(Q38296498)

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Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein

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Europe PubMed Central

PubMed publication ID

1 September 2017

Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein (English)

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Europe PubMed Central

PubMed publication ID

1 September 2017

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dopaminergic neuron

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based on heuristic

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Wai Haung Yu

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author name string

Yasuji Matsuoka

2

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Europe PubMed Central

PubMed publication ID

1 September 2017

István Sziráki

3

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Europe PubMed Central

PubMed publication ID

1 September 2017

Audrey Hashim

4

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Europe PubMed Central

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1 September 2017

John Lafrancois

5

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Europe PubMed Central

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1 September 2017

Henry Sershen

6

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Europe PubMed Central

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1 September 2017

Karen E Duff

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1 September 2017

publication date

13 November 2007

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Europe PubMed Central

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1 September 2017

Neurochemical Research

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Europe PubMed Central

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1 September 2017

33

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Europe PubMed Central

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1 September 2017

5

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Europe PubMed Central

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1 September 2017

902-911

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Europe PubMed Central

PubMed publication ID

1 September 2017

https://scigraph.springernature.com/pub.10.1007/s11064-007-9533-4

0 references

Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9533-4

21 January 2018

Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9533-4

21 January 2018

Oxidative stress and the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9533-4

21 January 2018

The parkinsonian toxin MPTP: action and mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Olfactory loss may be a first sign of idiopathic Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of Parkinson's disease-associated alpha-synucleinA53T by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein expression in substantia nigra and cortex in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) binding sites in C57BL/6 mouse brain: mutual effects of monoamine oxidase inhibitors and sigma ligands on MPTP and sigma binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on age-related changes in dopamine turnover and transporter function in the mouse striatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired olfactory function in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking alpha-synuclein are resistant to mitochondrial toxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal alpha-synuclein solubility, aggregation and nitration in the frontal cortex in Pick's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Olfactory dysfunction in familial parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Odor identification deficits in diffuse lewy body disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative modifications of alpha-synuclein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-like compounds on mitochondrial respiration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free 3-nitrotyrosine causes striatal neurodegeneration in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the major transport pathway for the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Olfactory impairment in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endostatin induces autophagic cell death in EAhy926 human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical pathophysiology of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces norepinephrine concentrations in the olfactory bulbs of male mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine terminal loss and onset of motor symptoms in MPTP-treated monkeys: a positron emission tomography study with 11C-CFT.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal pathology associated with alpha-synuclein accumulation in transgenic models using an eGFP fusion protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Snaring the function of alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anterior olfactory nucleus in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autosomal dominant Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methamphetamine protects against MPTP neurotoxicity in C57BL mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of major olfactory dysfunction in MPTP-induced parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Understanding cell death in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Olfaction in neurodegenerative disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein in Lewy bodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lewy body diseases and multiple system atrophy as alpha-synucleinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathology in mice expressing human alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New genetic insights into Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Environmental factors in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of intranasal infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) upon catecholamine concentrations within olfactory bulbs and corpus striatum of male mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synucleins in synaptic plasticity and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17999181

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11064-007-9533-4

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

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release_a7qivmb5lbaldhgtvchlqjttpm

1 reference

https://api.fatcat.wiki/v0/release/a7qivmb5lbaldhgtvchlqjttpm

24 November 2022

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mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

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