(Q38171466)

30 August 2017

title

The roles of extracellular vesicles in cancer biology: toward the development of novel cancer biomarkers (English)

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30 August 2017

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extracellular vesicle

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3

Takahiro Ochiya

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30 August 2017

2

Nobuyoshi Kosaka

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30 August 2017

1

Takeshi Katsuda

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30 August 2017

language of work or name

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1 March 2014

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30 August 2017

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30 August 2017

volume

14

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30 August 2017

issue

4-5

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30 August 2017

page(s)

412-425

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30 August 2017

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Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes

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Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells.

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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

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Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells

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Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes

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Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

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Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

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LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation

21 January 2018

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Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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Functional delivery of viral miRNAs via exosomes

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Secretory mechanisms and intercellular transfer of microRNAs in living cells

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Therapeutic potential of mesenchymal stem cell-derived microvesicles.

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The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles

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Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes

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microRNA as a new immune-regulatory agent in breast milk

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Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells

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Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas

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Amphiregulin exosomes increase cancer cell invasion.

21 January 2018

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Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

21 January 2018

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Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation

21 January 2018

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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

21 January 2018

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Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth

21 January 2018

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Cancer immunoediting: from immunosurveillance to tumor escape

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The three Es of cancer immunoediting

21 January 2018

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Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

21 January 2018

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More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells

21 January 2018

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Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumour immunity.

21 January 2018

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Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells

21 January 2018

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Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles.

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201300389

Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis

21 January 2018

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Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201300389

Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201300389

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-beta1.

21 January 2018

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Induction of myeloid-derived suppressor cells by tumor exosomes

21 January 2018

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Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells

21 January 2018

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Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg).

21 January 2018

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Tumor angiogenesis: therapeutic implications

21 January 2018

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21 January 2018

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A review of Judah Folkman's remarkable achievements in biomedicine

21 January 2018

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Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201300389

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Dll4-Notch signaling as a therapeutic target in tumor angiogenesis

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201300389

New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201300389

Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201300389

Hypoxia is important in the biology and aggression of human glial brain tumors.

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201300389

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Signaling of the tissue factor coagulation pathway in angiogenesis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

MiR-210--micromanager of the hypoxia pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Hypoxic enhancement of exosome release by breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Tumor stroma and regulation of cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Epithelial-mesenchymal transitions in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Bone marrow-derived cells and tumor growth: contribution of bone marrow-derived cells to tumor micro-environments with special focus on mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Competitive interactions of cancer cells and normal cells via secretory microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Regulation of the tumor suppressor PTEN through exosomes: a diagnostic potential for prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

The role of stromal myofibroblast and extracellular matrix in tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Cancer exosomes trigger fibroblast to myofibroblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

CD44v6 dependence of premetastatic niche preparation by exosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Exosomal tumor microRNA modulates premetastatic organ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Cancer cells induced to express mesenchymal phenotype release exosome-like extracellular vesicles carrying tissue factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Oncogenic H-ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Modulation of B-cell exosome proteins by gamma herpesvirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Medulloblastoma exosome proteomics yield functional roles for extracellular vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Proteome profiling of neuroblastoma-derived exosomes reveal the expression of proteins potentially involved in tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Identification and characterization of proteins isolated from microvesicles derived from human lung cancer pleural effusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Management of cancer of the prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Identification of extracellular delta-catenin accumulation for prostate cancer detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Exosomal microRNA: a diagnostic marker for lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Proteomic analysis of microvesicles derived from human colorectal cancer ascites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Changes in circulating microRNA levels associated with prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Comprehensive miRNA expression analysis in peripheral blood can diagnose liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Role of pancreatic cancer-derived exosomes in salivary biomarker development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Circulating microRNAs as stable blood-based markers for cancer detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Survivin is released from cancer cells via exosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Exosomal tumor-suppressive microRNAs as novel cancer therapy: "exocure" is another choice for cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Ceramide triggers budding of exosome vesicles into multivesicular endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Rab27a and Rab27b control different steps of the exosome secretion pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Proteomics of colorectal cancer: overview of discovery studies and identification of commonly identified cancer-associated proteins and candidate CRC serum markers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Proteomics analysis of bladder cancer exosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Breast cancer exosome-like microvesicles and salivary gland cells interplay alters salivary gland cell-derived exosome-like microvesicles in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Selective release of microRNA species from normal and malignant mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Extracellular vesicles: exosomes, microvesicles, and friends

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Comparative marker analysis of extracellular vesicles in different human cancer types

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300389

21 January 2018

Identifiers

DOI

10.1002/PMIC.201300389

1 reference

30 August 2017

1 reference