces: where to interfere with function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Src kinase inhibitors: promising cancer therapeutics?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

HIV-1 Nef-Induced Upregulation of DC-SIGN in Dendritic Cells Promotes Lymphocyte Clustering and Viral Spread

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Projected life expectancy of people with HIV according to timing of diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Class of Antiretroviral Drugs and the Risk of Myocardial Infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Long-term symptomless HIV-1 infection in recipients of blood products from a single donor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

Nef does not inhibit F-actin remodelling and HIV-1 cell–cell transmission at the T lymphocyte virological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.830712

10.1517/14728222.2013.830712

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference

PubMed ID

23967871