(Q38151473)

29 August 2017

T-bet: a bridge between innate and adaptive immunity (English)

1 reference

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13 May 2020

1

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13 May 2020

Graham M Lord

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6290922&resulttype=core&format=json

13 May 2020

2

Laurie H Glimcher

1 reference

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13 May 2020

publication date

11 October 2013

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Nature Reviews Immunology

29 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6290922&resulttype=core&format=json

13 May 2020

volume

13

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13 May 2020

issue

11

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13 May 2020

page(s)

777-789

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https://scigraph.springernature.com/pub.10.1038/nri3536

13 May 2020

exact match

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cites work

Origin and evolution of the adaptive immune system: genetic events and selective pressures

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Dual nature of the adaptive immune system in lampreys

31 March 2020

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Evolution of developmental functions by the Eomesodermin, T-brain-1, Tbx21 subfamily of T-box genes: insights from amphioxus

31 March 2020

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T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements.

31 March 2020

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STATs shape the active enhancer landscape of T cell populations

31 March 2020

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A validated regulatory network for Th17 cell specification

31 March 2020

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The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma

31 March 2020

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The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses

31 March 2020

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Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types

31 March 2020

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Master transcription factors and mediator establish super-enhancers at key cell identity genes

31 March 2020

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T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

31 March 2020

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T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells

31 March 2020

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The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells

31 March 2020

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Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells

31 March 2020

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Transcriptional regulation of the mucosal immune system mediated by T-bet.

31 March 2020

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Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue.

31 March 2020

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Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system

31 March 2020

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Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis

31 March 2020

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Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells

31 March 2020

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Inflammatory bowel disease--live transmission

31 March 2020

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The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

31 March 2020

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The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.

31 March 2020

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Innate lymphoid cells: emerging insights in development, lineage relationships, and function

31 March 2020

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Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

31 March 2020

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Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells

31 March 2020

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Innate lymphoid cells--a proposal for uniform nomenclature

31 March 2020

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Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes

31 March 2020

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Distinct requirements for T-bet in gut innate lymphoid cells

31 March 2020

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A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells

31 March 2020

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The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation

31 March 2020

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T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells

31 March 2020

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T-bet plays a key role in NK-mediated control of melanoma metastatic disease

31 March 2020

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T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells

31 March 2020

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The development of airway hyperreactivity in T-bet-deficient mice requires CD1d-restricted NKT cells.

31 March 2020

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T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells

31 March 2020

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Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells

31 March 2020

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A novel transcription factor, T-bet, directs Th1 lineage commitment

31 March 2020

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T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

31 March 2020

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T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.

31 March 2020

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STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms

31 March 2020

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Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection.

31 March 2020

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Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production

31 March 2020

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Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

31 March 2020

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T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

31 March 2020

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Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.

31 March 2020

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Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12.

31 March 2020

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Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination

31 March 2020

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Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

31 March 2020

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miR-29ab1 deficiency identifies a negative feedback loop controlling Th1 bias that is dysregulated in multiple sclerosis

31 March 2020

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MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells

31 March 2020

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Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet

31 March 2020

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Molecular mechanisms by which T-bet regulates T-helper cell commitment

31 March 2020

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Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression

31 March 2020

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Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression

31 March 2020

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T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes.

31 March 2020

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Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli

31 March 2020

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Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells

31 March 2020

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A distal conserved sequence element controls Ifng gene expression by T cells and NK cells.

31 March 2020

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Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction

31 March 2020

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Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

31 March 2020

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CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus

31 March 2020

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T-bet is required for optimal proinflammatory CD4+ T-cell trafficking.

31 March 2020

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The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

31 March 2020

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T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

31 March 2020

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IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508.

31 March 2020

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Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.

31 March 2020

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Fate mapping of IL-17-producing T cells in inflammatory responses

31 March 2020

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Induction and molecular signature of pathogenic TH17 cells

31 March 2020

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Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

31 March 2020

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T-bet is essential for encephalitogenicity of both Th1 and Th17 cells

31 March 2020

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Late developmental plasticity in the T helper 17 lineage

31 March 2020

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Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage

31 March 2020

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Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

31 March 2020

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Early Th1 cell differentiation is marked by a Tfh cell-like transition

31 March 2020

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The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns

31 March 2020

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Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile

31 March 2020

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Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells

31 March 2020

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The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology

31 March 2020

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T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2

31 March 2020

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The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

31 March 2020

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Antigen-driven effector CD8 T cell function regulated by T-bet

31 March 2020

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Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

31 March 2020

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Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin.

31 March 2020

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Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

31 March 2020

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Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation

31 March 2020

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Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells

31 March 2020

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Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor

31 March 2020

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Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T cell differentiation

31 March 2020

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The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

31 March 2020

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Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division

31 March 2020

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Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells.

31 March 2020

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Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.

31 March 2020

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Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells.

31 March 2020

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Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

31 March 2020

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Redefining chronic viral infection

31 March 2020

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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

31 March 2020

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Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.

31 March 2020

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Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.

31 March 2020

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Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection

31 March 2020

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Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection.

31 March 2020

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Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.

31 March 2020

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The Ets-1 transcription factor is required for Stat1-mediated T-bet expression and IgG2a class switching in mouse B cells

31 March 2020

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T-bet regulates IgG class switching and pathogenic autoantibody production

31 March 2020

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Stat1-dependent synergistic activation of T-bet for IgG2a production during early stage of B cell activation

31 March 2020

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Induction of IgG2a class switching in B cells by IL-27.

31 March 2020

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Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα

31 March 2020

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CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI3536

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6290922&resulttype=core&format=json

Dimensions Publication ID

13 May 2020

0 references

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6290922&resulttype=core&format=json

13 May 2020

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