(Q38138603)

29 August 2017

title

Pregnane X receptor polymorphisms associated with human diseases (English)

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29 August 2017

3

Stamatios Theocharis

1 reference

29 August 2017

Ioly Kotta-Loizou

1

1 reference

29 August 2017

Efstratios Patsouris

series ordinal

2

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29 August 2017

language of work or name

English

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publication date

8 September 2013

1 reference

Expert Opinion on Therapeutic Targets

29 August 2017

published in

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29 August 2017

volume

17

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29 August 2017

issue

10

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29 August 2017

page(s)

1167-1177

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

29 August 2017

cites work

1 reference

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms.

21 January 2018

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The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

21 January 2018

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PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators

21 January 2018

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

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Structure and function of the human nuclear xenobiotic receptor PXR.

21 January 2018

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

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The PXR ligand-binding domain: how to be picky and promiscuous at the same time.

21 January 2018

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The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

21 January 2018

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Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen

21 January 2018

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Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR.

21 January 2018

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Vitamin E activates gene expression via the pregnane X receptor

21 January 2018

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The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators

21 January 2018

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PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides

21 January 2018

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Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

21 January 2018

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An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

21 January 2018

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

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The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

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PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics

21 January 2018

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

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Regulation of hepatic transporters by xenobiotic receptors

21 January 2018

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Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis.

21 January 2018

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Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Pregnane X receptor is essential for normal progression of liver regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes.

21 January 2018

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Polymorphisms in promiscuous PXR: an explanation for interindividual differences in drug clearance?

21 January 2018

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Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation

21 January 2018

1 reference

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Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Nuclear pregnane X receptor single nucleotide polymorphism (-25385C/T) is not associated with inflammatory bowel disease in pediatric patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.823403

The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease

21 January 2018

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Importance of bile reflux in Barrett's esophagus

21 January 2018

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Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

The influence of common gene variants of the xenobiotic receptor (PXR) in genetic susceptibility to intrahepatic cholestasis of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Antimitochondrial antibodies in primary biliary cirrhosis: the role of xenobiotics

21 January 2018

1 reference

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Immunoreactivity of organic mimeotopes of the E2 component of pyruvate dehydrogenase: connecting xenobiotics with primary biliary cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Immunization with a Xenobiotic 6-Bromohexanoate Bovine Serum Albumin Conjugate Induces Antimitochondrial Antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Polymorphism of antimalaria drug metabolizing, nuclear receptor, and drug transport genes among malaria patients in Zanzibar, East Africa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Polymorphisms of the nuclear receptor pregnane X receptor and organic anion transporter polypeptides 1A2, 1B1, 1B3, and 2B1 are not associated with breast cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

The impact of dietary and lifestyle risk factors on risk of colorectal cancer: a quantitative overview of the epidemiological evidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Cigarette smoking and colorectal cancer incidence and mortality: systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Cigarette smoking and the risk of colorectal cancer: a meta-analysis of prospective cohort studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Polymorphisms of human N-acetyltransferases and cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Cancer and phase II drug-metabolizing enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Role of xenobiotic metabolic enzymes in cancer epidemiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Lack of association of ABCB1 and PXR polymorphisms with response to treatment in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Population pharmacokinetic modeling of the association between 63396C->T pregnane X receptor polymorphism and unboosted atazanavir clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Nuclear receptor-mediated induction of CYP450 by antiretrovirals: functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Explaining variability in ciclosporin exposure in adult kidney transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

A gut feeling of the PXR, PPAR and NF-kappaB connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

Identification of NR1I2 genetic variation using resequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.823403

10.1517/14728222.2013.823403

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference