(Q45288517)

11 December 2017

E6-AP promotes misfolded polyglutamine proteins for proteasomal degradation and suppresses polyglutamine protein aggregation and toxicity (English)

1 reference

11 December 2017

1 reference

Amit Mishra

1

1 reference

11 December 2017

Priyanka Dikshit

2

1 reference

11 December 2017

Sudarshana Purkayastha

3

1 reference

11 December 2017

Jaiprakash Sharma

4

1 reference

11 December 2017

Nobuyuki Nukina

5

1 reference

11 December 2017

Nihar Ranjan Jana

6

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11 December 2017

language of work or name

English

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publication date

17 January 2008

1 reference

Journal of Biological Chemistry

11 December 2017

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11 December 2017

283

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11 December 2017

12

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11 December 2017

7648-7656

1 reference

Glutamine repeats and neurodegeneration

11 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

C. elegans cell cycles: invariance and stem cell divisions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Therapeutics development for triplet repeat expansion diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Dysfunction of wild-type huntingtin in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Wild-type huntingtin plays a role in brain development and neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Huntington's disease: the challenge for cell biologists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Polyglutamine fibrillogenesis: the pathway unfolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Recent advances in understanding the pathogenesis of polyglutamine diseases: involvement of molecular chaperones and ubiquitin-proteasome pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Transcriptional dysregulation in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

The roles of intracellular protein-degradation pathways in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

In vivo evidence of CHIP up-regulation attenuating tau aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

The co-chaperone CHIP is induced in various stresses and confers protection to cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

The ubiquitin-protein ligase E6-associated protein (E6-AP) serves as its own substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706620200

21 January 2018

Identifiers

DOI

10.1074/JBC.M706620200

1 reference

11 December 2017

1 reference