(Q38212170)

31 August 2017

Liver X receptors in lipid metabolism: opportunities for drug discovery (English)

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31 August 2017

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2

Peter Tontonoz

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31 August 2017

Cynthia Hong

1

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31 August 2017

16 May 2014

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Nature Reviews Drug Discovery

31 August 2017

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31 August 2017

13

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31 August 2017

6

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31 August 2017

433-444

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https://scigraph.springernature.com/pub.10.1038/nrd4280

31 August 2017

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cites work

A receptor-mediated pathway for cholesterol homeostasis

1 reference

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

31 March 2020

1 reference

The LXRs: a new class of oxysterol receptors

31 March 2020

1 reference

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

31 March 2020

1 reference

Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines

31 March 2020

1 reference

Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.

31 March 2020

1 reference

NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols

31 March 2020

1 reference

27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells

31 March 2020

1 reference

Crystal structure of the heterodimeric complex of LXR and RXR ligand-binding domains in a fully agonistic conformation

31 March 2020

1 reference

Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression

31 March 2020

1 reference

Liver X receptors interact with corepressors to regulate gene expression

31 March 2020

1 reference

Role of p160 coactivator complex in the activation of liver X receptor

31 March 2020

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Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors

31 March 2020

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Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages

31 March 2020

1 reference

Molecular determinants of the interactions between LXR/RXR heterodimers and TRAP220.

31 March 2020

1 reference

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

31 March 2020

1 reference

Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites

31 March 2020

1 reference

Differential nuclear receptor signalling from DR4-type response elements

31 March 2020

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Action mechanisms of Liver X Receptors.

31 March 2020

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Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity

31 March 2020

1 reference

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

31 March 2020

1 reference

The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions

31 March 2020

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LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

31 March 2020

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Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

31 March 2020

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Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

31 March 2020

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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

31 March 2020

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Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE

31 March 2020

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Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

31 March 2020

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Synthetic LXR ligand inhibits the development of atherosclerosis in mice

31 March 2020

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Identification of macrophage liver X receptors as inhibitors of atherosclerosis

31 March 2020

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Regulation and Mechanisms of ATP-Binding Cassette Transporter A1-Mediated Cellular Cholesterol Efflux

31 March 2020

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ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter

31 March 2020

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Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

31 March 2020

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The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

31 March 2020

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Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

31 March 2020

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Intestinal ABCA1 directly contributes to HDL biogenesis in vivo

31 March 2020

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Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels.

31 March 2020

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Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target

31 March 2020

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Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

31 March 2020

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Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target

31 March 2020

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Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.

31 March 2020

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Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element

31 March 2020

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LXRalpha regulates human CETP expression in vitro and in transgenic mice

31 March 2020

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LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice

31 March 2020

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Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

31 March 2020

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Acute effects of intravenous infusion of ApoA1/phosphatidylcholine discs on plasma lipoproteins in humans

31 March 2020

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Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo

31 March 2020

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The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential

31 March 2020

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Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

31 March 2020

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Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation

31 March 2020

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Suppression of chronic damage in renal allografts by Liver X receptor (LXR) activation relevant contribution of macrophage LXRα.

31 March 2020

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LXR, a nuclear receptor that defines a distinct retinoid response pathway

31 March 2020

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Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance

31 March 2020

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Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia

31 March 2020

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Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.

31 March 2020

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Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient mice

31 March 2020

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Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator

31 March 2020

1 reference

Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice

31 March 2020

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Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.

31 March 2020

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The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages

31 March 2020

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Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism

31 March 2020

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Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages

31 March 2020

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LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression

31 March 2020

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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

31 March 2020

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LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor

31 March 2020

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Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

31 March 2020

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Discovery of a new small-molecule inhibitor of p53-MDM2 interaction using a yeast-based approach

31 March 2020

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Development of noncytotoxic PLGA nanoparticles to improve the effect of a new inhibitor of p53-MDM2 interaction

31 March 2020

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Distinct functional domains contribute to degradation of the low density lipoprotein receptor (LDLR) by the E3 ubiquitin ligase inducible Degrader of the LDLR (IDOL).

31 March 2020

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FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors

31 March 2020

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The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

31 March 2020

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IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor

31 March 2020

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The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

31 March 2020

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The inflammatory response in acyl-CoA oxidase 1 deficiency (pseudoneonatal adrenoleukodystrophy)

31 March 2020

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Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists

31 March 2020

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The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans

31 March 2020

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Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.

31 March 2020

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Biological, clinical and population relevance of 95 loci for blood lipids

31 March 2020

1 reference

Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein.

31 March 2020

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Biliary sterol secretion is not required for macrophage reverse cholesterol transport

31 March 2020

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Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss

31 March 2020

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Biliary and nonbiliary contributions to reverse cholesterol transport

31 March 2020

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Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

31 March 2020

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Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

31 March 2020

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Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis

31 March 2020

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Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice.

31 March 2020

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Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol

31 March 2020

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

31 March 2020

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Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1.

31 March 2020

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Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I

31 March 2020

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Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8.

31 March 2020

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Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

31 March 2020

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Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

31 March 2020

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Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis

31 March 2020

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Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo

31 March 2020

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Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis

31 March 2020

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Phosphomevalonate kinase is a cytosolic protein in humans

31 March 2020

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Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome

31 March 2020

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Genetic classification and mutational spectrum of more than 600 patients with a Zellweger syndrome spectrum disorder

31 March 2020

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Cholesterol: its regulation and role in central nervous system disorders

31 March 2020

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Succinyl-CoA ligase deficiency: a mitochondrial hepatoencephalomyopathy

31 March 2020

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Biochemistry of mammalian peroxisomes revisited

31 March 2020

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Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

31 March 2020

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ApoE promotes the proteolytic degradation of Abeta

31 March 2020

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Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke.

31 March 2020

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Treatment with LXR agonists after focal cerebral ischemia prevents brain damage

31 March 2020

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Expression of liver X receptor beta is essential for formation of superficial cortical layers and migration of later-born neurons

31 March 2020

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Liver X receptor and retinoid X receptor agonists inhibit inflammatory responses of microglia and astrocytes

31 March 2020

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Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration

31 March 2020

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

31 March 2020

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Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease.

31 March 2020

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Comprehensive search for Alzheimer disease susceptibility loci in the APOE region

31 March 2020

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Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels

31 March 2020

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The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.

31 March 2020

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24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.

31 March 2020

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Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

31 March 2020

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Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice

31 March 2020

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Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

31 March 2020

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22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion

31 March 2020

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The role of ABCA1 gene sequence variants on risk of Alzheimer's disease.

31 March 2020

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The selective Alzheimer's disease indicator-1 gene (Seladin-1/DHCR24) is a liver X receptor target gene

31 March 2020

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The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress

31 March 2020

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Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis

31 March 2020

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Role of LXRs in control of lipogenesis

31 March 2020

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T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice

31 March 2020

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LXRβ activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile.

31 March 2020

1 reference

X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch

31 March 2020

1 reference

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

31 March 2020

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Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator

31 March 2020

1 reference

Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist

31 March 2020

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A liver-selective LXR inverse agonist that suppresses hepatic steatosis

31 March 2020

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Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice.

31 March 2020

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Autoregulation of the human liver X receptor alpha promoter

31 March 2020

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The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.

31 March 2020

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ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

31 March 2020

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Treatment of cutaneous T-cell lymphoma with retinoids

31 March 2020

1 reference

Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants.

31 March 2020

1 reference

LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse

31 March 2020

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Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice

31 March 2020

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Synthetic low and high fat diets for the study of atherosclerosis in the mouse

31 March 2020

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12 December 2020

Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice

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12 December 2020

The removal of cholesterol from Landschütz ascites cells by high-density apolipoprotein.

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12 December 2020

Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet

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12 December 2020

Regulation of adrenal scavenger receptor-BI expression by ACTH and cellular cholesterol pools

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12 December 2020

Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I

1 reference

12 December 2020

Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice

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12 December 2020

Subcellular localization and physiological role of alpha-methylacyl-CoA racemase

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12 December 2020

24(S),25-Epoxycholesterol. Evidence consistent with a role in the regulation of hepatic cholesterogenesis

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12 December 2020

Plasma cholesteryl ester transfer protein

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12 December 2020

Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage

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12 December 2020

Identifiers

DOI

10.1038/NRD4280

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31 August 2017

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PubMed ID

24833295