(Q38307044)

English

The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation

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scholarly article

1 reference

Europe PubMed Central

2 September 2017

The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation (English)

1 reference

Europe PubMed Central

2 September 2017

author name string

Bruno Marchand

1

1 reference

Europe PubMed Central

2 September 2017

Egor P Tchesnokov

2

1 reference

Europe PubMed Central

2 September 2017

Matthias Götte

3

1 reference

Europe PubMed Central

2 September 2017

language of work or name

0 references

publication date

30 November 2006

1 reference

Europe PubMed Central

2 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

2 September 2017

282

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Europe PubMed Central

2 September 2017

5

1 reference

Europe PubMed Central

2 September 2017

3337-3346

1 reference

Europe PubMed Central

2 September 2017

Emerging anti-HIV drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Antiviral drugs in current clinical use.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Foscarnet used in salvage therapy of HIV-1 patients harbouring multiple nucleotide excision mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Relationship between 3′-Azido-3′-Deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-Resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Characterisation of foscarnet-resistant strains of human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Alkylglycerol prodrugs of phosphonoformate are potent in vitro inhibitors of nucleoside-resistant human immunodeficiency virus type 1 and select for resistance mutations that suppress zidovudine resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Inhibition of the initiation of HIV-1 reverse transcription by 3'-azido-3'-deoxythymidine. Comparison with elongation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Kinetic mechanism of DNA polymerase I(Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

The structural mechanism of translocation and helicase activity in T7 RNA polymerase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Trapping HIV-1 reverse transcriptase before and after translocation on DNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Impact of the translocational equilibrium of HIV-1 reverse transcriptase on the efficiency of mismatch extensions and the excision of mispaired nucleotides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

A model for the mechanism of polymerase translocation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Effects of nucleotides and nucleotide analogue inhibitors of HIV-1 reverse transcriptase in a ratchet model of polymerase translocation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

NTP concentration effects on initial transcription by T7 RNAP indicate that translocation occurs through passive sliding and reveal that divergent promoters have distinct NTP concentration requirements for productive initiation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Direct observation of base-pair stepping by RNA polymerase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

NTP-driven translocation by human RNA polymerase II.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Impaired fitness of foscarnet-resistant strains of human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

A Ratchet Mechanism of Transcription Elongation and Its Control

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Selective Excision of Chain-terminating Nucleotides by HIV-1 Reverse Transcriptase with Phosphonoformate as Substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607710200

21 January 2018

Identifiers

10.1074/JBC.M607710200

1 reference

Europe PubMed Central

2 September 2017

1 reference

Europe PubMed Central

2 September 2017

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