(Q37571996)

21 August 2017

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title

Therapeutic applications of DNA and RNA aptamers (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6469516&resulttype=core&format=json

14 May 2020

author name string

Kristina W Thiel

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6469516&resulttype=core&format=json

14 May 2020

Paloma H Giangrande

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6469516&resulttype=core&format=json

14 May 2020

publication date

1 September 2009

1 reference

21 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6469516&resulttype=core&format=json

14 May 2020

volume

19

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6469516&resulttype=core&format=json

14 May 2020

issue

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6469516&resulttype=core&format=json

14 May 2020

page(s)

209-222

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6469516&resulttype=core&format=json

Selection and characterization of an RNA decoy for transcription factor NF-kappa B.

14 May 2020

cites work

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12 December 2020

Combinatorial selection of high affinity RNA ligands to live African trypanosomes

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12 December 2020

Potent inhibition of human immunodeficiency virus type 1 (HIV-1) gene expression and virus production by an HIV-2 tat activation-response RNA decoy

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12 December 2020

A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children.

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12 December 2020

RNA aptamers as effective protein antagonists in a multicellular organism

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12 December 2020

Antiproliferative activity of G-rich oligonucleotides correlates with protein binding

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12 December 2020

A novel RNA motif that binds efficiently and specifically to the Ttat protein of HIV and inhibits the trans-activation by Tat of transcription in vitro and in vivo

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12 December 2020

Blocking the initiation of coagulation by RNA aptamers to factor VIIa

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12 December 2020

Systematic evolution of a DNA aptamer binding to rat brain tumor microvessels. selective targeting of endothelial regulatory protein pigpen

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12 December 2020

Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy

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12 December 2020

Tenascin-C aptamers are generated using tumor cells and purified protein

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12 December 2020

Generation of species cross-reactive aptamers using "toggle" SELEX.

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12 December 2020

Selection of RNA aptamers to the Alzheimer's disease amyloid peptide

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12 December 2020

Antiproliferative activity of G-quartet-forming oligonucleotides with backbone and sugar modifications.

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12 December 2020

Oligonucleotide conjugates as potential antisense drugs with improved uptake, biodistribution, targeted delivery, and mechanism of action

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12 December 2020

Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen

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12 December 2020

Prion-protein-specific aptamer reduces PrPSc formation

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12 December 2020

RNA aptamers as reversible antagonists of coagulation factor IXa.

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12 December 2020

A nucleolar TAR decoy inhibitor of HIV-1 replication.

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12 December 2020

Yeast genetic selections to optimize RNA decoys for transcription factor NF-kappa B

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12 December 2020

Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3.

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12 December 2020

Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion.

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12 December 2020

RNA pseudoknots that inhibit human immunodeficiency virus type 1 reverse transcriptase

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12 December 2020

Spiegelmers: Biostable Aptamers

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12 December 2020

Neutralization of Infectivity of Diverse R5 Clinical Isolates of Human Immunodeficiency Virus Type 1 by gp120-Binding 2′F-RNA Aptamers

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12 December 2020

Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity

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12 December 2020

A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment

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12 December 2020

In vitro evolution of functional DNA using capillary electrophoresis

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12 December 2020

Structural determinants of conformationally selective, prion-binding aptamers.

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12 December 2020

Photoaptamer arrays applied to multiplexed proteomic analysis.

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12 December 2020

Combinatorial selection and edited combinatorial selection of phosphorothioate aptamers targeting human nuclear factor-kappaB RelA/p50 and RelA/RelA

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12 December 2020

Aptamer-based sensor arrays for the detection and quantitation of proteins.

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12 December 2020

Evolution of a T7 RNA polymerase variant that transcribes 2'-O-methyl RNA.

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12 December 2020

Overexpression of RRE-derived sequences inhibits HIV-1 replication in CEM cells

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12 December 2020

Antidote-mediated control of an anticoagulant aptamer in vivo

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12 December 2020

Application of locked nucleic acids to improve aptamer in vivo stability and targeting function

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12 December 2020

Toxicology of antisense therapeutics

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12 December 2020

Pharmacokinetics and biodistribution of novel aptamer compositions

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12 December 2020

Direct in vitro selection of a 2'-O-methyl aptamer to VEGF.

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12 December 2020

Nonequilibrium capillary electrophoresis of equilibrium mixtures: a universal tool for development of aptamers.

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12 December 2020

Development of an automated in vitro selection protocol to obtain RNA-based aptamers: identification of a biostable substance P antagonist

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12 December 2020

Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase

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12 December 2020

A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema

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12 December 2020

Production and processing of aptamer microarrays

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12 December 2020

Conjugation to polyethylene glycol polymer promotes aptamer biodistribution to healthy and inflamed tissues.

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12 December 2020

The PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) trial: study rationale, design, and baseline patient characteristics.

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12 December 2020

An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction

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12 December 2020

Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial

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12 December 2020

Intraocular injection of an aptamer that binds PDGF-B: a potential treatment for proliferative retinopathies

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12 December 2020

Bimodal loop-loop interactions increase the affinity of RNA aptamers for HIV-1 RNA structures

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12 December 2020

Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

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12 December 2020

Selection of RNA aptamers against recombinant transforming growth factor-beta type III receptor displayed on cell surface

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12 December 2020

Tumor targeting by an aptamer

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12 December 2020

Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo

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12 December 2020

Results of PREVENT III: a multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery

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12 December 2020

Aptamer mediated siRNA delivery

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12 December 2020

Aptamer:toxin conjugates that specifically target prostate tumor cells

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12 December 2020

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

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12 December 2020

RNA aptamers selectively modulate protein recruitment to the cytoplasmic domain of beta-secretase BACE1 in vitro

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12 December 2020

AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin.

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12 December 2020

In vitro selection of RNA molecules that bind specific ligands

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12 December 2020

Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery

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12 December 2020

An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform

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12 December 2020

First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity

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12 December 2020

Comparison of different strategies to select aptamers against a transmembrane protein target.

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12 December 2020

Discovery and development of anticancer aptamers

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12 December 2020

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

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12 December 2020

Aptamer from whole-bacterium SELEX as new therapeutic reagent against virulent Mycobacterium tuberculosis

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12 December 2020

Aptamers evolved from cultured cancer cells reveal molecular differences of cancer cells in patient samples.

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12 December 2020

Selection of aptamers for molecular recognition and characterization of cancer cells

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12 December 2020

Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia.

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12 December 2020

Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102

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12 December 2020

Antidote-controlled platelet inhibition targeting von Willebrand factor with aptamers

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12 December 2020

Production and Characterization of RNA Aptamers Specific for Amyloid Fibril Epitopes

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12 December 2020

Multidomain targeting generates a high-affinity thrombin-inhibiting bivalent aptamer

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12 December 2020

First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers

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12 December 2020

Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.

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12 December 2020

Potent inhibition of human influenza H5N1 virus by oligonucleotides derived by SELEX.

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12 December 2020

Complex target SELEX.

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12 December 2020

Post-SELEX chemical optimization of a trypanosome-specific RNA aptamer

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12 December 2020

A randomized, repeat-dose, pharmacodynamic and safety study of an antidote-controlled factor IXa inhibitor

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12 December 2020

The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells

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12 December 2020

Molecular assembly for high-performance bivalent nucleic acid inhibitor

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12 December 2020

Selection and characterization of anti-NF-kappaB p65 RNA aptamers

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12 December 2020

Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy

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12 December 2020

Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease

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12 December 2020

Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

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12 December 2020

Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer

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12 December 2020

SELEX with modified nucleotides

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12 December 2020

Aptamer-based endocytosis of a lysosomal enzyme

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12 December 2020

Distribution and bioactivity of the Ret-specific D4 aptamer in three-dimensional collagen gel cultures.

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12 December 2020

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase

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12 December 2020

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles

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12 December 2020

Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2.

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12 December 2020

Chemical modification of siRNAs for in vivo use.

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12 December 2020

Phototoxic aptamers selectively enter and kill epithelial cancer cells

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12 December 2020

Bivalent ligands with long nanometer-scale flexible linkers

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12 December 2020

Differential regulation of protein subdomain activity with caged bivalent ligands.

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12 December 2020

Micromagnetic selection of aptamers in microfluidic channels

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12 December 2020

Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells

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12 December 2020

Technical and biological issues relevant to cell typing with aptamers

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12 December 2020

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

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12 December 2020

Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation

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12 December 2020

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

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12 December 2020

Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication

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12 December 2020

High-affinity ssDNA inhibitors of the reverse transcriptase of type 1 human immunodeficiency virus

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12 December 2020

Inhibitory DNA ligands to platelet-derived growth factor B-chain

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12 December 2020

Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function

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12 December 2020

Bent pseudoknots and novel RNA inhibitors of type 1 human immunodeficiency virus (HIV-1) reverse transcriptase

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12 December 2020

Mechanism of ribose 2'-group discrimination by an RNA polymerase

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12 December 2020

RNA aptamers specifically interact with the prion protein PrP.

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12 December 2020

Oligonucleotide analogues: an overview

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12 December 2020

2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain

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12 December 2020

Liposome-anchored vascular endothelial growth factor aptamers

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12 December 2020

Automated RNA selection.

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12 December 2020

Identifiers

DOI

10.1089/OLI.2009.0199

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6469516&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6469516&resulttype=core&format=json

14 May 2020

1 reference