(Q38148981)

29 August 2017

title

E6AP in the brain: one protein, dual function, multiple diseases (English)

1 reference

29 August 2017

Jimmy El Hokayem

1

1 reference

29 August 2017

Zafar Nawaz

series ordinal

2

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29 August 2017

publication date

5 October 2013

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29 August 2017

published in

Molecular Neurobiology

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29 August 2017

volume

49

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29 August 2017

issue

2

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29 August 2017

page(s)

827-839

1 reference

https://scigraph.springernature.com/pub.10.1007/s12035-013-8563-y

29 August 2017

exact match

0 references

cites work

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Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins

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Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53

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Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity

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Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

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UBE3A/E6-AP mutations cause Angelman syndrome

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Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination

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The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoprotein.

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Myc and human papillomavirus type 16 E7 genes cooperate to immortalize human keratinocytes

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21 January 2018

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The ubiquitin-protein ligase E6-associated protein (E6-AP) serves as its own substrate

21 January 2018

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21 January 2018

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HPV16-E6 associated hTERT promoter acetylation is E6AP dependent, increased in later passage cells and enhanced by loss of p300.

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21 January 2018

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Lives and times of nuclear receptors

21 January 2018

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Proteasome-dependent degradation of the human estrogen receptor

21 January 2018

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The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation

21 January 2018

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Decreased expression of e6-associated protein in breast and prostate carcinomas

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

E6AP mediates regulated proteasomal degradation of the nuclear receptor coactivator amplified in breast cancer 1 in immortalized cells.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Dynamic combinatorial networks in nuclear receptor-mediated transcription

21 January 2018

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Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons

21 January 2018

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Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a

21 January 2018

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Spatial and temporal silencing of the human maternal UBE3A gene

21 January 2018

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21 January 2018

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Regulation of turnover of tumor suppressor p53 and cell growth by E6-AP, a ubiquitin protein ligase mutated in Angelman mental retardation syndrome.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

E6-AP promotes misfolded polyglutamine proteins for proteasomal degradation and suppresses polyglutamine protein aggregation and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Sacsinopathies: sacsin-related ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Genetic ablation of the steroid receptor coactivator-ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Nuclear receptor coregulators are new players in nervous system development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Drosophila Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase I activity via a non-ubiquitin ligase mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Defective glucocorticoid hormone receptor signaling leads to increased stress and anxiety in a mouse model of Angelman syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Genome-wide gene expression profiling of the Angelman syndrome mice with Ube3a mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

A Drosophila model for Angelman syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

The Drosophila homologue of the Angelman syndrome ubiquitin ligase regulates the formation of terminal dendritic branches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Ube3a is required for experience-dependent maturation of the neocortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Analysis of cerebellar function in Ube3a-deficient mice reveals novel genotype-specific behaviors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Distinct phenotypes distinguish the molecular classes of Angelman syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Phenotypic variability in Angelman syndrome: comparison among different deletion classes and between deletion and UPD subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Fast oscillation in the cerebellar cortex of calcium binding protein-deficient mice: a new sensorimotor arrest rhythm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Loss of dopaminergic neurons and resulting behavioural deficits in mouse model of Angelman syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Developmental sensory experience balances cortical excitation and inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Puppet-like syndrome of Angelman: a pathologic and neurochemical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Impairment of TrkB-PSD-95 signaling in Angelman syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

ARSACS, a spastic ataxia common in northeastern Québec, is caused by mutations in a new gene encoding an 11.5-kb ORF

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Neurobehavioral and electroencephalographic abnormalities in Ube3a maternal-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Angelman syndrome: a review of the clinical and genetic aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Are there distinctive sleep problems in Angelman syndrome?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Neurons but not glial cells show reciprocal imprinting of sense and antisense transcripts of Ube3a

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Impaired hippocampal plasticity and altered neurogenesis in adult Ube3a maternal deficient mouse model for Angelman syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Neurological aspects of the Angelman syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Molecular epigenetics of Angelman syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Rett syndrome: from the gene to the disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

MeCP2 dysfunction in Rett syndrome and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Ube3a expression is not altered in Mecp2 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Imprinting in Angelman and Prader-Willi syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Towards a molecular understanding of Prader-Willi and Angelman syndromes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Autism in Angelman syndrome: implications for autism research.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Autism spectrum disorders in Prader-Willi and Angelman syndromes: a systematic review

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Update on autism: A review of 1300 reports published in 2008

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Autism spectrum disorder: diagnosis and management

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

21 January 2018

Neuroimaging of autism

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Genetics of childhood disorders: XLVII. Autism, part 6: duplication and inherited susceptibility of chromosome 15q11-q13 genes in autism.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

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Trinucleotide Repeat Disorders

21 January 2018

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Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Dysfunction of the ubiquitin ligase Ube3a may be associated with synaptic pathophysiology in a mouse model of Huntington disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8563-Y

Postural rhythmic muscle bursting activity in Angelman syndrome

21 January 2018

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12 December 2020

Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome.

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12 December 2020

E6-associated protein (E6-AP) is a dual function coactivator of steroid hormone receptors

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12 December 2020

The stability of the human papillomavirus E6 oncoprotein is E6AP dependent

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12 December 2020

E6-AP facilitates efficient transcription at estrogen responsive promoters through recruitment of chromatin modifiers

1 reference

12 December 2020

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown

1 reference

12 December 2020

The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region

1 reference

12 December 2020

Autism or atypical autism in maternally but not paternally derived proximal 15q duplication

1 reference

12 December 2020

Kinetic analysis of the interactions of human papillomavirus E6 oncoproteins with the ubiquitin ligase E6AP using surface plasmon resonance

1 reference

12 December 2020

Levodopa responsive Parkinsonism in adults with Angelman Syndrome

1 reference

12 December 2020

10.1007/S12035-013-8563-Y

Identifiers

DOI

1 reference

Dimensions Publication ID

29 August 2017

1016892071

0 references

1 reference