(Q38147906)

29 August 2017

title

Platelet-rich plasma for managing pain and inflammation in osteoarthritis (English)

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29 August 2017

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1

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29 August 2017

Nicola Maffulli

2

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29 August 2017

language of work or name

English

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publication date

1 October 2013

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Nature Reviews Rheumatology

29 August 2017

published in

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29 August 2017

volume

9

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29 August 2017

issue

12

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29 August 2017

page(s)

721-730

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Osteoarthritis: an update with relevance for clinical practice

29 August 2017

cites work

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Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis

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Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip.

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21 January 2018

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Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial.

21 January 2018

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Proteomic analysis of platelet alpha-granules using mass spectrometry

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Platelets: production, morphology and ultrastructure

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The platelet release reaction: just when you thought platelet secretion was simple

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Tendon healing and platelet-rich plasma therapies

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Dynamics of neutrophil extravasation and vascular permeability are uncoupled during aseptic cutaneous wounding

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Platelet-derived chemokines: pathophysiology and therapeutic aspects

21 January 2018

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The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer

21 January 2018

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Proteomics strategy for identifying candidate bioactive proteins in complex mixtures: application to the platelet releasate

21 January 2018

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CXC chemokine ligand 4 induces a unique transcriptome in monocyte-derived macrophages

21 January 2018

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Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis

21 January 2018

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CD40 ligand: a neo-inflammatory molecule in vascular diseases

21 January 2018

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Platelets, inflammation and tissue regeneration

21 January 2018

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Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis

21 January 2018

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Controlling the angiogenic switch: a balance between two distinct TGF-b receptor signaling pathways

21 January 2018

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Secretion of fibrinolytic enzymes facilitates human mesenchymal stem cell invasion into fibrin clots

21 January 2018

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Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity

21 January 2018

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Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Sterile inflammation: sensing and reacting to damage

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

NF-kappaB signaling: multiple angles to target OA.

21 January 2018

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Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogen-activated protein kinases and nuclear factor-κB in human osteoarthritis chondrocyt

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

The IKK-NF-kappaB pathway: a source for novel molecular drug targets in pain therapy?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Molecular basis of anti-inflammatory action of platelet-rich plasma on human chondrocytes: mechanisms of NF-κB inhibition via HGF.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Regenerative potentials of platelet-rich plasma enhanced by collagen in retrieving pro-inflammatory cytokine-inhibited chondrogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Fibroblastic response to treatment with different preparations rich in growth factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

An in vitro evaluation of the anti-inflammatory effects of platelet-rich plasma, ketorolac, and methylprednisolone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Platelet-rich plasma increases matrix metalloproteinases in cultures of human synovial fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Angiogenesis in osteoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Synovial concentrations of the angiogenic peptides bFGF and VEGF do not discriminate rheumatoid arthritis from other forms of inflammatory arthritis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

The pro-forms of insulin-like growth factor I (IGF-I) are predominant in skeletal muscle and alter IGF-I receptor activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Making sense of latent TGFbeta activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Age-dependent alteration of TGF-β signalling in osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Relationship between Investigative Biomarkers and Radiographic Grading in Patients with Knee Osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

The effect of platelet rich plasma combined with microfractures on the treatment of chondral defects: an experimental study in a sheep model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Human platelet-rich plasma stimulates migration and chondrogenic differentiation of human subchondral progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Time-sequential modulation in expression of growth factors from platelet-rich plasma (PRP) on the chondrocyte cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Effect of human platelet supernatant on proliferation and matrix synthesis of human articular chondrocytes in monolayer and three-dimensional alginate cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Influence of platelet-rich plasma on chondrogenic differentiation and proliferation of chondrocytes and mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Platelet lysate favours in vitro expansion of human bone marrow stromal cells for bone and cartilage engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

The regenerative effect of platelet-rich plasma on healing in large osteochondral defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Platelet autologous growth factors decrease the osteochondral regeneration capability of a collagen-hydroxyapatite scaffold in a sheep model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

The effect of platelet-rich plasma on the regenerative therapy of muscle derived stem cells for articular cartilage repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Synovial membrane-derived mesenchymal stem cells supported by platelet-rich plasma can repair osteochondral defects in a rabbit model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

A cell-free scaffold-based cartilage repair provides improved function hyaline-like repair at one year.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

A novel biological approach to treat chondromalacia patellae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Platelet-rich plasma treatment in symptomatic patients with knee osteoarthritis: preliminary results in a group of active patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Comparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

The positive effects of different platelet-rich plasma methods on human muscle, bone, and tendon cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Synovial fluid cell analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Autologous platelets as a source of proteins for healing and tissue regeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Microparticles from apoptotic platelets promote resident macrophage differentiation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Platelets display potent antimicrobial activity and release human beta-defensin 2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Interaction of PF4 (CXCL4) with the vasculature: a role in atherosclerosis and angiogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Platelet-rich plasma releasate inhibits inflammatory processes in osteoarthritic chondrocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Intraarticular injection of platelet-rich plasma reduces inflammation in a pig model of rheumatoid arthritis of the knee joint

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

The splice variants VEGF121 and VEGF189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Normal ranges of angiogenesis regulatory proteins in human platelets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Functional interactions between matrix metalloproteinases and glycosaminoglycans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Ten years in the life of an enzyme: the story of the human MMP-13 (collagenase-3).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Repeated platelet concentrate injections enhance reparative response of microfractures in the treatment of chondral defects of the knee: an experimental study in an animal model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Stromal-cell-derived factor (SDF) 1-alpha in combination with BMP-2 and TGF-β1 induces site-directed cell homing and osteogenic and chondrogenic differentiation for tissue engineering without the requirement for cell seeding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-derived scaffold for cartilage regeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Expansion of adipose tissue mesenchymal stromal progenitors in serum-free medium supplemented with virally inactivated allogeneic human platelet lysate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Is platelet-rich plasma able to enhance the results of arthroscopic microfracture in early osteoarthritis and cartilage lesion over 40 years of age?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Mesenchymal stem cell injections improve symptoms of knee osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Platelet-rich plasma or hyaluronate in the management of osteochondral lesions of the talus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Platelet-rich plasma in patients with tibiofemoral cartilage degeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

Growth factor and catabolic cytokine concentrations are influenced by the cellular composition of platelet-rich plasma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.141

The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages

31 March 2020

1 reference

12 December 2020

Chondrocyte innate immune myeloid differentiation factor 88-dependent signaling drives procatabolic effects of the endogenous Toll-like receptor 2/Toll-like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal p

1 reference

12 December 2020

Intraarticular administration of platelet-rich plasma with biodegradable gelatin hydrogel microspheres prevents osteoarthritis progression in the rabbit knee.

1 reference

12 December 2020

Autologous platelets as a source of proteins for healing and tissue regeneration

1 reference

12 December 2020

Treatment of knee joint osteoarthritis with autologous platelet-rich plasma in comparison with hyaluronic acid

1 reference

12 December 2020

High throughput generated micro-aggregates of chondrocytes stimulate cartilage formation in vitro and in vivo.

1 reference

12 December 2020

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

1 reference

12 December 2020

Effect of autologous platelet-rich plasma on the repair of full-thickness articular defects in rabbits.

1 reference

12 December 2020

Platelets and wound healing

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2013.141

1 reference

Dimensions Publication ID

29 August 2017

1012054256

0 references

1 reference