(Q38150426)

29 August 2017

title

Doxorubicin-induced death in tumour cells and cardiomyocytes: is autophagy the key to improving future clinical outcomes? (English)

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29 August 2017

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Oktay Tacar

1

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29 August 2017

Crispin R Dass

series ordinal

2

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29 August 2017

publication date

18 September 2013

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Journal of Pharmacy and Pharmacology

29 August 2017

published in

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29 August 2017

volume

65

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29 August 2017

issue

11

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29 August 2017

page(s)

1577-1589

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Rules for making human tumor cells

29 August 2017

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Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death

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Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells

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Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo.

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Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase-3 activation in a Fas-independent way.

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Caspase inhibition switches doxorubicin-induced apoptosis to senescence

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Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. intermediacy of H(2)O(2)- and p53-dependent pathways

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Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats

21 January 2018

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IkappaBalpha gene therapy in tumor necrosis factor-alpha- and chemotherapy-mediated apoptosis of hepatocellular carcinomas

21 January 2018

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Doxorubicin: the good, the bad and the ugly effect

21 January 2018

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The hepatic pharmacokinetics of doxorubicin and liposomal doxorubicin

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Pharmacogenetics of target genes across doxorubicin disposition pathway: a review

21 January 2018

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Review: doxorubicin delivery systems based on chitosan for cancer therapy.

21 January 2018

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Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity

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Mitochondrial DNA is a direct target of anti-cancer anthracycline drugs

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Doxorubicin increases the susceptibility of brain mitochondria to Ca(2+)-induced permeability transition and oxidative damage

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Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells

21 January 2018

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The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

21 January 2018

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 January 2018

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AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes

21 January 2018

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Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress

21 January 2018

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AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase

21 January 2018

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Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells

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Doxorubicin-induced apoptosis and chemosensitivity in hepatoma cell lines.

21 January 2018

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Blinded by the Light: The Growing Complexity of p53

21 January 2018

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21 January 2018

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Paradoxical suppression of cellular senescence by p53

21 January 2018

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Weak p53 permits senescence during cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Induction of cellular senescence by doxorubicin is associated with upregulated miR-375 and induction of autophagy in K562 cells

21 January 2018

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Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1.

21 January 2018

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p53 determines multidrug sensitivity of childhood neuroblastoma

21 January 2018

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Bcl-2 family members: dual regulators of apoptosis and autophagy

21 January 2018

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21 January 2018

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Bcl-2 expression as a predictive marker of hormone-refractory prostate cancer treated with taxane-based chemotherapy.

21 January 2018

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Fas/FasL-dependent and -independent activation of caspase-8 in doxorubicin-treated human breast cancer MCF-7 cells: ADAM10 down-regulation activates Fas/FasL signaling pathway

21 January 2018

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJPHP.12144

Life and death partners: apoptosis, autophagy and the cross-talk between them

21 January 2018

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Self-eating and self-killing: crosstalk between autophagy and apoptosis

21 January 2018

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Crosstalk between apoptosis and autophagy within the Beclin 1 interactome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Beclin 1 bridges autophagy, apoptosis and differentiation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJPHP.12144

Partial Beclin 1 silencing aggravates doxorubicin- and Fas-induced apoptosis in HepG2 cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJPHP.12144

Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Neuregulin-1 attenuates doxorubicin-induced autophagy in neonatal rat cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Induction of caspase-independent apoptosis in H9c2 cardiomyocytes by adriamycin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Is caspase-dependent apoptosis only cell differentiation taken to the extreme?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

The role of caspase-2 in stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

A tumor suppressor function for caspase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Induction of caspase-2 activation by a DNA enzyme evokes tumor cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Dz13, a c-jun DNAzyme, is a potent inducer of caspase-2 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Autophagy in ischemic heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJPHP.12144

21 January 2018

Identifiers

DOI

10.1111/JPHP.12144

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29 August 2017

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