(Q38010956)

26 August 2017

title

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology (English)

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26 August 2017

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1

Bradley T Hyman

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26 August 2017

Junying Yuan

2

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26 August 2017

language of work or name

English

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publication date

18 May 2012

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Nature Reviews Neuroscience

26 August 2017

published in

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26 August 2017

volume

13

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26 August 2017

issue

6

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26 August 2017

page(s)

395-406

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Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

26 August 2017

cites work

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Apoptosis in the nervous system

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

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The Jekyll and Hyde functions of caspases

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RAIDD is a new 'death' adaptor molecule

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BAX is required for neuronal death after trophic factor deprivation and during development

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BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

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Caspase inhibition extends the commitment to neuronal death beyond cytochrome c release to the point of mitochondrial depolarization

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Mitogenic signaling from apoptotic cells in Drosophila.

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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

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Differential requirement for caspase 9 in apoptotic pathways in vivo.

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Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

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Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia

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Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy.

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Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

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Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.

31 March 2020

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Necroptosis as an alternative form of programmed cell death

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Molecular mechanisms of necroptosis: an ordered cellular explosion

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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

31 March 2020

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Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning

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Local caspase activity directs engulfment of dendrites during pruning.

31 March 2020

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Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1.

31 March 2020

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Dynamic role of postsynaptic caspase-3 and BIRC4 in zebra finch song-response habituation

31 March 2020

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Caspase-9 activation revealed by semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb.

31 March 2020

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Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity

31 March 2020

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Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.

31 March 2020

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Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission.

31 March 2020

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XIAP as a ubiquitin ligase in cellular signaling

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Regulation of apoptosis by XIAP ubiquitin-ligase activity

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Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spines

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Protein degradation by the proteasome is required for synaptic tagging and the heterosynaptic stabilization of hippocampal late-phase long-term potentiation.

31 March 2020

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A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing

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Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke

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Function of BID -- a molecule of the bcl-2 family -- in ischemic cell death in the brain

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BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia

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Specific caspase pathways are activated in the two stages of cerebral infarction.

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Caspase inhibitors reduce neuronal injury after focal but not global cerebral ischemia in rats

31 March 2020

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Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain

31 March 2020

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Cleaved caspase-3 expression after experimental stroke exhibits different phenotypes and is predominantly non-apoptotic

31 March 2020

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Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis

31 March 2020

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Caspase-3 cleaved spectrin colocalizes with neurofilament-immunoreactive neurons in Alzheimer's disease

31 March 2020

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The role of caspase cleavage of tau in Alzheimer disease neuropathology

31 March 2020

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Caspase-mediated degeneration in Alzheimer's disease

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Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?

31 March 2020

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Caspase activation in the limbic cortex of subjects with early Alzheimer's disease

31 March 2020

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Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

31 March 2020

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain

31 March 2020

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Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease

31 March 2020

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Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

31 March 2020

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Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

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Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease

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Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels

31 March 2020

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Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence

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Caspase activation precedes and leads to tangles

31 March 2020

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Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy

31 March 2020

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Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation

31 March 2020

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Activation of caspase-6 in aging and mild cognitive impairment

31 March 2020

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Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease

31 March 2020

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Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease

31 March 2020

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Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease.

31 March 2020

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Caspase activation without apoptosis: insight into Aβ initiation of neurodegeneration.

31 March 2020

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Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation

31 March 2020

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Convergence of amyloid-beta and tau pathologies on mitochondria in vivo

31 March 2020

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Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex.

31 March 2020

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Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

31 March 2020

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In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.

31 March 2020

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Insights into amyloid-beta-induced mitochondrial dysfunction in Alzheimer disease

31 March 2020

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31 March 2020

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Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease

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Tau suppression in a neurodegenerative mouse model improves memory function

31 March 2020

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Neuronal caspase-3 signaling: not only cell death

31 March 2020

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Synaptic and neuritic alterations during the progression of Alzheimer's disease

31 March 2020

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Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

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DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia

31 March 2020

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Caspase inhibitors attenuate 1-methyl-4-phenylpyridinium toxicity in primary cultures of mesencephalic dopaminergic neurons.

31 March 2020

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Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models

31 March 2020

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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

31 March 2020

1 reference

Induction of apoptosis in cells expressing exogenous Hippi, a molecular partner of huntingtin-interacting protein Hip1

31 March 2020

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Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure.

31 March 2020

1 reference

Caspase levels and execution efficiencies determine the apoptotic potential of the cell

31 March 2020

1 reference

For synapses, it's depression not death.

31 March 2020

1 reference

Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22595785

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Decreased apoptosis in proliferative and postmitotic regions of the Caspase 3-deficient embryonic central nervous system

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22595785

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Caspase-cleaved TAR DNA-binding protein-43 in Pick's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22595785

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRN3228

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Dimensions Publication ID

26 August 2017

1033822251

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1 reference