(Q38287819)

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Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis.

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25 February 2020

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Europe PubMed Central

Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis (English)

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25504962%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

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25 February 2020

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Eva Thijssen

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25 February 2020

Peter M van der Kraan

3

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25 February 2020

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11 December 2014

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25 February 2020

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25 February 2020

54

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25 February 2020

4

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25 February 2020

588-600

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25 February 2020

Osteoarthritis: epidemiology

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Developments in the scientific understanding of osteoarthritis

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Obesity and Knee Osteoarthritis

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Obesity, overweight and patterns of osteoarthritis

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Adipose tissue as an endocrine organ

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Dyslipidemia in obesity: mechanisms and potential targets

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Body mass index affects knee joint mechanics during gait differently with and without moderate knee osteoarthritis

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

The effects of high magnitude cyclic tensile load on cartilage matrix metabolism in cultured chondrocytes.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Increased stromelysin-1 (MMP-3), proteoglycan degradation (3B3- and 7D4) and collagen damage in cyclically load-injured articular cartilage.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Chronic in vivo load alteration induces degenerative changes in the rat tibiofemoral joint

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Regulation of subchondral bone osteoblast metabolism by cyclic compression

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

New insights into the mechanism of low high-density lipoprotein cholesterol in obesity

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

An increase in lipoprotein oxidation and endogenous lipid peroxides in serum of obese women.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Total cholesterol and triglycerides are associated with the development of new bone marrow lesions in asymptomatic middle-aged women - a prospective cohort study

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Perturbations in the HDL metabolic pathway predispose to the development of osteoarthritis in mice following long-term exposure to western-type diet

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Bone marrow abnormalities on magnetic resonance imaging are associated with type II collagen degradation in knee osteoarthritis: a three-month longitudinal study.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Increase in bone marrow lesions associated with cartilage loss: A longitudinal magnetic resonance imaging study of knee osteoarthritis

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Bone marrow edema and its relation to progression of knee osteoarthritis.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Assessment of paraoxonase activities in patients with knee osteoarthritis

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

An endothelial receptor for oxidized low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Possible involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system in pathogenesis and progression of human osteoarthritis.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

In vivo regulation of plasma free fatty acids in insulin resistance

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Obesity is associated with macrophage accumulation in adipose tissue

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Immune regulation in obesity-associated adipose inflammation

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

The infrapatellar fat pad in knee osteoarthritis: an important source of interleukin-6 and its soluble receptor

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Cytokine production in the infrapatellar fat pad: another source of cytokines in knee synovial fluids.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Roles of degree of fat deposition and its localization on VEGF expression in adipocytes

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Mice lacking link protein develop dwarfism and craniofacial abnormalities.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockade

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Characterization of synovial angiogenesis in osteoarthritis patients and its modulation by chondroitin sulfate

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

The potential role of vascular endothelial growth factor (VEGF) in cartilage: how the angiogenic factor could be involved in the pathogenesis of osteoarthritis?

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Initial responses of articular tissues in a murine high-fat diet-induced osteoarthritis model: pivotal role of the IPFP as a cytokine fountain

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Secreted proteins from adipose tissue and skeletal muscle - adipokines, myokines and adipose/muscle cross-talk

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Evidence for a key role of leptin in osteoarthritis

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Serum Resistin (FIZZ3) Protein Is Increased in Obese Humans

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Plasma visfatin concentrations and fat depot-specific mRNA expression in humans

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Chemerin is a novel adipokine associated with obesity and metabolic syndrome

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Serum chemerin levels vary with time of day and are modified by obesity and tumor necrosis factor-{alpha}.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Leptin induces IL-6 expression through OBRl receptor signaling pathway in human synovial fibroblasts

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Leptin plays a catabolic role on articular cartilage

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Serum resistin level is associated with radiographic changes in hand osteoarthritis: cross-sectional study.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Increased serum adiponectin levels in female patients with erosive compared with non-erosive osteoarthritis.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Visfatin/pre-B-cell colony-enhancing factor (PBEF), a proinflammatory and cell motility-changing factor in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Chemerin induces CCL2 and TLR4 in synovial fibroblasts of patients with rheumatoid arthritis and osteoarthritis

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin(21-157).

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

The biology of leptin: a review

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Adiponectin--a key adipokine in the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Plasma Adiponectin in Patients with Active, Early, and Chronic Rheumatoid Arthritis Who Are Steroid- and Disease-Modifying Antirheumatic Drug-Naive Compared with Patients with Osteoarthritis and Controls

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex.

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Adiponectin as a biomarker of the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Inflammation and angiogenesis in osteoarthritis

1 reference

https://api.crossref.org/works/10.1093%2FRHEUMATOLOGY%2FKEU464

21 January 2018

Identifiers

10.1093/RHEUMATOLOGY/KEU464

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25504962%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25504962%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

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