(Q38240617)

31 August 2017

title

Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemia (English)

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31 August 2017

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2

Hugues de Thé

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Julien Ablain

series ordinal

1

object named as

Julien Ablain

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31 August 2017

language of work or name

English

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publication date

14 August 2014

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International Journal of Cancer

31 August 2017

published in

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31 August 2017

volume

135

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31 August 2017

issue

10

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31 August 2017

page(s)

2262-2272

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The induction of differentiation in teratocarcinoma stem cells by retinoic acid

31 August 2017

cites work

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Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid

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A human retinoic acid receptor which belongs to the family of nuclear receptors

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Identification of a receptor for the morphogen retinoic acid

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The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

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Retinoic acid synthesis and signaling during early organogenesis

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The nuclear receptor superfamily: the second decade

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Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently

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Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene

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The role of corepressors in transcriptional regulation by nuclear hormone receptors

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Mechanism of the nuclear receptor molecular switch

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Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins

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Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element

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Protein kinases and the proteasome join in the combinatorial control of transcription by nuclear retinoic acid receptors

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Small ubiquitin-like modifier-2 modification of retinoic acid receptor-alpha regulates its subcellular localization and transcriptional activity

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Vitamin A and retinoid signaling: genomic and nongenomic effects

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Retinoic acid signalling during development

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Retinoic acid signaling is essential for embryonic hematopoietic stem cell development

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Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling

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Positive and negative regulation of granulopoiesis by endogenous RARalpha

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RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation

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Retinoids, retinoic acid receptors, and cancer

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Esterification of all-trans-retinol in normal human epithelial cell strains and carcinoma lines from oral cavity, skin and breast: reduced expression of lecithin:retinol acyltransferase in carcinoma lines

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The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer

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Oncogenic and cell survival properties of the retinoic acid metabolizing enzyme, CYP26A1.

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Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells

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Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17

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Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias

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The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus

21 January 2018

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Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

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The incidence of acute promyelocytic leukemia appears constant over most of a human lifespan, implying only one rate limiting mutation

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The origin and evolution of mutations in acute myeloid leukemia

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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

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Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

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A PMLRARalpha transgene initiates murine acute promyelocytic leukemia

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Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice

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Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia

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PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

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Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice

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Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers.

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Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

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Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

21 January 2018

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Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

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Role of the histone deacetylase complex in acute promyelocytic leukaemia

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PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia

21 January 2018

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Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

21 January 2018

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Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

21 January 2018

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Reconstructing a disease: What essential features of the retinoic acid receptor fusion oncoproteins generate acute promyelocytic leukemia?

21 January 2018

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Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia

21 January 2018

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Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M. D. Anderson Cancer Center Series.

21 January 2018

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Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

21 January 2018

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Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia

21 January 2018

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Revisiting the differentiation paradigm in acute promyelocytic leukemia

21 January 2018

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Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies

21 January 2018

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Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission

21 January 2018

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PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3.

21 January 2018

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Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.

21 January 2018

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Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

21 January 2018

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RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

21 January 2018

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Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: long-term follow-up data

21 January 2018

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Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells

21 January 2018

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Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo

21 January 2018

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Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia

21 January 2018

1 reference

Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

21 January 2018

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All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia

21 January 2018

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Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia

21 January 2018

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Retinoic acid and arsenic trioxide for acute promyelocytic leukemia

21 January 2018

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Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells

21 January 2018

1 reference

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

21 January 2018

1 reference

PML nuclear bodies in the pathogenesis of acute promyelocytic leukemia: active players or innocent bystanders?

21 January 2018

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Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

21 January 2018

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21 January 2018

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The tumor suppressor Pml regulates cell fate in the developing neocortex

21 January 2018

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PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool

21 January 2018

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PML targeting eradicates quiescent leukaemia-initiating cells

21 January 2018

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Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation

21 January 2018

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PML nuclear bodies: dynamic sensors of DNA damage and cellular stress

21 January 2018

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Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

21 January 2018

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p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal

21 January 2018

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Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations

21 January 2018

1 reference

Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia

21 January 2018

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Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia

21 January 2018

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Leukocytosis and the retinoic acid syndrome in patients with acute promyelocytic leukemia treated with arsenic trioxide

21 January 2018

1 reference

PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.

21 January 2018

1 reference

New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor α recruitment to gene promoters: relevance to acute promyelocytic leukemia cell differentiation.

21 January 2018

1 reference

PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation

21 January 2018

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Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization

21 January 2018

1 reference

Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia

21 January 2018

1 reference

The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein

21 January 2018

1 reference

Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein

21 January 2018

1 reference

SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia

21 January 2018

1 reference

RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia

21 January 2018

1 reference

Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC

21 January 2018

1 reference

Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies

21 January 2018

1 reference

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

21 January 2018

1 reference

Two critical hits for promyelocytic leukemia

21 January 2018

1 reference

The drug-induced degradation of oncoproteins: an unexpected Achilles' heel of cancer cells?

21 January 2018

1 reference

Cancer revoked: oncogenes as therapeutic targets

21 January 2018

1 reference

Differentiation therapy of acute myeloid leukemia: past, present and future

21 January 2018

1 reference

The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia

21 January 2018

1 reference

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

21 January 2018

1 reference

Molecular pathways: current role and future directions of the retinoic acid pathway in cancer prevention and treatment

21 January 2018

1 reference

Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: multinational phase II-III trial results

21 January 2018

1 reference

Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group

21 January 2018

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Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells

21 January 2018

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Retinoic acid receptor beta mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.29081

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31 August 2017

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