(Q38229078)

31 August 2017

mTOR signaling in T cell immunity and autoimmunity (English)

1 reference

31 August 2017

Yu Liu

1

1 reference

31 August 2017

Da-tong Zhang

series ordinal

2

1 reference

31 August 2017

Xin-guang Liu

series ordinal

3

1 reference

31 August 2017

14 July 2014

1 reference

International Reviews of Immunology

31 August 2017

1 reference

31 August 2017

34

1 reference

31 August 2017

1

1 reference

31 August 2017

50-66

1 reference

31 August 2017

TOR in the immune system

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

mTOR, linking metabolism and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Molecular organization of target of rapamycin complex 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Structure of the human mTOR complex I and its implications for rapamycin inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

21 January 2018

Expanding mTOR signaling

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Role of S6K1 in regulation of SREBP1c expression in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

DAP1, a novel substrate of mTOR, negatively regulates autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Regulation of TFEB and V-ATPases by mTORC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

TFEB links autophagy to lysosomal biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Differentiation of effector CD4 T cell populations (*)

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Plasticity of CD4+ T cell lineage differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Origins of CD4(+) effector and central memory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Autophagy is essential for mitochondrial clearance in mature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

A critical role for the autophagy gene Atg5 in T cell survival and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

The regulation of Foxp3 expression in regulatory CD4(+)CD25(+)T cells: multiple pathways on the road

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Tr1 cells: from discovery to their clinical application.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

mTOR, metabolism, and the regulation of T-cell differentiation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Regulatory T cells in obesity: the leptin connection.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

CD8+ T-cell memory in tumor immunology and immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Effector and memory CTL differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Memory CD8 T-cell differentiation during viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Prevention of murine lupus disease in (NZBxNZW)F1 mice by sirolimus treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Rapamycin prevents and breaks the anti-CD3-induced tolerance in NOD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Current therapy for autoimmune hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Use of sirolimus (rapamycin) to treat refractory Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Use of sirolimus in IPEX and IPEX-like children

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

mTOR signaling in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Foxp3+ T cells inhibit antitumor immune memory modulated by mTOR inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

Mammalian target of rapamycin: biological function and target for novel anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2014.933957

10.3109/08830185.2014.933957

21 January 2018

Identifiers

DOI

1 reference

release_54q6quj3lrbajcz3gpuetkdpae

31 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/54q6quj3lrbajcz3gpuetkdpae

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference