(Q38137976)

29 August 2017

title

Organ-on-a-chip technology and microfluidic whole-body models for pharmacokinetic drug toxicity screening (English)

1 reference

29 August 2017

0 references

0 references

1 reference

Jong Bum Lee

1

1 reference

29 August 2017

Jong Hwan Sung

series ordinal

2

1 reference

29 August 2017

publication date

23 August 2013

1 reference

29 August 2017

published in

Biotechnology Journal

1 reference

29 August 2017

volume

8

1 reference

29 August 2017

issue

11

1 reference

29 August 2017

page(s)

1258-1266

1 reference

Early prediction of drug metabolism and toxicity: systems biology approach and modeling

29 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

The role of mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modelling in translational research of biologics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Biomolecular gradients in cell culture systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Macro- and microscale fluid flow systems for endothelial cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

The origins and the future of microfluidics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Microengineered physiological biomimicry: organs-on-chips.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Organs-on-a-chip: a focus on compartmentalized microdevices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Biomimetic tissues on a chip for drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Physiologically based pharmacokinetic modelling: a sound mechanistic basis is needed

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Physiologically relevant two-compartment pharmacokinetic models for skin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Integrated pharmacokinetics and pharmacodynamics in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Pharmacokinetic/pharmacodynamic studies in drug product development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Reconstituting organ-level lung functions on a chip

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Investigation into modification of mass transfer kinetics by acrolein in a renal biochip.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Microfluidic Cardiac Cell Culture Model (μCCCM)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

In vitro microscale systems for systematic drug toxicity study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Cell mechanics: integrating cell responses to mechanical stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Analysis of oxygen transport in a diffusion-limited model of engineered heart tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Microengineered hydrogels for tissue engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

PMMA/PDMS valves and pumps for disposable microfluidics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Gravity-induced convective flow in microfluidic systems: electrochemical characterization and application to enzyme-linked immunosorbent assay tests.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Flow rate analysis of a surface tension driven passive micropump.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Design of pressure-driven microfluidic networks using electric circuit analogy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

In vitro perfused human capillary networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Engineering of functional, perfusable 3D microvascular networks on a chip

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

In vitro zonation and toxicity in a hepatocyte bioreactor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Microscale culture of human liver cells for drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Co-culture of epithelial cells and bacteria for investigating host-pathogen interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

SyM-BBB: a microfluidic Blood Brain Barrier model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell-cell interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Three-dimensional cellular microarray for high-throughput toxicology assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

The design and fabrication of three-chamber microscale cell culture analog devices with integrated dissolved oxygen sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Development of a microscale cell culture analog to probe naphthalene toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Connected culture of murine hepatocytes and HUVEC in a multicompartmental bioreactor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Metabolic control through hepatocyte and adipose tissue cross-talk in a multicompartmental modular bioreactor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Engineering challenges for instrumenting and controlling integrated organ-on-chip systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Investigation of portable in situ fluorescence optical detection for microfluidic 3D cell culture assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Real-time fluorescence detection of multiple microscale cell culture analog devices in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

A mini-microscope for in situ monitoring of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

PDMS absorption of small molecules and consequences in microfluidic applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Microfluidic scaffolds for tissue engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Prevention of air bubble formation in a microfluidic perfusion cell culture system using a microscale bubble trap

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Integration of in silico and in vitro platforms for pharmacokinetic-pharmacodynamic modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

Microtechnology for mimicking in vivo tissue environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201300086

21 January 2018

Identifiers

DOI

10.1002/BIOT.201300086

1 reference

29 August 2017

1 reference