(Q38286350)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496192%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

review article

1 reference

title

Gene-deleted live-attenuated Trypanosoma cruzi parasites as vaccines to protect against Chagas disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496192%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

0 references

0 references

1 reference

Cecilia Perez Brandan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496192%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

author name string

Fernando J Sánchez-Valdéz

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496192%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Arturo Ferreira

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496192%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Miguel Ángel Basombrío

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496192%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

publication date

11 December 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496192%20AND%20SRC:MED&resulttype=core&format=json

Expert Review of Vaccines

24 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496192%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496192%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496192%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

page(s)

681-697

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496192%20AND%20SRC:MED&resulttype=core&format=json

Pathogenesis of Chagas' disease

24 February 2020

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21 January 2018

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21 January 2018

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Chagas disease: a role for autoimmunity?

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Reactivation of Chagas disease with central nervous system involvement in HIV-infected patients in Argentina, 1992-2007.

21 January 2018

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Chagas' disease and AIDS

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Innovation for the 'bottom 100 million': eliminating neglected tropical diseases in the Americas

21 January 2018

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Texas and Mexico: sharing a legacy of poverty and neglected tropical diseases

21 January 2018

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The potential economic value of a Trypanosoma cruzi (Chagas disease) vaccine in Latin America

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Chagas disease: a Latin American health problem becoming a world health problem

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A handful of 'antipoverty' vaccines exist for neglected diseases, but the world's poorest billion people need more

21 January 2018

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Differential use of TLR2 and TLR9 in the regulation of immune responses during the infection with Trypanosoma cruzi

21 January 2018

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The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development

21 January 2018

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21 January 2018

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Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The genetic immunization with paraflagellar rod protein-2 fused to the HSP70 confers protection against late Trypanosoma cruzi infection

21 January 2018

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CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2.

21 January 2018

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Intranasal vaccinations with the trans-sialidase antigen plus CpG Adjuvant induce mucosal immunity protective against conjunctival Trypanosoma cruzi challenges.

21 January 2018

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Trans-sialidase recombinant protein mixed with CpG motif-containing oligodeoxynucleotide induces protective mucosal and systemic trypanosoma cruzi immunity involving CD8+ CTL and B cell-mediated cross-priming.

21 January 2018

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Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury in an experimental Trypanosoma cruzi infection model

21 January 2018

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Immunization with an engineered mutant trans-sialidase highly protects mice from experimental Trypanosoma cruzi infection: a vaccine candidate

21 January 2018

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Co-administration of a plasmid DNA encoding IL-15 improves long-term protection of a genetic vaccine against Trypanosoma cruzi

21 January 2018

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Heterologous plasmid DNA prime-recombinant human adenovirus 5 boost vaccination generates a stable pool of protective long-lived CD8(+) T effector memory cells specific for a human parasite, Trypanosoma cruzi

21 January 2018

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Oral vaccination with Salmonella enterica as a cruzipain-DNA delivery system confers protective immunity against Trypanosoma cruzi

21 January 2018

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Tc52 amino-terminal-domain DNA carried by attenuated Salmonella enterica serovar Typhimurium induces protection against a Trypanosoma cruzi lethal challenge

21 January 2018

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Preventive and therapeutic DNA vaccination partially protect dogs against an infectious challenge with Trypanosoma cruzi

21 January 2018

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Prophylactic efficacy of TcVac2 against Trypanosoma cruzi in mice

21 January 2018

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TcVac3 induced control of Trypanosoma cruzi infection and chronic myocarditis in mice

21 January 2018

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21 January 2018

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21 January 2018

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Function and regulation of memory CD4 T cells

21 January 2018

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Genetic manipulation of kinetoplastida

21 January 2018

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Stable DNA transfection of a wide range of trypanosomatids

21 January 2018

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Tests of cytoplasmic RNA interference (RNAi) and construction of a tetracycline-inducible T7 promoter system in Trypanosoma cruzi.

21 January 2018

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Live vaccination tactics: possible approaches for controlling visceral leishmaniasis

21 January 2018

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Genetic engineering of attenuated malaria parasites for vaccination

21 January 2018

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Biomarkers of safety and immune protection for genetically modified live attenuated leishmania vaccines against visceral leishmaniasis - discovery and implications

21 January 2018

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Generation of growth arrested Leishmania amastigotes: a tool to develop live attenuated vaccine candidates against visceral leishmaniasis

21 January 2018

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Genetically modified organisms and visceral leishmaniasis

21 January 2018

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Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

21 January 2018

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First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers

21 January 2018

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Centrin gene disruption impairs stage-specific basal body duplication and cell cycle progression in Leishmania

21 January 2018

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Induction of immunogenicity by live attenuated Leishmania donovani centrin deleted parasites in dogs

21 January 2018

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Live attenuated Leishmania donovani p27 gene knockout parasites are nonpathogenic and elicit long-term protective immunity in BALB/c mice

21 January 2018

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Deletion of mitochondrial associated ubiquitin fold modifier protein Ufm1 in Leishmania donovani results in loss of β-oxidation of fatty acids and blocks cell division in the amastigote stage

21 January 2018

1 reference

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Deletion of ubiquitin fold modifier protein Ufm1 processing peptidase Ufsp in L. donovani abolishes Ufm1 processing and alters pathogenesis

21 January 2018

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The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions

21 January 2018

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Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi

21 January 2018

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Oral exposure to Trypanosoma cruzi elicits a systemic CD8⁺ T cell response and protection against heterotopic challenge

21 January 2018

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Deletion of an immunodominant Trypanosoma cruzi surface glycoprotein disrupts flagellum-cell adhesion

21 January 2018

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Knockout of the gene encoding the kinetoplast-associated protein 3 (KAP3) in Trypanosoma cruzi: effect on kinetoplast organization, cell proliferation and differentiation.

21 January 2018

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The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements

21 January 2018

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The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology.

21 January 2018

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LYT1 protein is required for efficient in vitro infection by Trypanosoma cruzi.

21 January 2018

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Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge

21 January 2018

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Trypanosoma cruzi carrying a monoallelic deletion of the calreticulin (TcCRT) gene are susceptible to complement mediated killing and defective in their metacyclogenesis.

21 January 2018

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A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

21 January 2018

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Intracellular growth and metacyclogenesis defects in Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele

21 January 2018

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Functional complementation of glycoprotein 72 in a Trypanosoma cruzi glycoprotein 72 null mutant.

21 January 2018

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Targeted deletion of the gp72 gene decreases the infectivity of Trypanosoma cruzi for mice and insect vectors.

21 January 2018

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Trypanosoma cruzi: attenuation of virulence and protective immunogenicity after monoallelic disruption of the cub gene.

21 January 2018

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Impairment of infectivity and immunoprotective effect of a LYT1 null mutant of Trypanosoma cruzi

21 January 2018

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The Trypanosoma cruzi proteome.

21 January 2018

1 reference

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Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi

21 January 2018

1 reference

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In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Double targeted gene replacement for creating null mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

CD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Trypanosoma cruzi calreticulin is a lectin that binds monoglucosylated oligosaccharides but not protein moieties of glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

The classical activation pathway of the human complement system is specifically inhibited by calreticulin from Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Role of calreticulin from parasites in its interaction with vertebrate hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Trypanosoma cruzi calreticulin: a novel virulence factor that binds complement C1 on the parasite surface and promotes infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Biological behavior of different Trypanosoma cruzi isolates circulating in an endemic area for Chagas disease in the Gran Chaco region of Argentina.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

A monoallelic deletion of the TcCRT gene increases the attenuation of a cultured Trypanosoma cruzi strain, protecting against an in vivo virulent challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Mitochondrial localization of the mevalonate pathway enzyme 3-Hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Oral transmission of Chagas disease by consumption of açaí palm fruit, Brazil

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Distinctive histopathology and modulation of cytokine production during oral and intraperitoneal Trypanosoma cruzi Y strain infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

T cell vaccines for microbial infections

21 January 2018

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https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Differential immunogenicity of various heterologous prime-boost vaccine regimens using DNA and viral vectors in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Plasticity in chromosome number and testing of essential genes in Leishmania by targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Ploidy changes associated with disruption of two adjacent genes on Leishmania major chromosome 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Modeling household transmission of American trypanosomiasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Human Trypanosoma cruzi infection and seropositivity in dogs, Mexico

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Domestic dogs and cats as sources of Trypanosoma cruzi infection in rural northwestern Argentina

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Current Status of Veterinary Vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Development of a recombinant Leishmania major strain sensitive to ganciclovir and 5-fluorocytosine for use as a live vaccine challenge in clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

A dual drug sensitive L. major induces protection without lesion in C57BL/6 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Plasmid vectors and molecular building blocks for the development of genetic manipulation tools for Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Cloning and expression of transgenes using linear vectors in Trypanosoma cruzi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Development and applications of CRISPR-Cas9 for genome engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

Immunisation with a major Trypanosoma cruzi antigen promotes pro-inflammatory cytokines, nitric oxide production and increases TLR2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14760584.2015.989989

10.1586/14760584.2015.989989

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25496192%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference