(Q38245896)

31 August 2017

title

Physiology and pathophysiology of the renal Na-K-2Cl cotransporter (NKCC2). (English)

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31 August 2017

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Hayo Castrop

1

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31 August 2017

Ina Maria Schießl

series ordinal

2

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31 August 2017

language of work or name

1 reference

3 September 2014

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American Journal of Physiology - Renal Physiology

31 August 2017

published in

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31 August 2017

volume

307

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31 August 2017

issue

9

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31 August 2017

page(s)

F991-F1002

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Rare mutations in SLC12A1 and SLC12A3 protect against hypertension by reducing the activity of renal salt cotransporters

31 August 2017

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Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter

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Effects of NKCC2 isoform regulation on NaCl transport in thick ascending limb and macula densa: a modeling study

21 January 2018

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Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion

21 January 2018

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21 January 2018

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Molecular mechanisms of Cl- transport by the renal Na(+)-K(+)-Cl- cotransporter. Identification of an intracellular locus that may form part of a high affinity Cl(-)-binding site

21 January 2018

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Molecular mechanisms of cation transport by the renal Na+-K+-Cl- cotransporter: structural insight into the operating characteristics of the ion transport sites

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The residues determining differences in ion affinities among the alternative splice variants F, A, and B of the mammalian renal Na-K-Cl cotransporter (NKCC2).

21 January 2018

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Short-term stimulation of the renal Na-K-Cl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein.

21 January 2018

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Spatially distributed alternative splice variants of the renal Na-K-Cl cotransporter exhibit dramatically different affinities for the transported ions.

21 January 2018

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Modulation of splicing events in histone deacetylase 3 by various extracellular and signal transduction pathways.

21 January 2018

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Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron

21 January 2018

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SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.

21 January 2018

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Quantitative phosphoproteomic analysis reveals cAMP/vasopressin-dependent signaling pathways in native renal thick ascending limb cells

21 January 2018

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Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension

21 January 2018

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Race, sex, and the regulation of urine osmolality: observations made during water deprivation

21 January 2018

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Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs

21 January 2018

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Differential regulation of NFAT5 by NKCC2 isoforms in medullary thick ascending limb (mTAL) cells

21 January 2018

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β-Adrenergic receptor stimulation increases surface NKCC2 expression in rat thick ascending limbs in a process inhibited by phosphodiesterase 4.

21 January 2018

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Molecular cloning and characterization of the renal diuretic-sensitive electroneutral sodium-(potassium)-chloride cotransporters.

21 January 2018

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The medullary thick limb: function and modulation of the single-effect multiplier

21 January 2018

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Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric oxide production

21 January 2018

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Cloning, embryonic expression, and alternative splicing of a murine kidney-specific Na-K-Cl cotransporter

21 January 2018

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Cloning and kidney cell-specific activity of the promoter of the murine renal Na-K-C1 cotransporter gene

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Cellular distribution of NKCC2 in the gastric mucosa and its response to short-term osmotic shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Association of the calcium-sensing receptor gene with blood pressure and urinary calcium in African-Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

The transition of the thick ascending limb of Henle's loop into the distal convoluted tubule in the nephron of the rat kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Gene structure prediction and alternative splicing analysis using genomically aligned ESTs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Mutation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in mice is associated with severe polyuria and a urea-selective concentrating defect without hyperreninemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Importance of chloride for acute inhibition of renin by sodium chloride

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Kidney morphogenesis: cellular and molecular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Direct evidence for apical Na+:2Cl-:K+ cotransport in macula densa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Effect of Na and Cl infusion on loop function and plasma renin activity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Renin release from isolated juxtaglomerular apparatus depends on macula densa chloride transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Functional consequences of NKCC2 splice isoforms: insights from a Xenopus oocyte model

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

A SPAK isoform switch modulates renal salt transport and blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

cAMP-dependent activation of the renal-specific Na+-K+-2Cl- cotransporter is mediated by regulation of cotransporter trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Rare mutations in the human Na-K-Cl cotransporter (NKCC2) associated with lower blood pressure exhibit impaired processing and transport function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Pathogenetic role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome: therapeutic use of the cyclooxygenase-2 inhibitor nimesulide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Expression of the Na-K-2Cl cotransporter by macula densa and thick ascending limb cells of rat and rabbit nephron

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

A variant of Bartter's syndrome. Bartter's syndrome associated with hydramnios, prematurity, hypercalciuria and nephrocalcinosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Renal function in mice with targeted disruption of the A isoform of the Na-K-2Cl co-transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

cAMP increases surface expression of NKCC2 in rat thick ascending limbs: role of VAMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

NO Inhibits NaCl absorption by rat thick ascending limb through activation of cGMP-stimulated phosphodiesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

NO decreases thick ascending limb chloride absorption by reducing Na(+)-K(+)-2Cl(-) cotransporter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

WNK3 is a putative chloride-sensing kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Alternatively spliced isoforms of the putative renal Na-K-Cl cotransporter are differentially distributed within the rabbit kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Alternatively spliced isoform of apical Na(+)-K(+)-Cl(-) cotransporter gene encodes a furosemide-sensitive Na(+)-Cl(-)cotransporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Functional properties of the apical Na+-K+-2Cl- cotransporter isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Bartter syndrome and its neonatal variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Role of the WNK-activated SPAK kinase in regulating blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

The many roles of the calcium-sensing receptor in health and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Sodium chloride and water transport in the medullary thick ascending limb of Henle. Evidence for active chloride transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Dietary salt intake modulates differential splicing of the Na-K-2Cl cotransporter NKCC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Tubular control of renin synthesis and secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Role of prostaglandins in hyperprostaglandin E syndrome and in selected renal tubular disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Congenital hypokalemia with hypercalciuria in preterm infants: a hyperprostaglandinuric tubular syndrome different from Bartter syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Inherited primary renal tubular hypokalemic alkalosis: a review of Gitelman and Bartter syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Direct demonstration of macula densa-mediated renin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Mediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Uncompensated polyuria in a mouse model of Bartter's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

A consideration of genetic mechanisms behind the development of hypertension in blacks

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Mechanism of the effects of furosemide on renin secretion in anesthetized dogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Novel molecular variants of the Na-K-2Cl cotransporter gene are responsible for antenatal Bartter syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Classic Bartter syndrome: a rare cause of failure to thrive in a child

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Hypotension in NKCC1 null mice: role of the kidneys

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Cytochrome P-450 metabolites mediate extracellular Ca(2+)-induced inhibition of apical K+ channels in the TAL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Whites excrete a water load more rapidly than blacks

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Human hypertension caused by mutations in WNK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Interference with Feedback Control of Glomerular Filtration Rate by Furosemide, Triflocin, and Cyanide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Expression of NKCC2 in the rat gastrointestinal tract.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Stimulation by angiotensin II, bradykinin, and arginine vasopressin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

Decreased renal Na-K-2Cl cotransporter abundance in mice with heterozygous disruption of the G(s)alpha gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00432.2014

10.1152/AJPRENAL.00432.2014

21 January 2018

Identifiers

DOI

1 reference

31 August 2017

1 reference