(Q38147860)

29 August 2017

Drug discovery for autism spectrum disorder: challenges and opportunities (English)

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29 August 2017

autism spectrum disorder

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Anirvan Ghosh

1

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29 August 2017

Aubin Michalon

2

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29 August 2017

Lothar Lindemann

3

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29 August 2017

Paulo Fontoura

4

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29 August 2017

Luca Santarelli

5

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29 August 2017

1 October 2013

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Nature Reviews Drug Discovery

29 August 2017

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29 August 2017

12

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29 August 2017

10

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29 August 2017

777-790

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https://scigraph.springernature.com/pub.10.1038/nrd4102

29 August 2017

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Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function

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Etiological heterogeneity in autism spectrum disorders: more than 100 genetic and genomic disorders and still counting

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31 March 2020

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Network medicine: a network-based approach to human disease

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An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus

31 March 2020

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The Autistic Neuron: Troubled Translation?

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Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model

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Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome.

31 March 2020

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GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism.

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Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

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A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

31 March 2020

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Sirolimus therapy for angiomyolipoma in tuberous sclerosis and sporadic lymphangioleiomyomatosis: a phase 2 trial.

31 March 2020

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Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis

31 March 2020

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Multicenter phase 2 trial of sirolimus for tuberous sclerosis: kidney angiomyolipomas and other tumors regress and VEGF- D levels decrease

31 March 2020

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Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism

31 March 2020

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Mutations causing syndromic autism define an axis of synaptic pathophysiology

31 March 2020

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Synapse dysfunction in autism: a molecular medicine approach to drug discovery in neurodevelopmental disorders

31 March 2020

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Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

31 March 2020

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Investigating synapse formation and function using human pluripotent stem cell-derived neurons

31 March 2020

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Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

31 March 2020

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A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells

31 March 2020

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Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

31 March 2020

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Autism-like behavioral phenotypes in BTBR T+tf/J mice

31 March 2020

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In utero exposure to valproic acid and autism--a current review of clinical and animal studies

31 March 2020

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Behavioural phenotyping assays for mouse models of autism

31 March 2020

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Unusual repertoire of vocalizations in adult BTBR T+tf/J mice during three types of social encounters

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Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism

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Comprehensive analysis of ultrasonic vocalizations in a mouse model of fragile X syndrome reveals limited, call type specific deficits

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Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome

31 March 2020

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The factor structure of autistic traits

31 March 2020

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Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056.

31 March 2020

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Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: a randomized, controlled, phase 2 trial

31 March 2020

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Open-label treatment trial of lithium to target the underlying defect in fragile X syndrome

31 March 2020

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Open-label add-on treatment trial of minocycline in fragile X syndrome

31 March 2020

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A randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with fragile x syndrome

31 March 2020

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Research review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder

31 March 2020

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Reliability of eye tracking and pupillometry measures in individuals with fragile X syndrome

31 March 2020

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Human neuroimaging of oxytocin and vasopressin in social cognition

31 March 2020

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Promoting social behavior with oxytocin in high-functioning autism spectrum disorders

31 March 2020

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Psychometric study of the Aberrant Behavior Checklist in Fragile X Syndrome and implications for targeted treatment

31 March 2020

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Pervasive developmental disorders in preschool children: confirmation of high prevalence

31 March 2020

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Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample

31 March 2020

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Comorbid psychiatric disorders associated with Asperger syndrome/high-functioning autism: a community- and clinic-based study.

31 March 2020

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Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005.

31 March 2020

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Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report

31 March 2020

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Regression in Autistic Spectrum Disorders

31 March 2020

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Epidemiology of Pervasive Developmental Disorders

31 March 2020

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The innovative medicines initiative: a European response to the innovation challenge

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31 March 2020

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EU-AIMS: a boost to autism research.

31 March 2020

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Common genetic variants, acting additively, are a major source of risk for autism

31 March 2020

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Patterns and rates of exonic de novo mutations in autism spectrum disorders

31 March 2020

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Whole-genome sequencing in autism identifies hot spots for de novo germline mutation.

31 March 2020

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Finding the missing heritability of complex diseases

31 March 2020

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Phenotypic heterogeneity of genomic disorders and rare copy-number variants

31 March 2020

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Epigenetic discordance at imprinting control regions in twins

31 March 2020

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Genome-wide association studies for complex traits: consensus, uncertainty and challenges

31 March 2020

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The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders

31 March 2020

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STRING v9.1: protein-protein interaction networks, with increased coverage and integration

31 March 2020

1 reference

FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism

31 March 2020

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A travel guide to Cytoscape plugins

31 March 2020

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Rare and common variants: twenty arguments

31 March 2020

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12 December 2020

Prevalence of autism spectrum disorders--Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008

1 reference

12 December 2020

Translational animal models of autism and neurodevelopmental disorders.

1 reference

12 December 2020

Sensory features and repetitive behaviors in children with autism and developmental delays

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD4102

1 reference

29 August 2017

1 reference