(Q34457030)

2 August 2017

title

SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction (English)

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ORCID Public Data File 2021

2 August 2017

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author name string

Sung-Sen Yang

1

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2 August 2017

Yi-Fen Lo

2

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2 August 2017

Chin-Chen Wu

3

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2 August 2017

Shu-Wha Lin

4

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2 August 2017

Chien-Ju Yeh

5

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2 August 2017

Pauling Chu

6

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2 August 2017

Huey-Kang Sytwu

7

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2 August 2017

Shinichi Uchida

8

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2 August 2017

Sei Sasaki

9

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2 August 2017

Shih-Hua Lin

10

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2 August 2017

publication date

2 September 2010

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Journal of the American Society of Nephrology

2 August 2017

published in

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2 August 2017

volume

21

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2 August 2017

issue

11

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2 August 2017

page(s)

1868-1877

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Mechanisms for hypercalciuria in pseudohypoaldosteronism type II-causing WNK4 knock-in mice

2 August 2017

cites work

1 reference

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Hypocalciuria in patients with Gitelman syndrome: role of blood volume

6 July 2018

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Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone

6 July 2018

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The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion

6 July 2018

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Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

6 July 2018

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6 July 2018

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WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

6 July 2018

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The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

6 July 2018

1 reference

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NO and KATP channels underlie endotoxin-induced smooth muscle hyperpolarization in rat mesenteric resistance arteries

6 July 2018

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Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase

6 July 2018

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6 July 2018

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Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)

6 July 2018

1 reference

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6 July 2018

1 reference

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SPAK, a STE20/SPS1-related kinase that activates the p38 pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014002

Vasoconstrictors and nitrovasodilators reciprocally regulate the Na+-K+-2Cl- cotransporter in rat aorta.

6 July 2018

1 reference

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Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3

6 July 2018

1 reference

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Molecular cloning and characterization of a novel Ste20-related protein kinase enriched in neurons and transporting epithelia

6 July 2018

1 reference

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A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission.

6 July 2018

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Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2

6 July 2018

1 reference

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Distribution and diversity of Na-K-Cl cotransport proteins: a study with monoclonal antibodies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014002

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014002

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014002

Cell-volume-dependent vascular smooth muscle contraction: role of Na+, K+, 2Cl- cotransport, intracellular Cl- and L-type Ca2+ channels

27 October 2018

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Aldosterone regulates the Na-K-2Cl cotransporter in vascular smooth muscle

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014002

Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014002

Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014002

Contractile regulation of the Na(+)-K(+)-2Cl(-) cotransporter in vascular smooth muscle

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014002

Expression of mixed lineage kinase-1 in pancreatic beta-cell lines at different stages of maturation and during embryonic pancreas development.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014002

The syndrome of hypertension and hyperkalaemia without renal failure: long term correction by thiazide diuretic

27 October 2018

1 reference

12 December 2020

Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule

1 reference

12 December 2020

Phenotype and genotype analysis in Chinese patients with Gitelman's syndrome

1 reference

12 December 2020

NKCC1 as a regulator of vascular tone and a novel target for antihypertensive therapeutics

1 reference

12 December 2020

Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model

1 reference

12 December 2020

Effects of furosemide on renal calcium handling

1 reference

12 December 2020

Plasma creatinine determination in mice and rats: an enzymatic method compares favorably with a high-performance liquid chromatography assay

1 reference

12 December 2020

Identifiers

DOI

10.1681/ASN.2009121295

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2 August 2017

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2 August 2017

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