(Q38220292)

31 August 2017

title

MITA/STING: a central and multifaceted mediator in innate immune response (English)

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31 August 2017

3

Yan-Yi Wang

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31 August 2017

Yong Ran

1

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31 August 2017

Hong-Bing Shu

series ordinal

2

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31 August 2017

publication date

20 May 2014

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Cytokine and Growth Factor Reviews

31 August 2017

published in

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31 August 2017

volume

25

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31 August 2017

issue

6

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31 August 2017

page(s)

631-639

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MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP.

31 August 2017

cites work

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12 December 2020

A Toll-like receptor recognizes bacterial DNA

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12 December 2020

DENV inhibits type I IFN production in infected cells by cleaving human STING

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12 December 2020

STING and the innate immune response to nucleic acids in the cytosol

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12 December 2020

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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12 December 2020

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

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12 December 2020

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

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12 December 2020

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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12 December 2020

Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity

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12 December 2020

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

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12 December 2020

Both STING and MAVS fish orthologs contribute to the induction of interferon mediated by RIG-I

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12 December 2020

A diverse range of gene products are effectors of the type I interferon antiviral response

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12 December 2020

STING-dependent cytosolic DNA sensing pathways

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12 December 2020

Dengue virus targets the adaptor protein MITA to subvert host innate immunity

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12 December 2020

Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis

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12 December 2020

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

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12 December 2020

IFI16 is an innate immune sensor for intracellular DNA

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12 December 2020

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.

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12 December 2020

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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12 December 2020

VISA is an adapter protein required for virus-triggered IFN-beta signaling

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12 December 2020

Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum

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12 December 2020

Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING.

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12 December 2020

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

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12 December 2020

RNA recognition and signal transduction by RIG-I-like receptors

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12 December 2020

Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.

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12 December 2020

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

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12 December 2020

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

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12 December 2020

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

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12 December 2020

Immune sensing of DNA

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12 December 2020

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

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12 December 2020

Cloning and functional characterization of rat stimulator of interferon genes (STING) regulated by miR-24.

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12 December 2020

Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7.

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12 December 2020

STING mediates neuronal innate immune response following Japanese encephalitis virus infection

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12 December 2020

NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING

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12 December 2020

Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome

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12 December 2020

Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

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12 December 2020

Activation of STAT6 by STING is critical for antiviral innate immunity

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12 December 2020

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

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12 December 2020

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

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12 December 2020

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA

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12 December 2020

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

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12 December 2020

Cyclic di-GMP sensing via the innate immune signaling protein STING

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12 December 2020

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

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12 December 2020

c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response

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12 December 2020

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

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12 December 2020

The structural basis for the sensing and binding of cyclic di-GMP by STING

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12 December 2020

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

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12 December 2020

TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

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12 December 2020

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

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12 December 2020

Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway

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12 December 2020

MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infection

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12 December 2020

The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.

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12 December 2020

Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling

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12 December 2020

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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12 December 2020

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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12 December 2020

The STING in the tail for cytosolic DNA-dependent activation of IRF3.

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12 December 2020

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

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12 December 2020

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

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12 December 2020

Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade

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12 December 2020

Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

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12 December 2020

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

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12 December 2020

An alternative splicing isoform of MITA antagonizes MITA-mediated induction of type I IFNs

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12 December 2020

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

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12 December 2020

STING recognition of cytoplasmic DNA instigates cellular defense

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12 December 2020

STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway

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12 December 2020

STING manifests self DNA-dependent inflammatory disease

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12 December 2020

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

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12 December 2020

LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection

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12 December 2020

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides

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12 December 2020

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

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12 December 2020

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

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12 December 2020

Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity

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12 December 2020

Ubiquitylation in innate and adaptive immunity.

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12 December 2020

STING is a direct innate immune sensor of cyclic di-GMP

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12 December 2020

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

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12 December 2020

The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

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12 December 2020

Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling

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12 December 2020

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

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12 December 2020

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

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12 December 2020

Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation

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12 December 2020

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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12 December 2020

10.1016/J.CYTOGFR.2014.05.003

Identifiers

DOI

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31 August 2017

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