(Q38262473)

1 September 2017

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title

Revisiting STAT3 signalling in cancer: new and unexpected biological functions (English)

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1 September 2017

Hua Yu

1

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1 September 2017

Heehyoung Lee

2

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1 September 2017

Andreas Herrmann

3

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1 September 2017

Ralf Buettner

4

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1 September 2017

Richard Jove

5

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1 September 2017

language of work or name

English

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publication date

1 November 2014

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1 September 2017

published in

Nature Reviews Cancer

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1 September 2017

volume

14

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1 September 2017

issue

11

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1 September 2017

page(s)

736-746

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https://scigraph.springernature.com/pub.10.1038/nrc3818

1 September 2017

exact match

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cites work

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

31 March 2020

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How cells respond to interferons

31 March 2020

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The STATs of cancer--new molecular targets come of age

31 March 2020

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Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer

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STATs in cancer inflammation and immunity: a leading role for STAT3

31 March 2020

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The role of STATs in transcriptional control and their impact on cellular function

31 March 2020

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Targeting Stat3 in the myeloid compartment drastically improves the in vivo antitumor functions of adoptively transferred T cells

31 March 2020

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Role of Stat3 in suppressing anti-tumor immunity

31 March 2020

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Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice

31 March 2020

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IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway

31 March 2020

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Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

31 March 2020

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Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.

31 March 2020

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Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice.

31 March 2020

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Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance

31 March 2020

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S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.

31 March 2020

1 reference

Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression

31 March 2020

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The transcriptional network for mesenchymal transformation of brain tumours.

31 March 2020

1 reference

The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors

31 March 2020

1 reference

Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling

31 March 2020

1 reference

Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity.

31 March 2020

1 reference

Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy

31 March 2020

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Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer

31 March 2020

1 reference

STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation.

31 March 2020

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TLR9 is critical for glioma stem cell maintenance and targeting

31 March 2020

1 reference

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

31 March 2020

1 reference

Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transition

31 March 2020

1 reference

Let-7 expression is a significant determinant of response to chemotherapy through the regulation of IL-6/STAT3 pathway in esophageal squamous cell carcinoma

31 March 2020

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Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma.

31 March 2020

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miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers

31 March 2020

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STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.

31 March 2020

1 reference

G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.

31 March 2020

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Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

31 March 2020

1 reference

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

31 March 2020

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

31 March 2020

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Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

31 March 2020

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IL-11: a prominent pro-tumorigenic member of the IL-6 family

31 March 2020

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gp130 at the nexus of inflammation, autoimmunity, and cancer

31 March 2020

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Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

31 March 2020

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A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis

31 March 2020

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More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer.

31 March 2020

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The gp130 receptor cytokine family: regulators of adipocyte development and function.

31 March 2020

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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

31 March 2020

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gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

31 March 2020

1 reference

Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages

31 March 2020

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Role of the microenvironment in mantle cell lymphoma: IL-6 is an important survival factor for the tumor cells

31 March 2020

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IL-6 involvement in epithelial cancers

31 March 2020

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IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

31 March 2020

1 reference

Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer

31 March 2020

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The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis

31 March 2020

1 reference

Inflammation and cancer: IL-6 and STAT3 complete the link.

31 March 2020

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Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

31 March 2020

1 reference

Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model

31 March 2020

1 reference

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

31 March 2020

1 reference

Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance.

31 March 2020

1 reference

TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma.

31 March 2020

1 reference

IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development

31 March 2020

1 reference

Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.

31 March 2020

1 reference

A new regulation of IL-6 production in adult cardiomyocytes by beta-adrenergic and IL-1 beta receptors and induction of cellular hypertrophy by IL-6 trans-signalling

31 March 2020

1 reference

Tumor angiogenesis mediated by myeloid cells is negatively regulated by CEACAM1.

31 March 2020

1 reference

Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression

31 March 2020

1 reference

Bv8 regulates myeloid-cell-dependent tumour angiogenesis

31 March 2020

1 reference

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

31 March 2020

1 reference

The alliance of sphingosine-1-phosphate and its receptors in immunity

31 March 2020

1 reference

Sphingosine-1-phosphate signaling and its role in disease

31 March 2020

1 reference

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

31 March 2020

1 reference

Role for sphingosine kinase 1 in colon carcinogenesis.

31 March 2020

1 reference

Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells

31 March 2020

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S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.

31 March 2020

1 reference

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

31 March 2020

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Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells

31 March 2020

1 reference

The outs and the ins of sphingosine-1-phosphate in immunity

31 March 2020

1 reference

Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

31 March 2020

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S1PR1 is crucial for accumulation of regulatory T cells in tumors via STAT3.

31 March 2020

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Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells

31 March 2020

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Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells

31 March 2020

1 reference

Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells

31 March 2020

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Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival

31 March 2020

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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

31 March 2020

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Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.

31 March 2020

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Transcription factors as targets for cancer therapy

31 March 2020

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TLR4 knockout protects mice from radiation-induced thymic lymphoma by downregulation of IL6 and miR-21.

31 March 2020

1 reference

Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans

31 March 2020

1 reference

Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer

31 March 2020

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TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients

31 March 2020

1 reference

Effect of a novel anatomically shaped endotracheal tube on intubation-related injury

31 March 2020

1 reference

Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells.

31 March 2020

1 reference

Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3.

31 March 2020

1 reference

MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer

31 March 2020

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Systematic analysis of microRNA involved in resistance of the MCF-7 human breast cancer cell to doxorubicin

31 March 2020

1 reference

Computational analysis of microRNA profiles and their target genes suggests significant involvement in breast cancer antiestrogen resistance

31 March 2020

1 reference

MicroRNA-26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin-6-Stat3 pathway

31 March 2020

1 reference

Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression

31 March 2020

1 reference

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

31 March 2020

1 reference

Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.

31 March 2020

1 reference

Myeloid clusters are associated with a pro-metastatic environment and poor prognosis in smoking-related early stage non-small cell lung cancer

31 March 2020

1 reference

Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis

31 March 2020

1 reference

Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review

31 March 2020

1 reference

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

31 March 2020

1 reference

Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers

31 March 2020

1 reference

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

31 March 2020

1 reference

Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

31 March 2020

1 reference

31 March 2020

Stem cells: bad seeds

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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

31 March 2020

1 reference

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

31 March 2020

1 reference

Cancer stem cells: impact, heterogeneity, and uncertainty

31 March 2020

1 reference

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

31 March 2020

1 reference

Stem Cells and Cancer: Two Faces of Eve

31 March 2020

1 reference

STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells

31 March 2020

1 reference

Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells

31 March 2020

1 reference

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

31 March 2020

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The genes for leukemia inhibitory factor and interleukin-6 are expressed in mouse blastocysts prior to the onset of hemopoiesis

31 March 2020

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LIF receptor signaling modulates neural stem cell renewal.

31 March 2020

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Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.

31 March 2020

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Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth

31 March 2020

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JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells

31 March 2020

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Interleukin 6 mediated recruitment of mesenchymal stem cells to the hypoxic tumor milieu

31 March 2020

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Mesenchymal stem cells enhance lung cancer initiation through activation of IL-6/JAK2/STAT3 pathway

31 March 2020

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Differential regulation of myeloid leukemias by the bone marrow microenvironment

31 March 2020

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Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

31 March 2020

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Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal

31 March 2020

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Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells

31 March 2020

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Direct reprogramming of stem cell properties in colon cancer cells by CD44

31 March 2020

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Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.

31 March 2020

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Stat3 dimerization regulated by reversible acetylation of a single lysine residue

31 March 2020

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Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA.

31 March 2020

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Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activation

31 March 2020

1 reference

NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells

31 March 2020

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STAT3 acetylation-induced promoter methylation is associated with downregulation of the ARHI tumor-suppressor gene in ovarian cancer

31 March 2020

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Histone deacetylase 3 as a novel therapeutic target in multiple myeloma.

31 March 2020

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JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

31 March 2020

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LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease

31 March 2020

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Function of mitochondrial Stat3 in cellular respiration

31 March 2020

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Toward a new STATe: the role of STATs in mitochondrial function

31 March 2020

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Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

31 March 2020

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Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727

31 March 2020

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Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice

31 March 2020

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Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

31 March 2020

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Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway

31 March 2020

1 reference

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

31 March 2020

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TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo

31 March 2020

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Intestinal epithelial cells: regulators of barrier function and immune homeostasis

31 March 2020

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Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

31 March 2020

1 reference

STAT3 and its activators in intestinal defense and mucosal homeostasis.

31 March 2020

1 reference

Fine-tuning of GPCR activity by receptor-interacting proteins

31 March 2020

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Toll-like receptors and cancer

31 March 2020

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A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.

31 March 2020

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Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

31 March 2020

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Elevated serum IL-10 levels in diffuse large B-cell lymphoma: a mechanism of aberrant JAK2 activation

31 March 2020

1 reference

Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cells

31 March 2020

1 reference

MiR-135a targets JAK2 and inhibits gastric cancer cell proliferation

31 March 2020

1 reference

An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis

31 March 2020

1 reference

Serum interleukin 6 as a prognostic factor in patients with prostate cancer

31 March 2020

1 reference

12 December 2020

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

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12 December 2020

Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention

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12 December 2020

Adipokine regulation of colon cancer: adiponectin attenuates interleukin-6-induced colon carcinoma cell proliferation via STAT-3

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12 December 2020

Toll-like Receptors in Regulatory T Cells of Patients With Head and Neck Cancer

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12 December 2020

Identifiers

DOI

10.1038/NRC3818

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Dimensions Publication ID

1 September 2017

1014076105

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Fatcat ID

release_omqfobof6fh6ndquaqecosqhpm

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/omqfobof6fh6ndquaqecosqhpm

24 November 2022

mapped directly with Wikidata item

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