(Q38235876)

31 August 2017

title

Semaphorins and plexins as therapeutic targets (English)

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31 August 2017

Stefan Offermanns

2

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author name string

Thomas Worzfeld

series ordinal

1

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31 August 2017

publication date

1 August 2014

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Nature Reviews Drug Discovery

31 August 2017

published in

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31 August 2017

volume

13

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31 August 2017

issue

8

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31 August 2017

page(s)

603-621

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Unified nomenclature for the semaphorins/collapsins. Semaphorin Nomenclature Committee

31 August 2017

cites work

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Semaphorin signaling in the immune system

31 March 2020

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Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates

31 March 2020

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Getting neural circuits into shape with semaphorins

31 March 2020

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The role of semaphorins and their receptors in vascular development and cancer.

31 March 2020

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Semaphorins in angiogenesis and tumor progression

31 March 2020

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Immunological functions of the neuropilins and plexins as receptors for semaphorins

31 March 2020

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Semaphorin signaling in cancer cells and in cells of the tumor microenvironment--two sides of a coin

31 March 2020

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Emerging role of semaphorins as major regulatory signals and potential therapeutic targets in cancer.

31 March 2020

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Semaphorins in bone development, homeostasis, and disease

31 March 2020

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Bone cell communication factors and Semaphorins

31 March 2020

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Semaphorin function in neural plasticity and disease.

31 March 2020

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Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer

31 March 2020

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Diverse roles for semaphorin-plexin signaling in the immune system

31 March 2020

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Immune plexins and semaphorins: old proteins, new immune functions

31 March 2020

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Structural insights into semaphorins and their receptors

31 March 2020

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Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions

31 March 2020

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Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1

31 March 2020

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Structural basis for semaphorin signalling through the plexin receptor

31 March 2020

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Structural basis of semaphorin-plexin signalling

31 March 2020

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More than nervous: the emerging roles of plexins

31 March 2020

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Class 3 semaphorins as a therapeutic target

31 March 2020

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Biology and function of neuroimmune semaphorins 4A and 4D

31 March 2020

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31 March 2020

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The chemorepulsive activity of the axonal guidance signal semaphorin D requires dimerization

31 March 2020

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Collapsin-1 covalently dimerizes, and dimerization is necessary for collapsing activity

31 March 2020

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The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D

31 March 2020

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Crucial role of Plexin C1 for pulmonary inflammation and survival during lung injury.

31 March 2020

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Semaphorin signaling: progress made and promises ahead.

31 March 2020

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Semaphorin regulation of cellular morphology

31 March 2020

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Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex

31 March 2020

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Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A.

31 March 2020

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Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

31 March 2020

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The semaphorin 4D receptor controls invasive growth by coupling with Met

31 March 2020

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Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

31 March 2020

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Semaphorin 7A promotes axon outgrowth through integrins and MAPKs

31 March 2020

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Semaphorins and their receptors in immune cell interactions.

31 March 2020

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The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras

31 March 2020

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Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology.

31 March 2020

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Regulating Rap small G-proteins in time and space

31 March 2020

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Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology

31 March 2020

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Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors

31 March 2020

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The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG

31 March 2020

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Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF

31 March 2020

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Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex

31 March 2020

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Structure and function of the intracellular region of the plexin-b1 transmembrane receptor

31 March 2020

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Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration

31 March 2020

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Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin

31 March 2020

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Class 3 semaphorins: physiological vascular normalizing agents for anti-cancer therapy

31 March 2020

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Semaphorin 3E suppresses tumor cell death triggered by the plexin D1 dependence receptor in metastatic breast cancers

31 March 2020

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Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer.

31 March 2020

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Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies.

31 March 2020

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Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis

31 March 2020

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Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform

31 March 2020

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Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras.

31 March 2020

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Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells

31 March 2020

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Semaphorin-3D and semaphorin-3E inhibit the development of tumors from glioblastoma cells implanted in the cortex of the brain

31 March 2020

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Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression.

31 March 2020

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Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function

31 March 2020

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Semaphorin 3A suppresses tumor growth and metastasis in mice melanoma model

31 March 2020

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Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

31 March 2020

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Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models

31 March 2020

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Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor

31 March 2020

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Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1.

31 March 2020

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Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.

31 March 2020

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Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited

31 March 2020

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Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype

31 March 2020

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Semaphorin-3F is an inhibitor of tumor angiogenesis.

31 March 2020

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Selective suppression of in vivo tumorigenicity by semaphorin SEMA3F in lung cancer cells

31 March 2020

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Endogenous axon guiding chemorepulsant semaphorin-3F inhibits the growth and metastasis of colorectal carcinoma

31 March 2020

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Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism

31 March 2020

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Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis.

31 March 2020

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Hypoxia-inducible factor-1-mediated regulation of semaphorin 4D affects tumor growth and vascularity.

31 March 2020

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Semaphorin 4D cooperates with VEGF to promote angiogenesis and tumor progression.

31 March 2020

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The hypoxia-inducible factor-responsive proteins semaphorin 4D and vascular endothelial growth factor promote tumor growth and angiogenesis in oral squamous cell carcinoma

31 March 2020

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Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages

31 March 2020

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Semaphorin 6A regulates angiogenesis by modulating VEGF signaling

31 March 2020

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Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis

31 March 2020

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Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation

31 March 2020

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Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis

31 March 2020

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ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis

31 March 2020

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Plexin-B1 silencing inhibits ovarian cancer cell migration and invasion

31 March 2020

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Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells

31 March 2020

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Poor outcome in estrogen receptor-positive breast cancers predicted by loss of plexin B1

31 March 2020

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ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1.

31 March 2020

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Semaphorin receptors meet receptor tyrosine kinases on the way of tumor progression

31 March 2020

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Suppression of bone formation by osteoclastic expression of semaphorin 4D

31 March 2020

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Roles of Sema4D-plexin-B1 interactions in the central nervous system for pathogenesis of experimental autoimmune encephalomyelitis

31 March 2020

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Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin

31 March 2020

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Semaphorins in interactions between T cells and antigen-presenting cells

31 March 2020

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Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells

31 March 2020

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Identification of CD72 as a Lymphocyte Receptor for the Class IV Semaphorin CD100

31 March 2020

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Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice

31 March 2020

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Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2.

31 March 2020

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Involvement of Sema4A in the progression of experimental autoimmune myocarditis

31 March 2020

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Elevation of Sema4A implicates Th cell skewing and the efficacy of IFN-β therapy in multiple sclerosis

31 March 2020

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31 March 2020

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Neuroimmune semaphorin 4A downregulates the severity of allergic response

31 March 2020

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An inhibitory role for Sema4A in antigen-specific allergic asthma

31 March 2020

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Neuroimmune semaphorin 4A as a drug and drug target for asthma

31 March 2020

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T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation

31 March 2020

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Severe retinal degeneration associated with disruption of semaphorin 4A.

31 March 2020

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Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival

31 March 2020

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SEMA4A mutations lead to susceptibility to light irradiation, oxidative stress, and ER stress in retinal pigment epithelial cells.

31 March 2020

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A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration.

31 March 2020

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Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis

31 March 2020

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DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming

31 March 2020

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Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses

31 March 2020

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Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II

31 March 2020

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Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis

31 March 2020

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Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease

31 March 2020

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Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis.

31 March 2020

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Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via αvβ1 integrin

31 March 2020

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Semaphorin 7A is a negative regulator of T cell responses

31 March 2020

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Semaphorin-3A is expressed by tumor cells and alters T-cell signal transduction and function

31 March 2020

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The neuroimmune semaphorin-3A reduces inflammation and progression of experimental autoimmune arthritis.

31 March 2020

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Plexin-A4-semaphorin 3A signaling is required for Toll-like receptor- and sepsis-induced cytokine storm

31 March 2020

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Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention

31 March 2020

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Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity

31 March 2020

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Osteoprotection by semaphorin 3A.

31 March 2020

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An overview of the regulation of bone remodelling at the cellular level.

31 March 2020

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Sema3A regulates bone-mass accrual through sensory innervations.

31 March 2020

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Control of bone resorption by semaphorin 4D is dependent on ovarian function

31 March 2020

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Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice

31 March 2020

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Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis

31 March 2020

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Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis

31 March 2020

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Microglia and interleukin-1β in ischemic retinopathy elicit microvascular degeneration through neuronal semaphorin-3A.

31 March 2020

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Defeating inhibition of regeneration by scar and myelin components

31 March 2020

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Semaphorins in axon regeneration: developmental guidance molecules gone wrong?

31 March 2020

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In vitro and in vivo characterization of a novel semaphorin 3A inhibitor, SM-216289 or xanthofulvin.

31 March 2020

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A fungal metabolite which inhibits the interaction of CD4 with major histocompatibility complex-encoded class II molecules

31 March 2020

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A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord

31 March 2020

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The semaphorin 3A inhibitor SM-345431 accelerates peripheral nerve regeneration and sensitivity in a murine corneal transplantation model

31 March 2020

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A semaphorin 3A inhibitor blocks axonal chemorepulsion and enhances axon regeneration

31 March 2020

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PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition.

31 March 2020

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Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection.

31 March 2020

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Semaphorin III is needed for normal patterning and growth of nerves, bones and heart

31 March 2020

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Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation

31 March 2020

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Semaphorins in kidney development and disease: modulators of ureteric bud branching, vascular morphogenesis, and podocyte-endothelial crosstalk

31 March 2020

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Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells

31 March 2020

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Semaphorin 3d signaling defects are associated with anomalous pulmonary venous connections

31 March 2020

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Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins

31 March 2020

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Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition

31 March 2020

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PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla

31 March 2020

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Plexin-D1 is a novel regulator of germinal centers and humoral immune responses

31 March 2020

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Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events.

31 March 2020

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Semaphorin 3F confines ventral tangential migration of lateral olfactory tract neurons onto the telencephalon surface.

31 March 2020

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Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS.

31 March 2020

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Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin

31 March 2020

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Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1

31 March 2020

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Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses.

31 March 2020

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Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development

31 March 2020

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The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice

31 March 2020

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The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function

31 March 2020

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Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury

31 March 2020

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Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system

31 March 2020

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Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function

31 March 2020

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Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells

31 March 2020

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Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination.

31 March 2020

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The transmembrane semaphorin Sema6A controls cerebellar granule cell migration

31 March 2020

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Roles of semaphorin-6B and plexin-A2 in lamina-restricted projection of hippocampal mossy fibers.

31 March 2020

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Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing

31 March 2020

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Endothelial Semaphorin 7A promotes neutrophil migration during hypoxia

31 March 2020

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PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord

31 March 2020

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Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers

31 March 2020

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Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells

31 March 2020

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Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections

31 March 2020

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Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins.

31 March 2020

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Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance

31 March 2020

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Plexin-A4 negatively regulates T lymphocyte responses.

31 March 2020

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Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo

31 March 2020

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Semaphorin 4D regulates gonadotropin hormone-releasing hormone-1 neuronal migration through PlexinB1-Met complex

31 March 2020

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Plexin-B2 controls the development of cerebellar granule cells.

31 March 2020

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Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney

31 March 2020

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Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis

31 March 2020

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Plexin-B2 regulates the proliferation and migration of neuroblasts in the postnatal and adult subventricular zone

31 March 2020

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Mice lacking Plexin-B3 display normal CNS morphology and behaviour

31 March 2020

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Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.

31 March 2020

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PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development

31 March 2020

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Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects

31 March 2020

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Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis

31 March 2020

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Deletion of Sema4D gene reduces intimal neovascularization and plaque growth in apolipoprotein E-deficient mice

31 March 2020

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CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis

31 March 2020

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Endogenous CD100 promotes glomerular injury and macrophage recruitment in experimental crescentic glomerulonephritis.

31 March 2020

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Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation

31 March 2020

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Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling

31 March 2020

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Semaphorin7A promotes tumor growth and exerts a pro-angiogenic effect in macrophages of mammary tumor-bearing mice

31 March 2020

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Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-β1/Smad6 signaling

31 March 2020

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Intrathecally administered Sema3A protein attenuates neuropathic pain behavior in rats with chronic constriction injury of the sciatic nerve

31 March 2020

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The axonal guidance cue semaphorin 3C contributes to alveolar growth and repair.

31 March 2020

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Semaphorin 6A improves functional recovery in conjunction with motor training after cerebral ischemia

31 March 2020

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Semaphorin 7a links nerve regeneration and inflammation in the cornea

31 March 2020

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Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization

31 March 2020

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12 December 2020

Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice

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12 December 2020

Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models

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12 December 2020

Bone cells and the mechanisms of bone remodelling

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12 December 2020

Dual functional activity of semaphorin 3B is required for positioning the anterior commissure

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12 December 2020

Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption

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12 December 2020

Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling

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12 December 2020

Identifiers

DOI

10.1038/NRD4337

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Dimensions Publication ID

31 August 2017

1045811454

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