(Q38172655)

30 August 2017

P2X3 and P2X2/3 receptor antagonists (English)

1 reference

30 August 2017

Hedvig Bölcskei

1

1 reference

PubMed ID

24354979

30 August 2017

Bence Farkas

series ordinal

2

1 reference

30 August 2017

1 January 2014

1 reference

Pharmaceutical patent analyst

30 August 2017

1 reference

30 August 2017

3

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30 August 2017

1

1 reference

30 August 2017

53-64

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The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart

30 August 2017

1 reference

The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves

21 January 2018

1 reference

Purinergic innervation of the guinea-pig urinary bladder

21 January 2018

1 reference

New structure enlivens interest in P2X receptors.

21 January 2018

1 reference

P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels

21 January 2018

1 reference

Activation and regulation of purinergic P2X receptor channels

21 January 2018

1 reference

P2X receptors as drug targets

21 January 2018

1 reference

Purinergic mechanisms and pain--an update

21 January 2018

1 reference

A P2X purinoceptor expressed by a subset of sensory neurons

21 January 2018

1 reference

P2X3 receptor involvement in pain states

21 January 2018

1 reference

Localization of P2X2 and P2X3 receptors in rat trigeminal ganglion neurons.

21 January 2018

1 reference

In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization

21 January 2018

1 reference

ATP signaling is crucial for communication from taste buds to gustatory nerves

21 January 2018

1 reference

P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP

21 January 2018

1 reference

P2X purinergic receptor ligands: recently patented compounds

21 January 2018

1 reference

P2X receptor antagonists for pain management: examination of binding and physicochemical properties

21 January 2018

1 reference

Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain

21 January 2018

1 reference

The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1 beta, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice

21 January 2018

1 reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

Lead- and drug-like compounds: the rule-of-five revolution

21 January 2018

1 reference

A ‘Rule of Three’ for fragment-based lead discovery?

21 January 2018

1 reference

The suramin analog 4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups.

21 January 2018

1 reference

Molecular physiology of P2X receptors

21 January 2018

1 reference

Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist.

21 January 2018

1 reference

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.

21 January 2018

1 reference

Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice

21 January 2018

1 reference

Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

21 January 2018

1 reference

Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X(2/3) receptor function and exerts an analgesic effect in pain models

21 January 2018

1 reference

Discovery of P2X3 selective antagonists for the treatment of chronic pain

21 January 2018

1 reference

Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain

21 January 2018

1 reference

Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain

21 January 2018

1 reference

Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist

21 January 2018

1 reference

P2X receptor-mediated ATP purinergic signaling in health and disease

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/PPA.13.70

1 reference

30 August 2017

1 reference

PubMed ID

24354979