(Q38171958)

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The potential role of kynurenines in Alzheimer's disease: pathomechanism and therapeutic possibilities by influencing the glutamate receptors.

scientific article published on 18 December 2013

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24346138%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

The potential role of kynurenines in Alzheimer's disease: pathomechanism and therapeutic possibilities by influencing the glutamate receptors (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24346138%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Alzheimer's disease

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3 March 2020

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József Toldi

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3 March 2020

Zsófia Majláth

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Zsófia Majláth

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3 March 2020

publication date

18 December 2013

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3 March 2020

Journal of Neural Transmission

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3 March 2020

121

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3 March 2020

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3 March 2020

881-889

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3 March 2020

https://scigraph.springernature.com/pub.10.1007/s00702-013-1135-5

0 references

Kynurenine metabolism in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Kynurenine as an Intermediate in the Formation of Nicotinic Acid from Tryptophane by Neurospora

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Protective effect of systemic L-kynurenine and probenecid administration on behavioural and morphological alterations induced by toxic soluble amyloid beta (25-35) in rat hippocampus.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

The kynurenine pathway and inflammation in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Quinolinic acid effects on amino acid release from the rat cerebral cortex in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Altered kynurenine metabolism correlates with infarct volume in stroke

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Alzheimer disease as a vascular disorder: nosological evidence

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Paradox effects of kynurenines on LTP induction in the Wistar rat. An in vivo study.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Cerebral microvascular pathology in aging and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Blood?Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Behavioural studies with a newly developed neuroprotective KYNA-amide.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

A beta 1-42 induces production of quinolinic acid by human macrophages and microglia

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Duration of antihypertensive drug use and risk of dementia: A prospective cohort study

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

pH dependence, substrate specificity and inhibition of human kynurenine aminotransferase I.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Decreased serum and red blood cell kynurenic acid levels in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Endogenous protectant kynurenic acid in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

A diagnostic method for suspected Alzheimer's disease using H(2)15O positron emission tomography perfusion Z score

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Agonistic autoantibodies to the α(1) -adrenergic receptor and the β(2) -adrenergic receptor in Alzheimer's and vascular dementia

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Antibodies to the α1-adrenergic receptor cause vascular impairments in rat brain as demonstrated by magnetic resonance angiography

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Age-specific and sex-specific prevalence and incidence of mild cognitive impairment, dementia, and Alzheimer dementia in blacks and whites: a report from the Einstein Aging Study

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Vascular disease and dementias: paradigm shifts to drive research in new directions

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Decreased expression of kynurenine aminotransferase-I (KAT-I) in the substantia nigra of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Midlife blood pressure and the risk of hippocampal atrophy: the Honolulu Asia Aging Study.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Kynurenines and other novel therapeutic strategies in the treatment of dementia

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Direct evidence that release-stimulating alpha7* nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Oxaloacetate restores the long-term potentiation impaired in rat hippocampus CA1 region by 2-vessel occlusion

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Oxaloacetate decreases the infarct size and attenuates the reduction in evoked responses after photothrombotic focal ischemia in the rat cortex

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Effects of blood glutamate scavenging on cortical evoked potentials

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Role of kynurenines in the central and peripheral nervous systems

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Advances in the early detection of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Kynurenine pathway abnormalities in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Two kynurenine aminotransferases in human brain

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Diabetes mellitus and the risk of dementia: The Rotterdam Study.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Genetic and hormonal regulation of tryptophan kynurenine metabolism: implications for vascular cognitive impairment, major depressive disorder, and aging.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Kynurenic acid has a dual action on AMPA receptor responses.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

The excitotoxin quinolinic acid induces tau phosphorylation in human neurons

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Quinolinic acid is a potent lipid peroxidant in rat brain homogenates

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

The Janus-face kynurenic acid

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Blood pressure and risk of dementia: results from the Rotterdam study and the Gothenburg H-70 Study.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Change in blood pressure and incident dementia: a 32-year prospective study

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Diagnostic patterns of regional atrophy on MRI and regional cerebral blood flow change on SPECT in young onset patients with Alzheimer's disease, frontotemporal dementia and vascular dementia.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Kynurenines in the CNS: recent advances and new questions.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Tryptophan degradation and immune activation in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Increased neopterin production and tryptophan degradation in advanced Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

The Prevalence of Dementia in Europe: A Collaborative Study of 1980–1990 Findings

1 reference

https://api.crossref.org/works/10.1007%2FS00702-013-1135-5

21 January 2018

Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model

1 reference

https://pubmed.ncbi.nlm.nih.gov/24346138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/24346138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sera from patients with type 2 diabetes contain agonistic autoantibodies against G protein-coupled receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24346138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/24346138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24346138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biological effects of some kynurenic acid analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/24346138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of tryptophan in neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/24346138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of hormones and vitamin B6 on urinary excretion of metabolites of the kynurenine pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/24346138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24346138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/24346138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00702-013-1135-5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24346138%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24346138%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

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