(Q38279829)

1 September 2017

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title

Homocysteine and DNA methylation: a review of animal and human literature (English)

1 reference

1 September 2017

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Pooja R Mandaviya

1

1 reference

PubMed ID

25456744

1 September 2017

Lisette Stolk

series ordinal

2

1 reference

PubMed ID

25456744

1 September 2017

Sandra G Heil

series ordinal

3

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1 September 2017

14 October 2014

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Molecular Genetics and Metabolism

1 September 2017

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1 September 2017

113

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1 September 2017

243-252

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1 September 2017

4

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1 September 2017

Homocysteine metabolism

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https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Homocysteine levels and the risk of osteoporotic fracture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Interrelations between plasma homocysteine and intracellular S-adenosylhomocysteine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Vitamin status and intake as primary determinants of homocysteinemia in an elderly population

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Vitamin B12 deficiency and hyperhomocysteinemia as correlates of cardiovascular risk factors in Indian subjects with coronary artery disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Homocysteine and folate concentrations in early pregnancy and the risk of adverse pregnancy outcomes: the Generation R Study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

The association between betaine and choline intakes and the plasma concentrations of homocysteine in women

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Hyperhomocysteinemia-mediated DNA hypomethylation and its potential epigenetic role in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE-/- mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Hyperhomocysteinemia induces cardiac injury by up-regulation of p53-dependent Noxa and Bax expression through the p53 DNA methylation in ApoE(-/-) mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Lack of effect of diet-induced hypomethylation on endothelium-dependent relaxation in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Differential effects of nutritional folic acid deficiency and moderate hyperhomocysteinemia on aortic plaque formation and genome-wide DNA methylation in vascular tissue from ApoE-/- mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Nutritional B vitamin deficiency disrupts lipid metabolism causing accumulation of proatherogenic lipoproteins in the aorta adventitia of ApoE null mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Mild neonatal hypoxia exacerbates the effects of vitamin-deficient diet on homocysteine metabolism in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Effects of parental folate deficiency on the folate content, global DNA methylation, and expressions of FRα, IGF-2 and IGF-1R in the postnatal rat liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Dietary folic acid intake differentially affects methionine metabolism markers and hippocampus morphology in aged rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Mice deficient in cystathionine beta synthase display altered homocysteine remethylation pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Cerebral vascular dysfunction in methionine synthase-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Epigenetic regulation of glucocorticoid receptor expression in aorta from mice with hyperhomocysteinemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Hepatic acyl-coenzyme a:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

The vegetarian lifestyle and DNA methylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Dietary intake, plasma homocysteine, and repetitive element DNA methylation in the Multi-Ethnic Study of Atherosclerosis (MESA).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Epigenetic alterations in folate transport genes in placental tissue from fetuses with neural tube defects and in leukocytes from subjects with hyperhomocysteinemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

LINE-1 DNA methylation is inversely correlated with cord plasma homocysteine in man: a preliminary study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Detection of altered global DNA methylation in coronary artery disease patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Ischemic heart disease and stroke in relation to blood DNA methylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Hypermethylation of estrogen receptor-alpha gene in atheromatosis patients and its correlation with homocysteine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Homocysteinylated protein levels in internal mammary artery (IMA) fragments and its genotype-dependence. S-homocysteine-induced methylation modifications in IMA and aortic fragments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

DNA methylation status is not impaired in treated cystathionine beta-synthase (CBS) deficient patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Methylation of estrogen receptor alpha and mutL homolog 1 in normal colonic mucosa: association with folate and vitamin B-12 status in subjects with and without colorectal neoplasia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

One-carbon metabolism and CpG island methylator phenotype status in incident colorectal cancer: a nested case-referent study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

The effect of modifiable potentials on hypermethylation status of retinoic acid receptor-beta2 and estrogen receptor-alpha genes in primary breast cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Impact of hyperhomocysteinemia on breast cancer initiation and progression: epigenetic perspective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Association between global leukocyte DNA methylation, renal function, carotid intima-media thickness and plasma homocysteine in patients with stage 2-4 chronic kidney disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Global DNA methylation not increased in chronic hemodialysis patients: a case-control study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

A metabolic link between S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in Alzheimer's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Global leukocyte DNA methylation is not altered in euthymic bipolar patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T and 1298A-->C mutations are associated with DNA hypomethylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Methylenetetrahydrofolate reductase 677C-->T polymorphism affects DNA methylation in response to controlled folate intake in young women

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

The MTHFR 677TT genotype and folate intake interact to lower global leukocyte DNA methylation in young Mexican American women

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Supranormal dietary folic acid supplementation: effects on methionine metabolism in weanling rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Effects of dietary supplementation of high-dose folic acid on biomarkers of methylating reaction in vitamin B(12)-deficient rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Effect of maternal and postweaning folic acid supplementation on global and gene-specific DNA methylation in the liver of the rat offspring

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspring

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Nutri-epigenetics ameliorates blood-brain barrier damage and neurodegeneration in hyperhomocysteinemia: role of folic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Short-term folate supplementation in physiological doses has no effect on ESR1 and MLH1 methylation in colonic mucosa of individuals with adenoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomas.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Folic acid effects on s-adenosylmethionine, s-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Reduction of the genomic damage level in haemodialysis patients by folic acid and vitamin B12 supplementation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Effect of 1 year B and D vitamin supplementation on LINE-1 repetitive element methylation in older subjects.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

No effect of folic acid supplementation on global DNA methylation in men and women with moderately elevated homocysteine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Impact of folic acid fortification on global DNA methylation and one-carbon biomarkers in the Women's Health Initiative Observational Study cohort

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

Leukocyte DNA as surrogate for the evaluation of imprinted Loci methylation in mammary tissue DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2014.10.006

10.1016/J.YMGME.2014.10.006

7 January 2021

Identifiers

DOI

1 reference

1 September 2017

1 reference

PubMed ID

25456744