(Q45298680)

11 December 2017

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo (English)

1 reference

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12 May 2020

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4

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12 May 2020

author name string

Victor M Miller

1

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12 May 2020

Rick F Nelson

2

1 reference

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12 May 2020

Cynthia M Gouvion

3

1 reference

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12 May 2020

Edgardo Rodriguez-Lebron

5

1 reference

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12 May 2020

Scott Q Harper

6

1 reference

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12 May 2020

Beverly L Davidson

7

1 reference

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12 May 2020

Michael R Rebagliati

8

1 reference

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12 May 2020

Henry L Paulson

9

1 reference

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12 May 2020

language of work or name

English

0 references

publication date

1 October 2005

1 reference

11 December 2017

Journal of Neuroscience

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12 May 2020

volume

25

1 reference

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12 May 2020

page(s)

9152-9161

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12 May 2020

issue

40

1 reference

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Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

12 May 2020

cites work

1 reference

12 December 2020

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

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12 December 2020

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

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12 December 2020

Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

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12 December 2020

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

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12 December 2020

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

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12 December 2020

Genetic suppression of polyglutamine toxicity in Drosophila

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12 December 2020

Delaying the onset of Huntington's in mice

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12 December 2020

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

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12 December 2020

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

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12 December 2020

Glutamine repeats and neurodegeneration

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12 December 2020

Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease

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12 December 2020

Effective targeted gene 'knockdown' in zebrafish

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12 December 2020

Identification of genes that modify ataxin-1-induced neurodegeneration.

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12 December 2020

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

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12 December 2020

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

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12 December 2020

Impairment of the ubiquitin-proteasome system by protein aggregation

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12 December 2020

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

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12 December 2020

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

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12 December 2020

Suppression of heat shock transcription factor HSF1 in zebrafish causes heat-induced apoptosis

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12 December 2020

CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

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12 December 2020

Molecular chaperones in the cytosol: from nascent chain to folded protein

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12 December 2020

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

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12 December 2020

Toxic proteins in neurodegenerative disease

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12 December 2020

Protein quality control: U-box-containing E3 ubiquitin ligases join the fold

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12 December 2020

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

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12 December 2020

Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila

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12 December 2020

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

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12 December 2020

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

1 reference

12 December 2020

Zebrafish: from disease modeling to drug discovery.

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12 December 2020

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

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12 December 2020

Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

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12 December 2020

Overexpression of the cochaperone CHIP enhances Hsp70-dependent folding activity in mammalian cells.

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12 December 2020

Culturing hippocampal and cortical neurons

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12 December 2020

CHIP activates HSF1 and confers protection against apoptosis and cellular stress

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12 December 2020

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

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12 December 2020

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

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12 December 2020

Molecular clearance of ataxin-3 is regulated by a mammalian E4

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12 December 2020

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

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12 December 2020

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

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12 December 2020

Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

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12 December 2020

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

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12 December 2020

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.

1 reference

12 December 2020

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

1 reference

12 December 2020

Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

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12 December 2020

A system for characterizing cellular and molecular events in programmed neuronal cell death.

1 reference

12 December 2020

Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2.

1 reference

12 December 2020

Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells

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12 December 2020

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

1 reference

12 December 2020

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

1 reference

12 December 2020

10.1523/JNEUROSCI.3001-05.2005

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725774&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725774&resulttype=core&format=json

12 May 2020

1 reference