(Q40014125)

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Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.

scientific article published on 11 February 2008

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scholarly article

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2 January 2020

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect (English)

1 reference

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2 January 2020

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2 January 2020

author name string

Kumiko Ui-Tei

1

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2 January 2020

Shuhei Zenno

3

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2 January 2020

Kenji Nishi

4

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2 January 2020

Kenji Yamato

5

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2 January 2020

Fumitaka Takahashi

6

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2 January 2020

Aya Juni

7

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2 January 2020

Kaoru Saigo

8

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2 January 2020

publication date

11 February 2008

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2 January 2020

Nucleic Acids Research

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2 January 2020

36

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2 January 2020

2136-2151

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2 January 2020

7

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2 January 2020

MicroRNA targeting specificity in mammals: determinants beyond seed pairing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Illuminating the silence: understanding the structure and function of small RNAs

1 reference

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22 September 2017

Guidelines for the selection of effective short-interfering RNA sequences for functional genomics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

The role of PACT in the RNA silencing pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

RNAi: the nuts and bolts of the RISC machine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Dissecting RNA-interference pathway with small molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Perspective: machines for RNAi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

A protein sensor for siRNA asymmetry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Argonaute2 is the catalytic engine of mammalian RNAi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Crystal structure of Argonaute and its implications for RISC slicer activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

MicroRNA-directed cleavage of HOXB8 mRNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Rational siRNA design for RNA interference

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Prediction of mammalian microRNA targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Identification of Drosophila MicroRNA targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Functional siRNAs and miRNAs Exhibit Strand Bias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Asymmetry in the assembly of the RNAi enzyme complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Expression profiling reveals off-target gene regulation by RNAi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

siRNAs can function as miRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

RNA interference

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

ATP requirements and small interfering RNA structure in the RNA interference pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

RNA interference is mediated by 21- and 22-nucleotide RNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Psx homeobox gene is X-linked and specifically expressed in trophoblast cells of mouse placenta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

PACT, a protein activator of the interferon-induced protein kinase, PKR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Stability of ribonucleic acid double-stranded helices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Predicting DNA duplex stability from the base sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Improved free-energy parameters for predictions of RNA duplex stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

22 September 2017

Determinants of targeting by endogenous and exogenous microRNAs and siRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

17 June 2018

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

17 June 2018

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

17 June 2018

siRNA function in RNAi: a chemical modification analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

17 June 2018

RNAi: RISC gets loaded.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

20 August 2018

Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

20 August 2018

Comparison of different melting temperature calculation methods for short DNA sequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

20 August 2018

An algorithm for selection of functional siRNA sequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

20 August 2018

Robust estimators for expression analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2367719

20 August 2018

RNA interference (RNA(i)) induction with various types of synthetic oligonucleotide duplexes in cultured human cells.

1 reference

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20 August 2018

Noise amidst the silence: off-target effects of siRNAs?

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKN042

21 January 2018

Thermodynamic parameters to predict stability of RNA/DNA hybrid duplexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18267968

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NAR/GKN042

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18267968%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18267968%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

Europe PubMed Central

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2 January 2020

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