(Q38182826)

30 August 2017

Regulating excitability of peripheral afferents: emerging ion channel targets (English)

1 reference

30 August 2017

Gerald W Zamponi

2

0 references

author name string

Stephen G Waxman

series ordinal

1

1 reference

PubMed ID

24473263

30 August 2017

language of work or name

English

0 references

publication date

28 January 2014

1 reference

30 August 2017

1 reference

30 August 2017

17

1 reference

30 August 2017

2

1 reference

30 August 2017

153-163

1 reference

https://scigraph.springernature.com/pub.10.1038/nn.3602

30 August 2017

0 references

cites work

Calcium-permeable ion channels in pain signaling

1 reference

21 January 2018

Sodium channels and pain

1 reference

Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons

21 January 2018

1 reference

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

21 January 2018

1 reference

Gain-of-function Nav1.8 mutations in painful neuropathy.

21 January 2018

1 reference

Annexin II light chain regulates sensory neuron-specific sodium channel expression

21 January 2018

1 reference

Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons

21 January 2018

1 reference

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

21 January 2018

1 reference

The Na(V)1.7 sodium channel: from molecule to man.

21 January 2018

1 reference

Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain

21 January 2018

1 reference

Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury.

21 January 2018

1 reference

Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas.

21 January 2018

1 reference

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

21 January 2018

1 reference

Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.

21 January 2018

1 reference

SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

21 January 2018

1 reference

An SCN9A channelopathy causes congenital inability to experience pain

21 January 2018

1 reference

A sodium channel gene SCN9A polymorphism that increases nociceptor excitability

21 January 2018

1 reference

Pain perception is altered by a nucleotide polymorphism in SCN9A

21 January 2018

1 reference

Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker

21 January 2018

1 reference

Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.

21 January 2018

1 reference

A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

21 January 2018

1 reference

Nociceptors are interleukin-1beta sensors

21 January 2018

1 reference

Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons

21 January 2018

1 reference

The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

21 January 2018

1 reference

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

21 January 2018

1 reference

Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8.

21 January 2018

1 reference

NaN/Nav1.9: a sodium channel with unique properties

21 January 2018

1 reference

The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.

21 January 2018

1 reference

Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior

21 January 2018

1 reference

Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury.

21 January 2018

1 reference

Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats

21 January 2018

1 reference

Virus-mediated shRNA knockdown of Na(v)1.3 in rat dorsal root ganglion attenuates nerve injury-induced neuropathic pain

21 January 2018

1 reference

Loss-of-function mutations in sodium channel Nav1.7 cause anosmia.

21 January 2018

1 reference

Potassium channels: a review of broadening therapeutic possibilities for neurological diseases

21 January 2018

1 reference

The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia

21 January 2018

1 reference

Distinct potassium channels on pain-sensing neurons

21 January 2018

1 reference

Sensory neuron downregulation of the Kv9.1 potassium channel subunit mediates neuropathic pain following nerve injury.

21 January 2018

1 reference

Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model

21 January 2018

1 reference

A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons

21 January 2018

1 reference

Kv1.1 channels act as mechanical brake in the senses of touch and pain

21 January 2018

1 reference

Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats

21 January 2018

1 reference

Chronic pain as a manifestation of potassium channel-complex autoimmunity

21 January 2018

1 reference

The neuronal background K2P channels: focus on TREK1

21 January 2018

1 reference

Leak K⁺ channel mRNAs in dorsal root ganglia: relation to inflammation and spontaneous pain behaviour

21 January 2018

1 reference

TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons.

21 January 2018

1 reference

TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones.

21 January 2018

1 reference

TRESK channel contribution to nociceptive sensory neurons excitability: modulation by nerve injury.

21 January 2018

1 reference

TREK-1, a K+ channel involved in polymodal pain perception

21 January 2018

1 reference

The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception

21 January 2018

1 reference

Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK

21 January 2018

1 reference

Colitis decreases mechanosensitive K2P channel expression and function in mouse colon sensory neurons

21 January 2018

1 reference

Pain-associated signals, acidosis and lysophosphatidic acid, modulate the neuronal K(2P)2.1 channel

21 January 2018

1 reference

Intrathecal TRESK gene recombinant adenovirus attenuates spared nerve injury-induced neuropathic pain in rats

21 January 2018

1 reference

A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels

21 January 2018

1 reference

Ca2+-activated K+ channels: from protein complexes to function

21 January 2018

1 reference

The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system

21 January 2018

1 reference

Characterization of voltage-and Ca2+-activated K+ channels in rat dorsal root ganglion neurons.

21 January 2018

1 reference

A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes.

21 January 2018

1 reference

BKCa currents are enriched in a subpopulation of adult rat cutaneous nociceptive dorsal root ganglion neurons

21 January 2018

1 reference

Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors

21 January 2018

2 references

21 January 2018

12 December 2020

Plasticity and emerging role of BKCa channels in nociceptive control in neuropathic pain

1 reference

Nerve injury increases brain-derived neurotrophic factor levels to suppress BK channel activity in primary sensory neurons

21 January 2018

1 reference

For K+ channels, Na+ is the new Ca2+.

21 January 2018

1 reference

Slack and Slick KNa channels are required for the depolarizing afterpotential of acutely isolated, medium diameter rat dorsal root ganglion neurons.

21 January 2018

1 reference

PKA-induced internalization of slack KNa channels produces dorsal root ganglion neuron hyperexcitability

21 January 2018

1 reference

mTORC2 controls actin polymerization required for consolidation of long-term memory.

21 January 2018

1 reference

Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception.

21 January 2018

1 reference

Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons

21 January 2018

1 reference

State-dependent properties of a new T-type calcium channel blocker enhance Ca(V)3.2 selectivity and support analgesic effects

21 January 2018

1 reference

A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain.

21 January 2018

1 reference

A role for T-type Ca2+ channels in mechanosensation

21 January 2018

1 reference

Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse

21 January 2018

1 reference

Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons

21 January 2018

1 reference

A Ca(v)3.2/syntaxin-1A signaling complex controls T-type channel activity and low-threshold exocytosis

21 January 2018

1 reference

T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures

21 January 2018

1 reference

Calcium-activated chloride channels.

21 January 2018

1 reference

Axotomy-induced expression of calcium-activated chloride current in subpopulations of mouse dorsal root ganglion neurons

21 January 2018

1 reference

The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels

21 January 2018

1 reference

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

21 January 2018

1 reference

HCN channels: function and clinical implications

21 January 2018

1 reference

Expression of hyperpolarization-activated cyclic nucleotide-gated cation channels in rat dorsal root ganglion neurons innervating urinary bladder.

21 January 2018

1 reference

HCN1 and HCN2 in Rat DRG neurons: levels in nociceptors and non-nociceptors, NT3-dependence and influence of CFA-induced skin inflammation on HCN2 and NT3 expression

21 January 2018

1 reference

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors.

21 January 2018

1 reference

HCN pacemaker channels and pain: a drug discovery perspective

21 January 2018

1 reference

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura

21 January 2018

1 reference

Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes

21 January 2018

1 reference

Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy.

21 January 2018

1 reference

Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex

21 January 2018

1 reference

Small nerve fibres, small hands and small feet: a new syndrome of pain, dysautonomia and acromesomelia in a kindred with a novel NaV1.7 mutation.

21 January 2018

1 reference

HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain

21 January 2018

1 reference

Chronic inflammatory pain is associated with increased excitability and hyperpolarization-activated current (Ih) in C- but not Aδ-nociceptors

21 January 2018

1 reference

12 December 2020

Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor

1 reference

12 December 2020

The reversal potential of Ca(2+)-activated Cl(-) currents indicates that chick sensory neurons accumulate intracellular Cl(-)

1 reference

12 December 2020

Plasticity of hyperpolarization-activated and cyclic nucleotid-gated cation channel subunit 2 expression in the spinal dorsal horn in inflammatory pain

1 reference

12 December 2020

Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons.

1 reference

12 December 2020

Changes of sodium channel expression in experimental painful diabetic neuropathy

1 reference

12 December 2020

Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy

1 reference

12 December 2020

Involvement of hyperpolarization-activated, cyclic nucleotide-gated cation channels in dorsal root ganglion in neuropathic pain

1 reference

12 December 2020

TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing

1 reference

12 December 2020

Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons

1 reference

12 December 2020

Nav1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NN.3602

1 reference

30 August 2017

1 reference

PubMed ID

24473263