(Q38256796)

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TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

scientific article published on 13 December 2013

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scholarly article

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Europe PubMed Central

1 September 2017

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy (English)

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1 September 2017

2

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11 June 2020

author name string

Meryem Alagoz

1

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11 June 2020

Sherif F El-Khamisy

3

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11 June 2020

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publication date

13 December 2013

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1 September 2017

Nucleic Acids Research

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11 June 2020

42

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11 June 2020

5

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11 June 2020

3089-3103

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11 June 2020

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Creative Commons Attribution 3.0 Unported

4 October 2016

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April 2022 Public Data File from Crossref

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Processing of damaged DNA ends for double-strand break repair in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

Balancing repair and tolerance of DNA damage caused by alkylating agents

1 reference

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6 September 2017

Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability

1 reference

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6 September 2017

Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas

1 reference

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6 September 2017

Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines

1 reference

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6 September 2017

The DNA Damage Response: Making It Safe to Play with Knives

1 reference

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6 September 2017

Small molecule inhibitors of DNA repair nuclease activities of APE1.

1 reference

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6 September 2017

Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases

1 reference

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6 September 2017

Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90

1 reference

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6 September 2017

DNA base repair--recognition and initiation of catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

Single-strand break repair and genetic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

Topoisomerase I inhibitors: camptothecins and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

Molecular and biological roles of Ape1 protein in mammalian base excision repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

Isolation of a small molecule inhibitor of DNA base excision repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

1 reference

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6 September 2017

Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone.

1 reference

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6 September 2017

Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA

1 reference

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6 September 2017

Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

1 reference

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6 September 2017

Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine

1 reference

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6 September 2017

DNA adduct formation from tobacco-specific N-nitrosamines

1 reference

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6 September 2017

A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

1 reference

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6 September 2017

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

1 reference

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6 September 2017

Instability and decay of the primary structure of DNA

1 reference

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6 September 2017

Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction

1 reference

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Rate of depurination of native deoxyribonucleic acid

1 reference

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6 September 2017

Mutagenesis by apurinic/apyrimidinic sites

1 reference

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6 September 2017

SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.

1 reference

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6 September 2017

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3950670

6 September 2017

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate

1 reference

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14 September 2017

TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage

1 reference

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14 September 2017

Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents

1 reference

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28 September 2017

Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites

1 reference

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23 June 2018

AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe

1 reference

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Intercellular karyotypic similarity in near-diploid cell lines of human tumor origins

1 reference

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23 June 2018

Measurement of chromosomal DNA single-strand breaks and replication fork progression rates.

1 reference

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31 August 2018

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24335147

12 December 2020

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10.1093/NAR/GKT1260

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Europe PubMed Central

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11 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24335147%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24335147%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

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