(Q38247344)

1 September 2017

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title

Role of O-GlcNAcylation in nutritional sensing, insulin resistance and in mediating the benefits of exercise (English)

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1 September 2017

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Jason P Myslicki

1

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1 September 2017

Darrell D Belke

series ordinal

2

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1 September 2017

Jane Shearer

series ordinal

3

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1 September 2017

publication date

28 July 2014

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Applied Physiology, Nutrition, and Metabolism

1 September 2017

published in

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1 September 2017

volume

39

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1 September 2017

issue

11

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1 September 2017

page(s)

1205-1213

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Identification of the major site of O-linked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1.

1 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Short-term treadmill running in the rat: what kind of stressor is it?

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Identification of protein O-GlcNAcylation sites using electron transfer dissociation mass spectrometry on native peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Role of diet and fuel overabundance in the development and progression of heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Activation of PPARgamma negatively regulates O-GlcNAcylation of Sp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Diabetes and the accompanying hyperglycemia impairs cardiomyocyte calcium cycling through increased nuclear O-GlcNAcylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Exercise and diabetes have opposite effects on the assembly and O-GlcNAc modification of the mSin3A/HDAC1/2 complex in the heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Depressed PKA activity contributes to impaired SERCA function and is linked to the pathogenesis of glucose-induced cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Changes in mRNA levels for brain-derived neurotrophic factor after wheel running in rats selectively bred for high- and low-aerobic capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockout

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Role of the glucosamine pathway in fat-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Site-specific interplay between O-GlcNAcylation and phosphorylation in cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Adenovirus-mediated overexpression of O-GlcNAcase improves contractile function in the diabetic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Regulation of a cytosolic and nuclear O-GlcNAc transferase. Role of the tetratricopeptide repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Post-translational modification by O-GlcNAc: another way to change protein function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Exercise Training Prevents Coronary Endothelial Dysfunction in Type 2 Diabetic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Gene regulation by Sp1 and Sp3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

High-fat diet enhances visceral advanced glycation end products, nuclear O-Glc-Nac modification, p38 mitogen-activated protein kinase activation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Protein O-GlcNAcylation in diabetes and diabetic complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

O-GlcNAc profiling: from proteins to proteomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulate hypertrophic and cell signaling pathways in cardiomyocytes from diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Hexosamines as mediators of nutrient sensing and regulation in diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Hexosamines and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Chronic ingestion of a Western diet increases O-linked-β-N-acetylglucosamine (O-GlcNAc) protein modification in the rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Immediate effects of a single exercise bout on protein O-GlcNAcylation and chromatin regulation of cardiac hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

O-GlcNAc signaling in the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Modulation of transcription factor function by O-GlcNAc modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals with pre-diabetes and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Diastolic dysfunction in normotensive men with well-controlled type 2 diabetes: importance of maneuvers in echocardiographic screening for preclinical diabetic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

O-linked GlcNAc modification of cardiac myofilament proteins: a novel regulator of myocardial contractile function

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

O-GlcNAc cycling: how a single sugar post-translational modification is changing the way we think about signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Exploring leukocyte O-GlcNAcylation as a novel diagnostic tool for the earlier detection of type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Acceleration of stretch activation in murine myocardium due to phosphorylation of myosin regulatory light chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Adaptation and maladaptation of the heart in diabetes: Part I: general concepts

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Streptozotocin inhibits O-GlcNAcase via the production of a transition state analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

dbOGAP - an integrated bioinformatics resource for protein O-GlcNAcylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Site-specific GlcNAcylation of human erythrocyte proteins: potential biomarker(s) for diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Cardiomyocyte Ogt is essential for postnatal viability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Proteomic approaches to analyze the dynamic relationships between nucleocytoplasmic protein glycosylation and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Sp1: emerging roles--beyond constitutive activation of TATA-less housekeeping genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Adaptation and maladaptation of the heart in diabetes: Part II: potential mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

The dynamic stress-induced “O-GlcNAc-ome” highlights functions for O-GlcNAc in regulating DNA damage/repair and other cellular pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

Glucose deprivation-induced increase in protein O-GlcNAcylation in cardiomyocytes is calcium-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1139%2FAPNM-2014-0122

21 January 2018

Identifiers

DOI

10.1139/APNM-2014-0122

1 reference

1 September 2017

1 reference