(Q38199518)

30 August 2017

title

Advances in targeted delivery of small interfering RNA using simple bioconjugates (English)

1 reference

30 August 2017

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24669756%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Lars Henning Engelholm

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24669756%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Niels Behrendt

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24669756%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Christoffer Nielsen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24669756%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Kristine Rothaus Sørensen

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24669756%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

language of work or name

English

0 references

publication date

26 March 2014

1 reference

Expert Opinion on Drug Delivery

30 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24669756%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24669756%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24669756%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

791-822

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24669756%20AND%20SRC:MED&resulttype=core&format=json

Molecular mechanisms of RNA interference

11 June 2020

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

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RNA interference is mediated by 21- and 22-nucleotide RNAs

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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RNA interference in adult mice.

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Receptors, endocytosis, and trafficking: the biological basis of targeted delivery of antisense and siRNA oligonucleotides

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Subcellular targeting strategies for drug design and delivery

21 January 2018

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An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

21 January 2018

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Biodistribution of phosphodiester and phosphorothioate siRNA.

21 January 2018

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The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.

21 January 2018

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Chemical modification of siRNAs for in vivo use.

21 January 2018

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Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering

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Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

21 January 2018

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Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

21 January 2018

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UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability.

21 January 2018

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Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

21 January 2018

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RNA interference in mammalian cells by chemically-modified RNA.

21 January 2018

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Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

21 January 2018

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RNA interference using boranophosphate siRNAs: structure-activity relationships

21 January 2018

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A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides

21 January 2018

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Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.

21 January 2018

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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

21 January 2018

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PEGylation, successful approach to drug delivery

21 January 2018

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Optimized siRNA-PEG conjugates for extended blood circulation and reduced urine excretion in mice

21 January 2018

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Pattern recognition receptors and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Silencing or stimulation? siRNA delivery and the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

The RNA-induced silencing complex: a versatile gene-silencing machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Improved silencing properties using small internally segmented interfering RNAs

21 January 2018

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A highly sensitive method for mapping the 5' termini of mRNAs.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Biodistribution of small interfering RNA at the organ and cellular levels after lipid nanoparticle-mediated delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Tumor targeting based on the effect of enhanced permeability and retention (EPR) and the mechanism of receptor-mediated endocytosis (RME).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Chitosan-based formulations for delivery of DNA and siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Cationic lipid-DNA complexes for non-viral gene therapy: relating supramolecular structures to cellular pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

21 January 2018

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The possible "proton sponge " effect of polyethylenimine (PEI) does not include change in lysosomal pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Endosomal escape pathways for delivery of biologicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Anthrax toxin: receptor binding, internalization, pore formation, and translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

The structure and function of the hemagglutinin membrane glycoprotein of influenza virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Rational design and in vitro and in vivo delivery of Dicer substrate siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Lysosomes and autophagy in cell death control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Physiological functions of thioredoxin and thioredoxin reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Tolerance of RNA interference toward modifications of the 5' antisense phosphate of small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

In vitro selection of RNA molecules that bind specific ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Cell-specific aptamer-mediated targeted drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Therapeutic applications of DNA and RNA aptamers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Specific delivery of therapeutic RNAs to cancer cells via the dimerization mechanism of phi29 motor pRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Aptamer mediated siRNA delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Dual functional BAFF receptor aptamers inhibit ligand-induced proliferation and deliver siRNAs to NHL cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Thermal Stability of siRNA Modulates Aptamer- conjugated siRNA Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

High-density lipoprotein facilitates in vivo delivery of α-tocopherol-conjugated short-interfering RNA to the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Tissue specific delivery of estrone-conjugated siRNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Cell-penetrating peptides: breaking through to the other side

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Phosphorothioate-stimulated uptake of short interfering RNA by human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Transvascular delivery of small interfering RNA to the central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Targeted delivery of siRNA to macrophages for anti-inflammatory treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Targeted Delivery of Small Interfering RNA to Human Dendritic Cells To Suppress Dengue Virus Infection and Associated Proinflammatory Cytokine Production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Vasopressin V2R-targeting peptide carrier mediates siRNA delivery into collecting duct cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Multivalent cyclic RGD conjugates for targeted delivery of small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Insulin receptor substrate 1 knockdown in human MCF7 ER+ breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analogue of insulin-like growth factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Fcgamma receptors as regulators of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Targeted inhibition of HBV gene expression by single-chain antibody mediated small interfering RNA delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

The transferrin receptor and the targeted delivery of therapeutic agents against cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Constructing bioactive peptides with pH-dependent activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Mechanisms of endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Endocytosis at the nanoscale

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Exploiting endocytosis for nanomedicines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Current progress of siRNA/shRNA therapeutics in clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Current prospects for RNA interference-based therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Mipomersen sodium: first global approval

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

Visualizing a Correlation between siRNA Localization, Cellular Uptake, and RNAi in Living Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.2014.896898

10.1517/17425247.2014.896898

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24669756%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference