(Q38266759)

1 September 2017

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title

The RNA World: molecular cooperation at the origins of life (English)

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1 September 2017

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Paul G Higgs

1

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1 September 2017

Niles Lehman

series ordinal

2

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1 September 2017

publication date

11 November 2014

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1 September 2017

published in

Nature Reviews Genetics

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1 September 2017

volume

16

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1 September 2017

issue

1

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1 September 2017

page(s)

7-17

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The origin of the genetic code

1 September 2017

cites work

1 reference

Evolution of the genetic apparatus

21 January 2018

1 reference

Coenzymes as fossils of an earlier metabolic state

21 January 2018

2 references

21 January 2018

12 December 2020

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

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The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

21 January 2018

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The structural basis of ribosome activity in peptide bond synthesis

21 January 2018

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An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule

21 January 2018

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Forty years of in vitro evolution

21 January 2018

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An RNA that Multiplies Indefinitely with DNA-Dependent RNA Polymerase: Selection from a Random Copolymer

21 January 2018

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Kinetics of RNA replication: competition and selection among self-replicating RNA species

21 January 2018

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Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

21 January 2018

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Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

21 January 2018

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In vitro selection of RNA molecules that bind specific ligands

21 January 2018

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Ribozyme catalysis of metabolism in the RNA world

21 January 2018

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Gene regulation by riboswitches

21 January 2018

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Self-sustained replication of an RNA enzyme

21 January 2018

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RNA-catalyzed RNA polymerization: accurate and general RNA-templated primer extension

21 January 2018

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Selection of an improved RNA polymerase ribozyme with superior extension and fidelity

21 January 2018

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Closing the circle: replicating RNA with RNA

21 January 2018

1 reference

The "strong" RNA world hypothesis: fifty years old.

21 January 2018

1 reference

The case for an ancestral genetic system involving simple analogues of the nucleotides

21 January 2018

1 reference

The antiquity of RNA-based evolution

21 January 2018

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Asphalt, water, and the prebiotic synthesis of ribose, ribonucleosides, and RNA.

21 January 2018

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Borate minerals stabilize ribose

21 January 2018

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RNA: prebiotic product, or biotic invention?

21 January 2018

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Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

21 January 2018

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Evidence for reactive reduced phosphorus species in the early Archean ocean

21 January 2018

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Prebiotic synthesis of simple sugars by photoredox systems chemistry

21 January 2018

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Prebiotically plausible oligoribonucleotide ligation facilitated by chemoselective acetylation

21 January 2018

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Did template-directed nucleation precede molecular replication?

21 January 2018

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Eutectic Phase Polymerization of Activated Ribonucleotide Mixtures Yields Quasi-Equimolar Incorporation of Purine and Pyrimidine Nucleobases

21 January 2018

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Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization

21 January 2018

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Efficient self-assembly in water of long noncovalent polymers by nucleobase analogues.

21 January 2018

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Enhanced nonenzymatic ligation of homopurine miniduplexes: support for greater base stacking in a pre-RNA world

21 January 2018

1 reference

The origin of RNA and "my grandfather's axe".

21 January 2018

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Nonenzymatic template-directed synthesis on oligodeoxycytidylate sequences in hairpin oligonucleotides

21 January 2018

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RNA folding argues against a hot-start origin of life

21 January 2018

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Ligation activity of fragmented ribozymes in frozen solution: implications for the RNA world

21 January 2018

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Ribozyme-catalyzed transcription of an active ribozyme

21 January 2018

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In-ice evolution of RNA polymerase ribozyme activity

21 January 2018

1 reference

Origin of life: Cold-hearted RNA heats up life.

21 January 2018

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One-step, regioselective synthesis of up to 50-mers of RNA oligomers by montmorillonite catalysis

21 January 2018

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Detecting autocatalytic, self-sustaining sets in chemical reaction systems.

21 January 2018

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Autocatalytic sets in a partitioned biochemical network.

21 January 2018

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Self-assembly of a group I intron from inactive oligonucleotide fragments

21 January 2018

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Spontaneous network formation among cooperative RNA replicators

21 January 2018

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Recycling of informational units leads to selection of replicators in a prebiotic soup

21 January 2018

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Five rules for the evolution of cooperation

21 January 2018

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Spiral wave structure in pre-biotic evolution: Hypercycles stable against parasites

21 January 2018

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Bifurcations and phase transitions in spatially extended two-member hypercycles.

21 January 2018

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The Stochastic Evolution of Catalysts in Spatially Resolved Molecular Systems

21 January 2018

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Prebiotic replicase evolution in a surface-bound metabolic system: parasites as a source of adaptive evolution

21 January 2018

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The origin of life: chemical evolution of a metabolic system in a mineral honeycomb?

21 January 2018

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Marginally stable chemical systems as precursors of life.

21 January 2018

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In silico simulations reveal that replicators with limited dispersal evolve towards higher efficiency and fidelity

21 January 2018

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21 January 2018

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21 January 2018

Molecular quasi-species

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Evolutionary dynamics of RNA-like replicator systems: A bioinformatic approach to the origin of life

21 January 2018

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The role of complex formation and deleterious mutations for the stability of RNA-like replicator systems

21 January 2018

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The origin of life is a spatially localized stochastic transition

21 January 2018

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The importance of stochastic transitions for the origin of life

21 January 2018

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Evolution of complexity in RNA-like replicator systems

21 January 2018

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The evolution of strand preference in simulated RNA replicators with strand displacement: implications for the origin of transcription

21 January 2018

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Group selection of early replicators and the origin of life

21 January 2018

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Multilevel selection in models of prebiotic evolution II: a direct comparison of compartmentalization and spatial self-organization

21 January 2018

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The evolution of enzyme specificity in the metabolic replicator model of prebiotic evolution

21 January 2018

1 reference

Montmorillonite catalysis of 30-50 mer oligonucleotides: laboratory demonstration of potential steps in the origin of the RNA world

21 January 2018

1 reference

21 January 2018

1 reference

Synthetic protocell biology: from reproduction to computation

21 January 2018

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The emergence of competition between model protocells

21 January 2018

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Competition between model protocells driven by an encapsulated catalyst

21 January 2018

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RNA catalysis through compartmentalization.

21 January 2018

1 reference

Nonenzymatic template-directed RNA synthesis inside model protocells

21 January 2018

1 reference

Importance of parasite RNA species repression for prolonged translation-coupled RNA self-replication.

21 January 2018

1 reference

Chemical etiology of nucleic acid structure

21 January 2018

1 reference

Solution Structure, Mechanism of Replication, and Optimization of an Unnatural Base Pair

21 January 2018

1 reference

Amplification, mutation, and sequencing of a six-letter synthetic genetic system

21 January 2018

1 reference

Polymerase recognition of a Watson-Crick-like metal-mediated base pair: purine-2,6-dicarboxylate⋅copper(II)⋅ pyridine.

21 January 2018

1 reference

The structure of a TNA-TNA complex in solution: NMR study of the octamer duplex derived from alpha-(L)-threofuranosyl-(3'-2')-CGAATTCG.

21 January 2018

1 reference

Experimental evidence that GNA and TNA were not sequential polymers in the prebiotic evolution of RNA.

21 January 2018

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Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor.

21 January 2018

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Synthetic genetic polymers capable of heredity and evolution

21 January 2018

1 reference

DNA as a Versatile Chemical Component for Catalysis, Encoding, and Stereocontrol

21 January 2018

1 reference

The evolutionary transition from RNA to DNA in early cells.

21 January 2018

1 reference

DNA before proteins? Recent discoveries in nucleic acid catalysis strengthen the case

21 January 2018

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Prelife catalysts and replicators.

21 January 2018

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The basic reproductive ratio of life

21 January 2018

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From prelife to life: how chemical kinetics become evolutionary dynamics.

21 January 2018

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Origin of self-replicating biopolymers: autocatalytic feedback can jump-start the RNA world

21 January 2018

1 reference

Comparison of the roles of nucleotide synthesis, polymerization, and recombination in the origin of autocatalytic sets of RNAs

21 January 2018

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A simple template-dependent ligase ribozyme as the RNA replicase emerging first in the RNA world

21 January 2018

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Nucleotide synthetase ribozymes may have emerged first in the RNA world

21 January 2018

1 reference

Monte Carlo simulation of early molecular evolution in the RNA World

21 January 2018

1 reference

The origin and spread of a cooperative replicase in a prebiotic chemical system

21 January 2018

1 reference

The descent of polymerization

21 January 2018

1 reference

Enhancing the prebiotic relevance of a set of covalently self-assembling, autorecombining RNAs through in vitro selection

21 January 2018

1 reference

Quantification of monocarboxylic acids in the Murchison carbonaceous meteorite

21 January 2018

1 reference

A formal model of autocatalytic sets emerging in an RNA replicator system

21 January 2018

1 reference

Welcome Home, Systems Chemists!

21 January 2018

1 reference

A simpler origin for life

21 January 2018

2 references

31 March 2020

12 December 2020

On the Stabilization of Ribose by Silicate Minerals

1 reference

The limits of template-directed synthesis with nucleoside-5'-phosphoro(2-methyl)imidazolides

31 March 2020

1 reference

Efficient enzyme-free copying of all four nucleobases templated by immobilized RNA

31 March 2020

1 reference

Template-directed RNA polymerization: the taming of the milieu

31 March 2020

1 reference

Systems chemistry on ribozyme self-construction: evidence for anabolic autocatalysis in a recombination network

31 March 2020

1 reference

A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis

31 March 2020

1 reference

Evolution finds shelter in small spaces

31 March 2020

1 reference

Darwinian evolution in a translation-coupled RNA replication system within a cell-like compartment

31 March 2020

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Directed evolution of an RNA enzyme

31 March 2020

1 reference

12 December 2020

Before enzymes and templates: theory of surface metabolism

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12 December 2020

Biologically inspired synthetic enzymes made from DNA.

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12 December 2020

The first living systems: a bioenergetic perspective

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12 December 2020

The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle

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12 December 2020

Identifiers

DOI

10.1038/NRG3841

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Dimensions Publication ID

1 September 2017

1015195342

0 references

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