(Q24648559)

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Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20018868%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes (English)

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15 January 2020

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Stephen A Whelan

1

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15 January 2020

Stephen A Whelan

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15 January 2020

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15 January 2020

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Lakshmanan Thiruneelakantapillai

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15 January 2020

M Daniel Lane

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15 January 2020

Gerald W Hart

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17 December 2009

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15 January 2020

Journal of Biological Chemistry

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15 January 2020

285

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15 January 2020

5204-5211

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15 January 2020

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15 January 2020

describes a project that uses

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Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

1 reference

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7 April 2017

Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer

1 reference

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7 April 2017

Hexosamines, insulin resistance, and the complications of diabetes: current status

1 reference

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7 April 2017

Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

1 reference

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7 April 2017

Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

7 April 2017

Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

7 April 2017

Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

7 April 2017

O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

7 April 2017

Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats

1 reference

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7 April 2017

The hexosamine signaling pathway: deciphering the "O-GlcNAc code"

1 reference

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7 April 2017

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

1 reference

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7 April 2017

The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine

1 reference

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7 April 2017

c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

7 April 2017

O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

7 April 2017

The protein kinase B/Akt signalling pathway in human malignancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

7 April 2017

Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

7 April 2017

Insulin increases the association of Akt-2 with Glut4-containing vesicles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

7 April 2017

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

7 April 2017

Glycan-dependent signaling: O-linked N-acetylglucosamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

26 May 2017

O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

O-linked beta-N-acetylglucosaminylation in mouse embryonic neural precursor cells

1 reference

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28 September 2017

Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

Regulation of the O-linked beta-N-acetylglucosamine transferase by insulin signaling.

1 reference

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28 September 2017

O-GlcNAc regulates FoxO activation in response to glucose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

o-GlcNAc transferase is activated by CaMKIV-dependent phosphorylation under potassium chloride-induced depolarization in NG-108-15 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

Reduction of O-GlcNAc protein modification does not prevent insulin resistance in 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

Cell signaling, the essential role of O-GlcNAc!

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

Identification of the major site of O-linked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

O-GlcNAc cycling: how a single sugar post-translational modification is changing the way we think about signaling networks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

Proteomic approaches to analyze the dynamic relationships between nucleocytoplasmic protein glycosylation and phosphorylation

1 reference

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28 September 2017

A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

O-GlcNAc: a regulatory post-translational modification.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling

1 reference

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28 September 2017

Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAc

1 reference

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28 September 2017

Cellular signaling: pivoting around PDK-1.

1 reference

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28 September 2017

Effect of okadaic acid on O-linked N-acetylglucosamine levels in a neuroblastoma cell line

1 reference

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28 September 2017

Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

Insulin-dependent phosphorylation of the insulin receptor-protein kinase and activation of glucose transport in 3T3-L1 adipocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 September 2017

Reciprocal keratin 18 Ser48 O-GlcNAcylation and Ser52 phosphorylation using peptide analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

30 May 2018

High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

30 May 2018

Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

30 May 2018

The insulin signalling system and the IRS proteins

1 reference

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30 May 2018

Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit

1 reference

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30 May 2018

N-acetylglucosaminono-1,5-lactone oxime and the corresponding (phenylcarbamoyl)oxime. Novel and potent inhibitors of beta-N-acetylglucosaminidase

1 reference

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30 May 2018

Post-translational modification by O-GlcNAc: another way to change protein function.

1 reference

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28 November 2018

Discovery of O-GlcNAc transferase inhibitors

1 reference

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28 November 2018

Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820748

28 November 2018

Reciprocity between O-GlcNAc and O-phosphate on the carboxyl terminal domain of RNA polymerase II.

1 reference

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28 November 2018

Glucose and insulin regulate insulin sensitivity in primary cultured adipocytes without affecting insulin receptor kinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20018868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNA polymerase II is a glycoprotein. Modification of the COOH-terminal domain by O-GlcNAc

1 reference

https://pubmed.ncbi.nlm.nih.gov/20018868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20018868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/20018868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of O-GlcNAc sites on proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20018868

12 December 2020

based on heuristic

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Identifiers

10.1074/JBC.M109.077818

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15 January 2020

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Europe PubMed Central

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15 January 2020

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Europe PubMed Central

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15 January 2020

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