(Q38241769)

31 August 2017

title

CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders (English)

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31 August 2017

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3

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31 August 2017

2

Toshikatsu Hanada

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31 August 2017

Stefan Weitzer

1

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31 August 2017

Javier Martinez

series ordinal

4

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31 August 2017

publication date

20 August 2014

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Wiley interdisciplinary reviews. RNA

31 August 2017

published in

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31 August 2017

volume

6

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31 August 2017

issue

1

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31 August 2017

page(s)

47-63

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tRNA biology charges to the front

31 August 2017

cites work

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The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases

21 January 2018

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Splicing of yeast tRNA precursors: a two-stage reaction

21 January 2018

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Mechanism of action of a yeast RNA ligase in tRNA splicing

21 January 2018

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HSPC117 is the essential subunit of a human tRNA splicing ligase complex

21 January 2018

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Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors

21 January 2018

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5' end maturation and RNA editing have to precede tRNA 3' processing in plant mitochondria

21 January 2018

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Assigning a function to a conserved group of proteins: the tRNA 3'-processing enzymes

21 January 2018

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Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation

21 January 2018

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The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs

21 January 2018

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The major yeast poly(A)-binding protein is associated with cleavage factor IA and functions in premessenger RNA 3'-end formation

21 January 2018

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Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors

21 January 2018

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CLP1 links tRNA metabolism to progressive motor-neuron loss

21 January 2018

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A novel class of small RNAs: tRNA-derived RNA fragments (tRFs).

21 January 2018

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Transfer RNA-derived fragments: origins, processing, and functions

21 January 2018

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Slicing tRNAs to boost functional ncRNA diversity

21 January 2018

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Genome-wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress

21 January 2018

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Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function

21 January 2018

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CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration

21 January 2018

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tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia

21 January 2018

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Classification, diagnosis and potential mechanisms in pontocerebellar hypoplasia

21 January 2018

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Protein factors in pre-mRNA 3'-end processing.

21 January 2018

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Pre-mRNA 3'-end processing complex assembly and function

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The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II.

21 January 2018

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Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites

21 January 2018

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Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I.

21 January 2018

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The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation

21 January 2018

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The essential N terminus of the Pta1 scaffold protein is required for snoRNA transcription termination and Ssu72 function but is dispensable for pre-mRNA 3'-end processing.

21 January 2018

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The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site

21 January 2018

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Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor

21 January 2018

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RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1

21 January 2018

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Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo

21 January 2018

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The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation

21 January 2018

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An essential role for Clp1 in assembly of polyadenylation complex CF IA and Pol II transcription termination

21 January 2018

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Cotranscriptional recruitment of the mRNA export factor Yra1 by direct interaction with the 3' end processing factor Pcf11.

21 January 2018

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The export factor Yra1 modulates mRNA 3' end processing.

21 January 2018

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CBC-ARS2 stimulates 3'-end maturation of multiple RNA families and favors cap-proximal processing.

21 January 2018

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Plant tRNA ligases are multifunctional enzymes that have diverged in sequence and substrate specificity from RNA ligases of other phylogenetic origins

21 January 2018

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Genetic and biochemical analysis of the functional domains of yeast tRNA ligase

21 January 2018

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Conserved mechanism of tRNA splicing in eukaryotes

21 January 2018

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Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

21 January 2018

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Mammalian 2',3' cyclic nucleotide phosphodiesterase (CNP) can function as a tRNA splicing enzyme in vivo

21 January 2018

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A 2'-phosphotransferase implicated in tRNA splicing is essential in Saccharomyces cerevisiae

21 January 2018

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An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation

21 January 2018

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A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation

21 January 2018

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Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery

21 January 2018

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Identification of the mouse neuromuscular degeneration gene and mapping of a second site suppressor allele

21 January 2018

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Mutations in the gene encoding immunoglobulin mu-binding protein 2 cause spinal muscular atrophy with respiratory distress type 1

21 January 2018

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RIG-I-like receptors: cytoplasmic sensors for non-self RNA.

21 January 2018

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Nucleic acid recognition by the innate immune system

21 January 2018

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IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA

21 January 2018

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21 January 2018

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Unexpected functions of tRNA and tRNA processing enzymes

21 January 2018

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Stress induces tRNA cleavage by angiogenin in mammalian cells

21 January 2018

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tRNA cleavage is a conserved response to oxidative stress in eukaryotes

21 January 2018

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tRNA structural and functional changes induced by oxidative stress

21 January 2018

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Starvation-induced cleavage of the tRNA anticodon loop in Tetrahymena thermophila

21 January 2018

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Angiogenin cleaves tRNA and promotes stress-induced translational repression

21 January 2018

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The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae

21 January 2018

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Tight-binding inhibition of angiogenin and ribonuclease A by placental ribonuclease inhibitor

21 January 2018

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The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5

21 January 2018

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Reversible and rapid transfer-RNA deactivation as a mechanism of translational repression in stress.

21 January 2018

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Angiogenin-induced tRNA fragments inhibit translation initiation

21 January 2018

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Transfer RNA post-transcriptional processing, turnover, and subcellular dynamics in the yeast Saccharomyces cerevisiae

21 January 2018

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Coordination of tRNA nuclear export with processing of tRNA.

21 January 2018

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Proofreading and aminoacylation of tRNAs before export from the nucleus.

21 January 2018

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21 January 2018

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Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse origin.

21 January 2018

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tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma.

21 January 2018

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Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

21 January 2018

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Small RNAs derived from the 5' end of tRNA can inhibit protein translation in human cells

21 January 2018

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Human tRNA-derived small RNAs in the global regulation of RNA silencing

21 January 2018

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Signal transduction by reactive oxygen species

21 January 2018

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Differential RNAi screening provides insights into the rewiring of signalling networks during oxidative stress.

21 January 2018

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ROS are required for mouse spermatogonial stem cell self-renewal

21 January 2018

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Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis

21 January 2018

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Identification of p53 as a sequence-specific DNA-binding protein

21 January 2018

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Analysis of p53-RNA interactions in cultured human cells

21 January 2018

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ATM activation by oxidative stress

21 January 2018

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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tRNA and cytochrome c in cell death and beyond.

21 January 2018

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tRNA binds to cytochrome c and inhibits caspase activation

21 January 2018

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Pontocerebellar hypoplasia type 2 and TSEN2: review of the literature and two novel mutations

21 January 2018

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Aminoacyl-tRNA synthetases in medicine and disease

21 January 2018

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TSEN54 mutations cause pontocerebellar hypoplasia type 5

21 January 2018

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Impairment of the tRNA-splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of pontocerebellar hypoplasia

21 January 2018

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Exome sequencing in a family with intellectual disability, early onset spasticity, and cerebellar atrophy detects a novel mutation in EXOSC3.

21 January 2018

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EXOSC3 mutations in isolated cerebellar hypoplasia and spinal anterior horn involvement

21 January 2018

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Homozygous EXOSC3 mutation c.92G→C, p.G31A is a founder mutation causing severe pontocerebellar hypoplasia type 1 among the Czech Roma

21 January 2018

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Mutations in the RNA exosome component gene EXOSC3 cause pontocerebellar hypoplasia and spinal motor neuron degeneration

21 January 2018

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Pontocerebellar hypoplasia type 1: clinical spectrum and relevance of EXOSC3 mutations

21 January 2018

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AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder

21 January 2018

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Role of p53 in neurodegenerative diseases

21 January 2018

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The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

21 January 2018

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VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage

21 January 2018

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Spinal muscular atrophy with pontocerebellar hypoplasia is caused by a mutation in the VRK1 gene

21 January 2018

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Clinical, neuroradiological and genetic findings in pontocerebellar hypoplasia

21 January 2018

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The role of aminoacyl-tRNA synthetases in genetic diseases

21 January 2018

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Latent and active p53 are identical in conformation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/WRNA.1255

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31 August 2017

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